Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss Therapy
Objective:Adiposity is associated with increased oxidative stress, leading to changed fat-soluble vitamin concentrations. The aim of this study was to determine whether weight loss alters fat-soluble vitamin status and whether these alterations are associated with dietary intake, anthropometric para...
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2021-06-01
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| Series: | JCRPE |
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http://www.jcrpe.org/archives/archive-detail/article-preview/associations-between-antioxidant-vitamin-status-di/42130
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| author | Joanna Gajewska Jadwiga Ambroszkiewicz Katarzyna Szamotulska Witold Klemarczyk Halina Weker Magdalena Chełchowska |
| author_facet | Joanna Gajewska Jadwiga Ambroszkiewicz Katarzyna Szamotulska Witold Klemarczyk Halina Weker Magdalena Chełchowska |
| author_sort | Joanna Gajewska |
| collection | DOAJ |
| description | Objective:Adiposity is associated with increased oxidative stress, leading to changed fat-soluble vitamin concentrations. The aim of this study was to determine whether weight loss alters fat-soluble vitamin status and whether these alterations are associated with dietary intake, anthropometric parameters and adipokines in obese children.Methods:Vitamin A and E concentrations were measured using high-pressure liquid chromatography in 60 obese children before and after weight loss therapy. Retinol-binding protein 4 (RBP4), leptin, soluble leptin receptor (sOB-R), and high molecular weight adiponectin concentrations were determined by immunoenzymatic assays.Results:The intake of vitamin E was lower in obese children with weight loss after therapy (p=0.038). In this group, an increase was found in the vitamin A/lipids (p=0.022) and the vitamin E/lipids (p=0.008) ratios but due to the reduction in triglyceride levels. In the obese group, changes in vitamin E level were positively correlated with changes in dietary vitamin E (p=0.017) and the leptin/sOB-R ratio (p=0.046). Changes in vitamin A level were positively correlated with changes in dietary vitamin A (p=0.001) and RBP4 concentration (p=0.023). Associations between changes in RBP4 level with the changes in body mass index (BMI) (p=0.011) and total cholesterol concentration (p=0.023) but not with changes in vitamin A concentration were found in the obese after therapy.Conclusion:An increased risk of vitamin E deficiency may occur in children losing weight during lifestyle intervention. Changes in BMI value may influence changes in RBP4 concentrations and consequently the vitamin A status in obese children after therapy. |
| first_indexed | 2024-04-10T10:19:19Z |
| format | Article |
| id | doaj.art-be57b40478b2476091619c682b45d6b4 |
| institution | Directory Open Access Journal |
| issn | 1308-5727 1308-5735 |
| language | English |
| last_indexed | 2024-04-10T10:19:19Z |
| publishDate | 2021-06-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | JCRPE |
| spelling | doaj.art-be57b40478b2476091619c682b45d6b42023-02-15T16:21:44ZengGalenos YayincilikJCRPE1308-57271308-57352021-06-0113218719710.4274/jcrpe.galenos.2020.2020.020713049054Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss TherapyJoanna Gajewska0Jadwiga Ambroszkiewicz1Katarzyna Szamotulska2Witold Klemarczyk3Halina Weker4Magdalena Chełchowska5 Institute of Mother and Child, Department of Screening and Metabolic Diagnostics, Warsaw, Poland Institute of Mother and Child, Department of Screening and Metabolic Diagnostics, Warsaw, Poland Institute of Mother and Child, Department of Epidemiology and Biostatistics, Warsaw, Poland Institute of Mother and Child, Department of Nutrition, Warsaw, Poland Institute of Mother and Child, Department of Nutrition, Warsaw, Poland Institute of Mother and Child, Department of Screening and Metabolic Diagnostics, Warsaw, Poland Objective:Adiposity is associated with increased oxidative stress, leading to changed fat-soluble vitamin concentrations. The aim of this study was to determine whether weight loss alters fat-soluble vitamin status and whether these alterations are associated with dietary intake, anthropometric parameters and adipokines in obese children.Methods:Vitamin A and E concentrations were measured using high-pressure liquid chromatography in 60 obese children before and after weight loss therapy. Retinol-binding protein 4 (RBP4), leptin, soluble leptin receptor (sOB-R), and high molecular weight adiponectin concentrations were determined by immunoenzymatic assays.Results:The intake of vitamin E was lower in obese children with weight loss after therapy (p=0.038). In this group, an increase was found in the vitamin A/lipids (p=0.022) and the vitamin E/lipids (p=0.008) ratios but due to the reduction in triglyceride levels. In the obese group, changes in vitamin E level were positively correlated with changes in dietary vitamin E (p=0.017) and the leptin/sOB-R ratio (p=0.046). Changes in vitamin A level were positively correlated with changes in dietary vitamin A (p=0.001) and RBP4 concentration (p=0.023). Associations between changes in RBP4 level with the changes in body mass index (BMI) (p=0.011) and total cholesterol concentration (p=0.023) but not with changes in vitamin A concentration were found in the obese after therapy.Conclusion:An increased risk of vitamin E deficiency may occur in children losing weight during lifestyle intervention. Changes in BMI value may influence changes in RBP4 concentrations and consequently the vitamin A status in obese children after therapy. http://www.jcrpe.org/archives/archive-detail/article-preview/associations-between-antioxidant-vitamin-status-di/42130 vitamin avitamin eretinol-binding protein 4prepubertal periodweight loss therapy |
| spellingShingle | Joanna Gajewska Jadwiga Ambroszkiewicz Katarzyna Szamotulska Witold Klemarczyk Halina Weker Magdalena Chełchowska Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss Therapy JCRPE vitamin a vitamin e retinol-binding protein 4 prepubertal period weight loss therapy |
| title | Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss Therapy |
| title_full | Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss Therapy |
| title_fullStr | Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss Therapy |
| title_full_unstemmed | Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss Therapy |
| title_short | Associations Between Antioxidant Vitamin Status, Dietary Intake, and Retinol-binding Protein 4 Levels in Prepubertal Obese Children After 3-month Weight Loss Therapy |
| title_sort | associations between antioxidant vitamin status dietary intake and retinol binding protein 4 levels in prepubertal obese children after 3 month weight loss therapy |
| topic | vitamin a vitamin e retinol-binding protein 4 prepubertal period weight loss therapy |
| url |
http://www.jcrpe.org/archives/archive-detail/article-preview/associations-between-antioxidant-vitamin-status-di/42130
|
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