NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial
Cardiovascular comorbidities and immune-response dysregulation are associated with COVID-19 severity. We aimed to explore the key immune cell profile and understand its association with disease progression in 156 patients with hypertension that were hospitalized due to COVID-19. The primary outcome...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/13/3713 |
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| author | Renata Moll-Bernardes Sérgio C. Fortier Andréa S. Sousa Renato D. Lopes Narendra Vera Luciana Conde André Feldman Guilherme Arruda Mauro Cabral-Castro Denílson C. Albuquerque Thiago C. Paula Thyago Furquim Vitor A. Loures Karla Giusti Nathália Oliveira Ariane Macedo Pedro Barros e Silva Fábio De Luca Marisol Kotsugai Rafael Domiciano Flávia A. Silva Mayara F. Santos Olga F. Souza Fernando A. Bozza Ronir R. Luiz Emiliano Medei |
| author_facet | Renata Moll-Bernardes Sérgio C. Fortier Andréa S. Sousa Renato D. Lopes Narendra Vera Luciana Conde André Feldman Guilherme Arruda Mauro Cabral-Castro Denílson C. Albuquerque Thiago C. Paula Thyago Furquim Vitor A. Loures Karla Giusti Nathália Oliveira Ariane Macedo Pedro Barros e Silva Fábio De Luca Marisol Kotsugai Rafael Domiciano Flávia A. Silva Mayara F. Santos Olga F. Souza Fernando A. Bozza Ronir R. Luiz Emiliano Medei |
| author_sort | Renata Moll-Bernardes |
| collection | DOAJ |
| description | Cardiovascular comorbidities and immune-response dysregulation are associated with COVID-19 severity. We aimed to explore the key immune cell profile and understand its association with disease progression in 156 patients with hypertension that were hospitalized due to COVID-19. The primary outcome was progression to severe disease. The probability of progression to severe disease was estimated using a logistic regression model that included clinical variables and immune cell subsets associated with the primary outcome. Obesity; diabetes; oxygen saturation; lung involvement on computed tomography (CT) examination; the C-reactive protein concentration; total lymphocyte count; proportions of CD4+ and CD8+ T cells; CD4/CD8 ratio; CD8+ HLA-DR MFI; and CD8+ NKG2A MFI on admission were all associated with progression to severe COVID-19. This study demonstrated that increased CD8+ NKG2A MFI at hospital admission, in combination with some clinical variables, is associated with a high risk of COVID-19 progression in hypertensive patients. These findings reinforce the hypothesis of the functional exhaustion of T cells with the increased expression of NKG2A in patients with severe COVID-19, elucidating how severe acute respiratory syndrome coronavirus 2 infection may break down the innate antiviral immune response at an early stage of the disease, with future potential therapeutic implications. |
| first_indexed | 2024-03-09T04:04:56Z |
| format | Article |
| id | doaj.art-be60eb8d03444dd0934e1ae5d6b2028d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:04:56Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-be60eb8d03444dd0934e1ae5d6b2028d2023-12-03T14:07:50ZengMDPI AGJournal of Clinical Medicine2077-03832022-06-011113371310.3390/jcm11133713NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized TrialRenata Moll-Bernardes0Sérgio C. Fortier1Andréa S. Sousa2Renato D. Lopes3Narendra Vera4Luciana Conde5André Feldman6Guilherme Arruda7Mauro Cabral-Castro8Denílson C. Albuquerque9Thiago C. Paula10Thyago Furquim11Vitor A. Loures12Karla Giusti13Nathália Oliveira14Ariane Macedo15Pedro Barros e Silva16Fábio De Luca17Marisol Kotsugai18Rafael Domiciano19Flávia A. Silva20Mayara F. Santos21Olga F. Souza22Fernando A. Bozza23Ronir R. Luiz24Emiliano Medei25D’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-170, BrazilInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-170, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilInstitute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilBrazilian Clinical Research Institute, São Paulo 01404-000, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilD’Or Institute for Research and Education, Rio de Janeiro 22281-100, BrazilCardiovascular comorbidities and immune-response dysregulation are associated with COVID-19 severity. We aimed to explore the key immune cell profile and understand its association with disease progression in 156 patients with hypertension that were hospitalized due to COVID-19. The primary outcome was progression to severe disease. The probability of progression to severe disease was estimated using a logistic regression model that included clinical variables and immune cell subsets associated with the primary outcome. Obesity; diabetes; oxygen saturation; lung involvement on computed tomography (CT) examination; the C-reactive protein concentration; total lymphocyte count; proportions of CD4+ and CD8+ T cells; CD4/CD8 ratio; CD8+ HLA-DR MFI; and CD8+ NKG2A MFI on admission were all associated with progression to severe COVID-19. This study demonstrated that increased CD8+ NKG2A MFI at hospital admission, in combination with some clinical variables, is associated with a high risk of COVID-19 progression in hypertensive patients. These findings reinforce the hypothesis of the functional exhaustion of T cells with the increased expression of NKG2A in patients with severe COVID-19, elucidating how severe acute respiratory syndrome coronavirus 2 infection may break down the innate antiviral immune response at an early stage of the disease, with future potential therapeutic implications.https://www.mdpi.com/2077-0383/11/13/3713COVID-19NKG2AHLA-DRT cellhypertensionimmune response |
| spellingShingle | Renata Moll-Bernardes Sérgio C. Fortier Andréa S. Sousa Renato D. Lopes Narendra Vera Luciana Conde André Feldman Guilherme Arruda Mauro Cabral-Castro Denílson C. Albuquerque Thiago C. Paula Thyago Furquim Vitor A. Loures Karla Giusti Nathália Oliveira Ariane Macedo Pedro Barros e Silva Fábio De Luca Marisol Kotsugai Rafael Domiciano Flávia A. Silva Mayara F. Santos Olga F. Souza Fernando A. Bozza Ronir R. Luiz Emiliano Medei NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial Journal of Clinical Medicine COVID-19 NKG2A HLA-DR T cell hypertension immune response |
| title | NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title_full | NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title_fullStr | NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title_full_unstemmed | NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title_short | NKG2A Expression among CD8 Cells Is Associated with COVID-19 Progression in Hypertensive Patients: Insights from the BRACE CORONA Randomized Trial |
| title_sort | nkg2a expression among cd8 cells is associated with covid 19 progression in hypertensive patients insights from the brace corona randomized trial |
| topic | COVID-19 NKG2A HLA-DR T cell hypertension immune response |
| url | https://www.mdpi.com/2077-0383/11/13/3713 |
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