Brief Report: A Multidisciplinary Initial Workup for Suspected Lung Cancer as Fast-Track Intervention to Histopathologic Diagnosis
Guidelines for optimal timing of lung cancer diagnosis and treatment have been implemented in many countries, but the effect of fast-track interventions on the shortening of time interval is still debatable. In this study, the delay from the first specialist visit to the histopathologic diagnosis wa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | JTO Clinical and Research Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666364323000656 |
| _version_ | 1797795266137423872 |
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| author | Jean-Louis Pujol, MD, PhD Grégoire Mercier, MD, PhD Maria Vasile, MCS Isabelle Serre, MD, PhD Hélène Vernhet-Kovacsik, MD, PhD Sébastien Bommart, MD, PhD |
| author_facet | Jean-Louis Pujol, MD, PhD Grégoire Mercier, MD, PhD Maria Vasile, MCS Isabelle Serre, MD, PhD Hélène Vernhet-Kovacsik, MD, PhD Sébastien Bommart, MD, PhD |
| author_sort | Jean-Louis Pujol, MD, PhD |
| collection | DOAJ |
| description | Guidelines for optimal timing of lung cancer diagnosis and treatment have been implemented in many countries, but the effect of fast-track interventions on the shortening of time interval is still debatable. In this study, the delay from the first specialist visit to the histopathologic diagnosis was compared between two patient cohorts: before (n = 280) and after (n = 247) implementation of a fast-track multidisciplinary diagnosis program. The cumulative incidence function curves were compared, and hazard ratio was adjusted in the Cox model. The implementation allowed a statistically significant increase in the cumulative incidence of the lung cancer histopathologic diagnosis over time. Adjusted hazard ratio for patients accrued in the post-implementation cohort was 1.22 (1.03–1.45) (p = 0.023), corresponding to a reduction of this waiting period by 18%. In conclusion, a multidisciplinary approach of the diagnostic process implemented at the initial visit allows a significant reduction of the timeline until the histopathologic diagnosis of lung cancer. |
| first_indexed | 2024-03-13T03:15:20Z |
| format | Article |
| id | doaj.art-be5fa10ccb474503a25308361debcf48 |
| institution | Directory Open Access Journal |
| issn | 2666-3643 |
| language | English |
| last_indexed | 2024-03-13T03:15:20Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTO Clinical and Research Reports |
| spelling | doaj.art-be5fa10ccb474503a25308361debcf482023-06-26T04:14:52ZengElsevierJTO Clinical and Research Reports2666-36432023-06-0146100526Brief Report: A Multidisciplinary Initial Workup for Suspected Lung Cancer as Fast-Track Intervention to Histopathologic DiagnosisJean-Louis Pujol, MD, PhD0Grégoire Mercier, MD, PhD1Maria Vasile, MCS2Isabelle Serre, MD, PhD3Hélène Vernhet-Kovacsik, MD, PhD4Sébastien Bommart, MD, PhD5Thoracic Oncology Unit, University Hospital of Montpellier, Montpellier, France; Cancerology Resarch Institute of Montpellier (IRCM), National Institute for Health and Medical Research (INSERM) Unit-U1194, Montpellier, France; Corresponding author. Address for correspondence: Jean-Louis Pujol, MD, PhD, University Hospital of Montpellier - Arnaud de Villeneuve Hospital, 371 avenue Doyen Gaston Giraud, 34295 Montpellier, France.Data-Science Unit, University Hospital of Montpellier, Montpellier, France; UMR UA11 Desbrest Institute of Epidemiology and Public Health (IDESP) French National Centre for Scientific Research (CNRS), University of Montpellier, Montpellier, FranceData-Science Unit, University Hospital of Montpellier, Montpellier, FrancePathological Department, University Institute for Clinical Research, Montpellier, FranceDepartment of Medical Imaging, University Hospital of Montpellier, Montpellier, FranceDepartment of Medical Imaging, University Hospital of Montpellier, Montpellier, France; UMR 9214 French National Centre for Scientific Research (CNRS), National Institute for Health and Medical Research (INSERM) U1046, PhyMedExp University of Montpellier, Montpellier, FranceGuidelines for optimal timing of lung cancer diagnosis and treatment have been implemented in many countries, but the effect of fast-track interventions on the shortening of time interval is still debatable. In this study, the delay from the first specialist visit to the histopathologic diagnosis was compared between two patient cohorts: before (n = 280) and after (n = 247) implementation of a fast-track multidisciplinary diagnosis program. The cumulative incidence function curves were compared, and hazard ratio was adjusted in the Cox model. The implementation allowed a statistically significant increase in the cumulative incidence of the lung cancer histopathologic diagnosis over time. Adjusted hazard ratio for patients accrued in the post-implementation cohort was 1.22 (1.03–1.45) (p = 0.023), corresponding to a reduction of this waiting period by 18%. In conclusion, a multidisciplinary approach of the diagnostic process implemented at the initial visit allows a significant reduction of the timeline until the histopathologic diagnosis of lung cancer.http://www.sciencedirect.com/science/article/pii/S2666364323000656 |
| spellingShingle | Jean-Louis Pujol, MD, PhD Grégoire Mercier, MD, PhD Maria Vasile, MCS Isabelle Serre, MD, PhD Hélène Vernhet-Kovacsik, MD, PhD Sébastien Bommart, MD, PhD Brief Report: A Multidisciplinary Initial Workup for Suspected Lung Cancer as Fast-Track Intervention to Histopathologic Diagnosis JTO Clinical and Research Reports |
| title | Brief Report: A Multidisciplinary Initial Workup for Suspected Lung Cancer as Fast-Track Intervention to Histopathologic Diagnosis |
| title_full | Brief Report: A Multidisciplinary Initial Workup for Suspected Lung Cancer as Fast-Track Intervention to Histopathologic Diagnosis |
| title_fullStr | Brief Report: A Multidisciplinary Initial Workup for Suspected Lung Cancer as Fast-Track Intervention to Histopathologic Diagnosis |
| title_full_unstemmed | Brief Report: A Multidisciplinary Initial Workup for Suspected Lung Cancer as Fast-Track Intervention to Histopathologic Diagnosis |
| title_short | Brief Report: A Multidisciplinary Initial Workup for Suspected Lung Cancer as Fast-Track Intervention to Histopathologic Diagnosis |
| title_sort | brief report a multidisciplinary initial workup for suspected lung cancer as fast track intervention to histopathologic diagnosis |
| url | http://www.sciencedirect.com/science/article/pii/S2666364323000656 |
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