The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study
Abstract Background: The prevalence of vitamin D deficiency and male infertility is high in Iran. Objective: The present research aimed to examine the association between serum vitamin D [25(OH)D], parameters of semen including semen volume, sperm count, motility and morphology, and reproductive hor...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2022-04-01
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| Series: | International Journal of Reproductive BioMedicine |
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| Online Access: | https://doi.org/10.18502/ijrm.v20i4.10905 |
| _version_ | 1811342086078726144 |
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| author | Leila Maghsoumi-Norouzabad Maryam Labibzadeh Ahmad Zare Javid Seyed Ahmad Hosseini Gholam Abbas Kaydani Maryam Dastoorpur |
| author_facet | Leila Maghsoumi-Norouzabad Maryam Labibzadeh Ahmad Zare Javid Seyed Ahmad Hosseini Gholam Abbas Kaydani Maryam Dastoorpur |
| author_sort | Leila Maghsoumi-Norouzabad |
| collection | DOAJ |
| description | Abstract Background: The prevalence of vitamin D deficiency and male infertility is high in Iran. Objective: The present research aimed to examine the association between serum vitamin D [25(OH)D], parameters of semen including semen volume, sperm count, motility and morphology, and reproductive hormones in infertile Iranian men. Materials and Methods: This was a cross-sectional study on 119 infertile men conducted between September 2018 and May 2019. Subjects were divided into 3 groups based on serum vitamin D levels: deficient ( < 10 ng/mL), insufficient (10 ng/mL ≤ 25(OH)D ≤ 30 ng/mL), and sufficient ( > 30 ng/mL). Body mass index and waist circumference were measured. 25(OH)D, testosterone, sex hormone-binding globulin, luteinizing hormone (LH), follicle-stimulating hormone and estradiol levels, and semen parameters were assessed. Results: The semen volume, sperm counts, total and progressively motile sperm, normal sperm morphology, testosterone levels, and testosterone/estradiol ratio were substantially higher in the sufficient group compared to the other groups (p < 0.001). Also, in the sufficient group, serum LH (p < 0.001) and estradiol (p < 0.001, p = 0.01) were notably lower and serum sex hormone-binding globulin (p < 0.001) and the testosterone/LH ratio (p < 0.001) were considerably higher compared to the insufficient and deficient groups. Conclusion: Our study showed a positive relationship between serum vitamin D levels, and seminal parameters and sex hormones in Iranian infertile males. |
| first_indexed | 2024-04-13T19:03:55Z |
| format | Article |
| id | doaj.art-be5ed23eee1d4a659eb7231894d81564 |
| institution | Directory Open Access Journal |
| issn | 2476-4108 2476-3772 |
| language | English |
| last_indexed | 2024-04-13T19:03:55Z |
| publishDate | 2022-04-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-be5ed23eee1d4a659eb7231894d815642022-12-22T02:34:01ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722022-04-0120433133810.18502/ijrm.v20i4.10905ijrm.v20i4.10905The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional studyLeila Maghsoumi-Norouzabad0Maryam Labibzadeh1Ahmad Zare Javid2Seyed Ahmad Hosseini3Gholam Abbas Kaydani4Maryam Dastoorpur5Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Center of Therapy and Research Infertility Jahad Daneshgahi, Ahvaz, Iran.Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Biostatistics and Epidemiology, Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Abstract Background: The prevalence of vitamin D deficiency and male infertility is high in Iran. Objective: The present research aimed to examine the association between serum vitamin D [25(OH)D], parameters of semen including semen volume, sperm count, motility and morphology, and reproductive hormones in infertile Iranian men. Materials and Methods: This was a cross-sectional study on 119 infertile men conducted between September 2018 and May 2019. Subjects were divided into 3 groups based on serum vitamin D levels: deficient ( < 10 ng/mL), insufficient (10 ng/mL ≤ 25(OH)D ≤ 30 ng/mL), and sufficient ( > 30 ng/mL). Body mass index and waist circumference were measured. 25(OH)D, testosterone, sex hormone-binding globulin, luteinizing hormone (LH), follicle-stimulating hormone and estradiol levels, and semen parameters were assessed. Results: The semen volume, sperm counts, total and progressively motile sperm, normal sperm morphology, testosterone levels, and testosterone/estradiol ratio were substantially higher in the sufficient group compared to the other groups (p < 0.001). Also, in the sufficient group, serum LH (p < 0.001) and estradiol (p < 0.001, p = 0.01) were notably lower and serum sex hormone-binding globulin (p < 0.001) and the testosterone/LH ratio (p < 0.001) were considerably higher compared to the insufficient and deficient groups. Conclusion: Our study showed a positive relationship between serum vitamin D levels, and seminal parameters and sex hormones in Iranian infertile males.https://doi.org/10.18502/ijrm.v20i4.10905infertility, male, vitamin d, semen analysis, gonadal hormones, pituitary hormones. |
| spellingShingle | Leila Maghsoumi-Norouzabad Maryam Labibzadeh Ahmad Zare Javid Seyed Ahmad Hosseini Gholam Abbas Kaydani Maryam Dastoorpur The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study International Journal of Reproductive BioMedicine infertility, male, vitamin d, semen analysis, gonadal hormones, pituitary hormones. |
| title | The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study |
| title_full | The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study |
| title_fullStr | The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study |
| title_full_unstemmed | The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study |
| title_short | The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study |
| title_sort | association of vitamin d semen parameters and reproductive hormones with male infertility a cross sectional study |
| topic | infertility, male, vitamin d, semen analysis, gonadal hormones, pituitary hormones. |
| url | https://doi.org/10.18502/ijrm.v20i4.10905 |
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