Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice
The impact of positive environment stimulations (eustress) on cancer biology remains poorly understood. Here the authors show that exposure to an environment enrichment stimulates anti-tumor immunity and reduces tumor growth in preclinical models of liver cancer.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25967-9 |
| _version_ | 1818845607593246720 |
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| author | Chaobao Liu Yang Yang Cheng Chen Ling Li Jingquan Li Xiaonan Wang Qiao Chu Lin Qiu Qian Ba Xiaoguang Li Hui Wang |
| author_facet | Chaobao Liu Yang Yang Cheng Chen Ling Li Jingquan Li Xiaonan Wang Qiao Chu Lin Qiu Qian Ba Xiaoguang Li Hui Wang |
| author_sort | Chaobao Liu |
| collection | DOAJ |
| description | The impact of positive environment stimulations (eustress) on cancer biology remains poorly understood. Here the authors show that exposure to an environment enrichment stimulates anti-tumor immunity and reduces tumor growth in preclinical models of liver cancer. |
| first_indexed | 2024-12-19T05:32:21Z |
| format | Article |
| id | doaj.art-be5a062266a54b60a3d9d8b31385a8f8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:32:21Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-be5a062266a54b60a3d9d8b31385a8f82022-12-21T20:34:13ZengNature PortfolioNature Communications2041-17232021-09-0112111510.1038/s41467-021-25967-9Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in miceChaobao Liu0Yang Yang1Cheng Chen2Ling Li3Jingquan Li4Xiaonan Wang5Qiao Chu6Lin Qiu7Qian Ba8Xiaoguang Li9Hui Wang10State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineCAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineThe impact of positive environment stimulations (eustress) on cancer biology remains poorly understood. Here the authors show that exposure to an environment enrichment stimulates anti-tumor immunity and reduces tumor growth in preclinical models of liver cancer.https://doi.org/10.1038/s41467-021-25967-9 |
| spellingShingle | Chaobao Liu Yang Yang Cheng Chen Ling Li Jingquan Li Xiaonan Wang Qiao Chu Lin Qiu Qian Ba Xiaoguang Li Hui Wang Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice Nature Communications |
| title | Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice |
| title_full | Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice |
| title_fullStr | Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice |
| title_full_unstemmed | Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice |
| title_short | Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice |
| title_sort | environmental eustress modulates β ars ccl2 axis to induce anti tumor immunity and sensitize immunotherapy against liver cancer in mice |
| url | https://doi.org/10.1038/s41467-021-25967-9 |
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