Tumor Necrosis Factor: What Is in a Name?
Tumor Necrosis Factor was one of the first cytokines described in the literature as a soluble mediator of cytotoxicity to tumors. Over the years, more extensive research that tried to employ Tumor Necrosis Factor in cancer treatments showed nevertheless that it mainly functioned as a proinflammatory...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/21/5270 |
| _version_ | 1797468877726154752 |
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| author | Xinming Wang Chunlan Yang Heinrich Körner Chaoliang Ge |
| author_facet | Xinming Wang Chunlan Yang Heinrich Körner Chaoliang Ge |
| author_sort | Xinming Wang |
| collection | DOAJ |
| description | Tumor Necrosis Factor was one of the first cytokines described in the literature as a soluble mediator of cytotoxicity to tumors. Over the years, more extensive research that tried to employ Tumor Necrosis Factor in cancer treatments showed nevertheless that it mainly functioned as a proinflammatory cytokine. However, this did not stop the search for the holy grail of cancer research: A cytokine that could act as a one-stop treatment for solid tumors and lymphomas. This review will summarize the long experimental history of Tumor Necrosis Factor that caused the initial observations of a tumor necrotizing cytokine that could serve as a potential cancer treatment and discuss the current state of research into this side of the activities of Tumor Necrosis Factor. |
| first_indexed | 2024-03-09T19:13:36Z |
| format | Article |
| id | doaj.art-be58b0d6d65849878e3f5594c57a4d44 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T19:13:36Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-be58b0d6d65849878e3f5594c57a4d442023-11-24T04:01:44ZengMDPI AGCancers2072-66942022-10-011421527010.3390/cancers14215270Tumor Necrosis Factor: What Is in a Name?Xinming Wang0Chunlan Yang1Heinrich Körner2Chaoliang Ge3Department of Pharmacy, First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaDepartment of Pharmacy, First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaMenzies Institute for Medical Research, Liverpool Street, Hobart, TAS 7000, AustraliaDepartment of Pharmacy, First Affiliated Hospital of Anhui Medical University, Hefei 230022, ChinaTumor Necrosis Factor was one of the first cytokines described in the literature as a soluble mediator of cytotoxicity to tumors. Over the years, more extensive research that tried to employ Tumor Necrosis Factor in cancer treatments showed nevertheless that it mainly functioned as a proinflammatory cytokine. However, this did not stop the search for the holy grail of cancer research: A cytokine that could act as a one-stop treatment for solid tumors and lymphomas. This review will summarize the long experimental history of Tumor Necrosis Factor that caused the initial observations of a tumor necrotizing cytokine that could serve as a potential cancer treatment and discuss the current state of research into this side of the activities of Tumor Necrosis Factor.https://www.mdpi.com/2072-6694/14/21/5270TNFinflammationcancer |
| spellingShingle | Xinming Wang Chunlan Yang Heinrich Körner Chaoliang Ge Tumor Necrosis Factor: What Is in a Name? Cancers TNF inflammation cancer |
| title | Tumor Necrosis Factor: What Is in a Name? |
| title_full | Tumor Necrosis Factor: What Is in a Name? |
| title_fullStr | Tumor Necrosis Factor: What Is in a Name? |
| title_full_unstemmed | Tumor Necrosis Factor: What Is in a Name? |
| title_short | Tumor Necrosis Factor: What Is in a Name? |
| title_sort | tumor necrosis factor what is in a name |
| topic | TNF inflammation cancer |
| url | https://www.mdpi.com/2072-6694/14/21/5270 |
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