Brachytherapy in the Treatment of Soft-Tissue Sarcomas of the Extremities—A Current Concept and Systematic Review of the Literature
Introduction: Evidence on the use of brachytherapy in soft-tissue sarcoma (STS) is sparse. Therapy regimens are determined more by local interdisciplinary tumor conferences than by standardized protocols. Patient-specific factors complicate the standardized application of therapy protocols. The indi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/4/1133 |
| _version_ | 1797621879618404352 |
|---|---|
| author | Johannes Neugebauer Philipp Blum Alexander Keiler Markus Süß Markus Neubauer Lukas Moser Dietmar Dammerer |
| author_facet | Johannes Neugebauer Philipp Blum Alexander Keiler Markus Süß Markus Neubauer Lukas Moser Dietmar Dammerer |
| author_sort | Johannes Neugebauer |
| collection | DOAJ |
| description | Introduction: Evidence on the use of brachytherapy in soft-tissue sarcoma (STS) is sparse. Therapy regimens are determined more by local interdisciplinary tumor conferences than by standardized protocols. Patient-specific factors complicate the standardized application of therapy protocols. The individuality of the treatment makes it difficult to compare results. Materials and Methods: A comprehensive literature search was conducted, whereby the literature from a period of almost 44 years (1977–2021) was graded and included in this systematic review. For this purpose, PubMed was used as the primary database. Search string included “soft-tissue sarcoma”, “brachytherapy”, and “extremity.” Four independent researchers reviewed the literature. Only full-text articles written in English or German were included. Results: Of the 175 identified studies, 70 were eligible for analysis based on the inclusion and exclusion criteria. The key points to compare were local complications, recurrence rate and correlation with margins of resection, and the use of brachytherapy regarding tumor grading. Conclusion: Brachytherapy represents an important subset of radiotherapy techniques used in STSs, whose indications and applications are constantly evolving, and for which a local control rate of 50% to 96% has been reported as monotherapy, depending on risk factors. However, the best benefit is seen in the combination of further resection and brachytherapy, and most authors at many other centers agree with this treatment strategy. |
| first_indexed | 2024-03-11T09:03:21Z |
| format | Article |
| id | doaj.art-be5c83023e26485da0e6e3b145fbc8a7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:03:21Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-be5c83023e26485da0e6e3b145fbc8a72023-11-16T19:36:39ZengMDPI AGCancers2072-66942023-02-01154113310.3390/cancers15041133Brachytherapy in the Treatment of Soft-Tissue Sarcomas of the Extremities—A Current Concept and Systematic Review of the LiteratureJohannes Neugebauer0Philipp Blum1Alexander Keiler2Markus Süß3Markus Neubauer4Lukas Moser5Dietmar Dammerer6Department of Orthopaedics and Traumatology, Krems University Hospital, 3500 Krems, AustriaDepartment of Trauma Surgery, BG Trauma Center Murnau, 82418 Murnau, GermanyDepartment of Orthopaedics and Traumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Orthopaedics and Traumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Orthopaedics and Traumatology, Krems University Hospital, 3500 Krems, AustriaDepartment of Orthopaedics and Traumatology, Krems University Hospital, 3500 Krems, AustriaDepartment of Orthopaedics and Traumatology, Krems University Hospital, 3500 Krems, AustriaIntroduction: Evidence on the use of brachytherapy in soft-tissue sarcoma (STS) is sparse. Therapy regimens are determined more by local interdisciplinary tumor conferences than by standardized protocols. Patient-specific factors complicate the standardized application of therapy protocols. The individuality of the treatment makes it difficult to compare results. Materials and Methods: A comprehensive literature search was conducted, whereby the literature from a period of almost 44 years (1977–2021) was graded and included in this systematic review. For this purpose, PubMed was used as the primary database. Search string included “soft-tissue sarcoma”, “brachytherapy”, and “extremity.” Four independent researchers reviewed the literature. Only full-text articles written in English or German were included. Results: Of the 175 identified studies, 70 were eligible for analysis based on the inclusion and exclusion criteria. The key points to compare were local complications, recurrence rate and correlation with margins of resection, and the use of brachytherapy regarding tumor grading. Conclusion: Brachytherapy represents an important subset of radiotherapy techniques used in STSs, whose indications and applications are constantly evolving, and for which a local control rate of 50% to 96% has been reported as monotherapy, depending on risk factors. However, the best benefit is seen in the combination of further resection and brachytherapy, and most authors at many other centers agree with this treatment strategy.https://www.mdpi.com/2072-6694/15/4/1133high-dose brachytherapyhigh-grade soft-tissue sarcomaintraoperative brachytherapysoft-tissue sarcoma of the extremities |
| spellingShingle | Johannes Neugebauer Philipp Blum Alexander Keiler Markus Süß Markus Neubauer Lukas Moser Dietmar Dammerer Brachytherapy in the Treatment of Soft-Tissue Sarcomas of the Extremities—A Current Concept and Systematic Review of the Literature Cancers high-dose brachytherapy high-grade soft-tissue sarcoma intraoperative brachytherapy soft-tissue sarcoma of the extremities |
| title | Brachytherapy in the Treatment of Soft-Tissue Sarcomas of the Extremities—A Current Concept and Systematic Review of the Literature |
| title_full | Brachytherapy in the Treatment of Soft-Tissue Sarcomas of the Extremities—A Current Concept and Systematic Review of the Literature |
| title_fullStr | Brachytherapy in the Treatment of Soft-Tissue Sarcomas of the Extremities—A Current Concept and Systematic Review of the Literature |
| title_full_unstemmed | Brachytherapy in the Treatment of Soft-Tissue Sarcomas of the Extremities—A Current Concept and Systematic Review of the Literature |
| title_short | Brachytherapy in the Treatment of Soft-Tissue Sarcomas of the Extremities—A Current Concept and Systematic Review of the Literature |
| title_sort | brachytherapy in the treatment of soft tissue sarcomas of the extremities a current concept and systematic review of the literature |
| topic | high-dose brachytherapy high-grade soft-tissue sarcoma intraoperative brachytherapy soft-tissue sarcoma of the extremities |
| url | https://www.mdpi.com/2072-6694/15/4/1133 |
| work_keys_str_mv | AT johannesneugebauer brachytherapyinthetreatmentofsofttissuesarcomasoftheextremitiesacurrentconceptandsystematicreviewoftheliterature AT philippblum brachytherapyinthetreatmentofsofttissuesarcomasoftheextremitiesacurrentconceptandsystematicreviewoftheliterature AT alexanderkeiler brachytherapyinthetreatmentofsofttissuesarcomasoftheextremitiesacurrentconceptandsystematicreviewoftheliterature AT markussuß brachytherapyinthetreatmentofsofttissuesarcomasoftheextremitiesacurrentconceptandsystematicreviewoftheliterature AT markusneubauer brachytherapyinthetreatmentofsofttissuesarcomasoftheextremitiesacurrentconceptandsystematicreviewoftheliterature AT lukasmoser brachytherapyinthetreatmentofsofttissuesarcomasoftheextremitiesacurrentconceptandsystematicreviewoftheliterature AT dietmardammerer brachytherapyinthetreatmentofsofttissuesarcomasoftheextremitiesacurrentconceptandsystematicreviewoftheliterature |