Associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home: a prospective observational study
Abstract Background Cancer patients with financial toxicity experience psychological distress and often miss medical appointments and quit treatments early, which could be a barrier to the effective management of oral chemotherapy drugs at home. This study explores whether financial toxicity predict...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-10580-4 |
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| author | Yongfeng Chen Zhenxiang Chen Haiyun Jin Yanrong Chen Jinbing Bai Guifen Fu |
| author_facet | Yongfeng Chen Zhenxiang Chen Haiyun Jin Yanrong Chen Jinbing Bai Guifen Fu |
| author_sort | Yongfeng Chen |
| collection | DOAJ |
| description | Abstract Background Cancer patients with financial toxicity experience psychological distress and often miss medical appointments and quit treatments early, which could be a barrier to the effective management of oral chemotherapy drugs at home. This study explores whether financial toxicity predicts symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home, which will contribute to the safe management of oral chemotherapy. Methods Data in this study was from a prospective observational study, which was conducted between October 2018 and December 2019. 151 patients completed the Comprehensive Score for Financial Toxicity at discharge and completed the MD Anderson Symptom Inventory and unplanned healthcare utilization questionnaires after finishing one cycle of oral chemotherapy at home. Regression analyses were conducted to explore the associations of financial toxicity with symptoms and unplanned healthcare utilization. Results Among 151participants, 88.08% reported severe or moderate financial toxicity, 43.05% reported symptom interference, and 31.79% reported unplanned healthcare utilization while taking oral chemotherapy at home. Patients between the age of 45-60y (p = 0.042) have higher financial toxicity, while those living in urban areas (p = 0.016) have lower financial toxicity. Patients with worse financial toxicity suffered increased symptoms of fatigue, emotional distress, disturbed sleep, and lack of appetite. Consequently, their mood and personal relation with other significant suffered. However, no statistical differences in unplanned healthcare utilization were found among patients with different levels of financial toxicity. Conclusion Middle-aged adults and those living in suburban or rural areas experienced worse financial toxicity than other groups. Patients with worse financial toxicity experienced more severe psychological symptoms (e.g., fatigue, distress, disturbed sleep, and lack of appetite) and affective interference (e.g., mood and relations with others). Identifying at-risk patients is necessary to offer tailored support for psychological symptom management. |
| first_indexed | 2024-04-10T15:43:30Z |
| format | Article |
| id | doaj.art-be602ee1d902459e8154f62fd42c2808 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-10T15:43:30Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-be602ee1d902459e8154f62fd42c28082023-02-12T12:14:48ZengBMCBMC Cancer1471-24072023-02-0123111110.1186/s12885-023-10580-4Associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home: a prospective observational studyYongfeng Chen0Zhenxiang Chen1Haiyun Jin2Yanrong Chen3Jinbing Bai4Guifen Fu5Nursing Department, The People’s Hospital of Guangxi Zhuang Autonomous RegionThe Department of Chemotherapy, The People’s Hospital of Guangxi Zhuang Autonomous RegionThe Department of Chemotherapy, The People’s Hospital of Guangxi Zhuang Autonomous RegionThe Department of Chemotherapy, The People’s Hospital of Guangxi Zhuang Autonomous RegionNell Hodgson Woodruff School of Nursing, Emory UniversityNursing Department, The People’s Hospital of Guangxi Zhuang Autonomous RegionAbstract Background Cancer patients with financial toxicity experience psychological distress and often miss medical appointments and quit treatments early, which could be a barrier to the effective management of oral chemotherapy drugs at home. This study explores whether financial toxicity predicts symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home, which will contribute to the safe management of oral chemotherapy. Methods Data in this study was from a prospective observational study, which was conducted between October 2018 and December 2019. 151 patients completed the Comprehensive Score for Financial Toxicity at discharge and completed the MD Anderson Symptom Inventory and unplanned healthcare utilization questionnaires after finishing one cycle of oral chemotherapy at home. Regression analyses were conducted to explore the associations of financial toxicity with symptoms and unplanned healthcare utilization. Results Among 151participants, 88.08% reported severe or moderate financial toxicity, 43.05% reported symptom interference, and 31.79% reported unplanned healthcare utilization while taking oral chemotherapy at home. Patients between the age of 45-60y (p = 0.042) have higher financial toxicity, while those living in urban areas (p = 0.016) have lower financial toxicity. Patients with worse financial toxicity suffered increased symptoms of fatigue, emotional distress, disturbed sleep, and lack of appetite. Consequently, their mood and personal relation with other significant suffered. However, no statistical differences in unplanned healthcare utilization were found among patients with different levels of financial toxicity. Conclusion Middle-aged adults and those living in suburban or rural areas experienced worse financial toxicity than other groups. Patients with worse financial toxicity experienced more severe psychological symptoms (e.g., fatigue, distress, disturbed sleep, and lack of appetite) and affective interference (e.g., mood and relations with others). Identifying at-risk patients is necessary to offer tailored support for psychological symptom management.https://doi.org/10.1186/s12885-023-10580-4Oral chemotherapyFinancial toxicitySymptomsUnplanned healthcare utilizationCancer |
| spellingShingle | Yongfeng Chen Zhenxiang Chen Haiyun Jin Yanrong Chen Jinbing Bai Guifen Fu Associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home: a prospective observational study BMC Cancer Oral chemotherapy Financial toxicity Symptoms Unplanned healthcare utilization Cancer |
| title | Associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home: a prospective observational study |
| title_full | Associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home: a prospective observational study |
| title_fullStr | Associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home: a prospective observational study |
| title_full_unstemmed | Associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home: a prospective observational study |
| title_short | Associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home: a prospective observational study |
| title_sort | associations of financial toxicity with symptoms and unplanned healthcare utilization among cancer patients taking oral chemotherapy at home a prospective observational study |
| topic | Oral chemotherapy Financial toxicity Symptoms Unplanned healthcare utilization Cancer |
| url | https://doi.org/10.1186/s12885-023-10580-4 |
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