Folic Acid-Decorated <i>β</i>-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy
<i>β</i>-cyclodextrin(<i>β</i>CD)-based star polymers have attracted much interest because of their unique structures and potential biomedical and biological applications. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked star polymer ((FA-Dex-SS)-&l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/1/52 |
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| author | Huikang Yang Nianhua Wang Ruimeng Yang Liming Zhang Xinqing Jiang |
| author_facet | Huikang Yang Nianhua Wang Ruimeng Yang Liming Zhang Xinqing Jiang |
| author_sort | Huikang Yang |
| collection | DOAJ |
| description | <i>β</i>-cyclodextrin(<i>β</i>CD)-based star polymers have attracted much interest because of their unique structures and potential biomedical and biological applications. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked star polymer ((FA-Dex-SS)-<i>β</i>CD-(PCL)<sub>14</sub>) was synthesized via a couple reaction between <i>β</i>CD-based 14 arms poly(ε-caprolactone) (<i>β</i>CD-(PCL)<sub>14</sub>) and disulfide-containing α-alkyne dextran (alkyne-SS-Dex), and acted as theranostic nanoparticles for tumor-targeted MRI and chemotherapy. Theranostic nanoparticles were obtained by loading doxorubicin (DOX), and superparamagnetic iron oxide (SPIO) particles were loaded into the star polymer nanoparticles to obtain ((FA-Dex-SS)-<i>β</i>CD-(PCL)<sub>14</sub>@DOX-SPIO) theranostic nanoparticles. In vitro drug release studies showed that approximately 100% of the DOX was released from disulfide bond-linked theranostic nanoparticles within 24 h under a reducing environment in the presence of 10.0 mM GSH. DOX and SPIO could be delivered into HepG2 cells efficiently, owing to the folate receptor-mediated endocytosis process of the nanoparticles and glutathione (GSH), which triggered disulfide-bonds cleaving. Moreover, (FA-Dex-SS)-<i>β</i>CD-(PCL)<sub>14</sub>@DOX-SPIO showed strong MRI contrast enhancement properties. In conclusion, folic acid-decorated reduction-sensitive star polymeric nanoparticles are a potential theranostic nanoparticle candidate for tumor-targeted MRI and chemotherapy. |
| first_indexed | 2024-03-10T00:44:26Z |
| format | Article |
| id | doaj.art-be5f543263b5478aabd5d3de170b1b8d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T00:44:26Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-be5f543263b5478aabd5d3de170b1b8d2023-11-23T15:03:05ZengMDPI AGPharmaceutics1999-49232021-12-011415210.3390/pharmaceutics14010052Folic Acid-Decorated <i>β</i>-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and ChemotherapyHuikang Yang0Nianhua Wang1Ruimeng Yang2Liming Zhang3Xinqing Jiang4Department of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Yuexiu District, Guangzhou 510640, ChinaDepartment of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Yuexiu District, Guangzhou 510640, ChinaDepartment of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Yuexiu District, Guangzhou 510640, ChinaSchool of Materials Science and Engineering, Sun Yat-sen University, Haizhu District, Guangzhou 510275, ChinaDepartment of Radiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Yuexiu District, Guangzhou 510640, China<i>β</i>-cyclodextrin(<i>β</i>CD)-based star polymers have attracted much interest because of their unique structures and potential biomedical and biological applications. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked star polymer ((FA-Dex-SS)-<i>β</i>CD-(PCL)<sub>14</sub>) was synthesized via a couple reaction between <i>β</i>CD-based 14 arms poly(ε-caprolactone) (<i>β</i>CD-(PCL)<sub>14</sub>) and disulfide-containing α-alkyne dextran (alkyne-SS-Dex), and acted as theranostic nanoparticles for tumor-targeted MRI and chemotherapy. Theranostic nanoparticles were obtained by loading doxorubicin (DOX), and superparamagnetic iron oxide (SPIO) particles were loaded into the star polymer nanoparticles to obtain ((FA-Dex-SS)-<i>β</i>CD-(PCL)<sub>14</sub>@DOX-SPIO) theranostic nanoparticles. In vitro drug release studies showed that approximately 100% of the DOX was released from disulfide bond-linked theranostic nanoparticles within 24 h under a reducing environment in the presence of 10.0 mM GSH. DOX and SPIO could be delivered into HepG2 cells efficiently, owing to the folate receptor-mediated endocytosis process of the nanoparticles and glutathione (GSH), which triggered disulfide-bonds cleaving. Moreover, (FA-Dex-SS)-<i>β</i>CD-(PCL)<sub>14</sub>@DOX-SPIO showed strong MRI contrast enhancement properties. In conclusion, folic acid-decorated reduction-sensitive star polymeric nanoparticles are a potential theranostic nanoparticle candidate for tumor-targeted MRI and chemotherapy.https://www.mdpi.com/1999-4923/14/1/52star polymer<i>β</i>-cyclodextrintumor-targeteddisulfide bondtheranostic nanoparticles |
| spellingShingle | Huikang Yang Nianhua Wang Ruimeng Yang Liming Zhang Xinqing Jiang Folic Acid-Decorated <i>β</i>-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy Pharmaceutics star polymer <i>β</i>-cyclodextrin tumor-targeted disulfide bond theranostic nanoparticles |
| title | Folic Acid-Decorated <i>β</i>-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy |
| title_full | Folic Acid-Decorated <i>β</i>-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy |
| title_fullStr | Folic Acid-Decorated <i>β</i>-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy |
| title_full_unstemmed | Folic Acid-Decorated <i>β</i>-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy |
| title_short | Folic Acid-Decorated <i>β</i>-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy |
| title_sort | folic acid decorated i β i cyclodextrin based poly ε caprolactone dextran star polymer with disulfide bond linker as theranostic nanoparticle for tumor targeted mri and chemotherapy |
| topic | star polymer <i>β</i>-cyclodextrin tumor-targeted disulfide bond theranostic nanoparticles |
| url | https://www.mdpi.com/1999-4923/14/1/52 |
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