AS1411-functionalized delivery nanosystems for targeted cancer therapy
Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications. These characteristics of NCL make it an ideal t...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2021-04-01
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| Series: | Exploration of Medicine |
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| Online Access: | https://www.explorationpub.com/Journals/em/Article/100139 |
| _version_ | 1818926098448121856 |
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| author | Pooria Safarzadeh Kozani Pouya Safarzadeh Kozani Mohammad Tariq Malik |
| author_facet | Pooria Safarzadeh Kozani Pouya Safarzadeh Kozani Mohammad Tariq Malik |
| author_sort | Pooria Safarzadeh Kozani |
| collection | DOAJ |
| description | Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications. These characteristics of NCL make it an ideal target for the treatment of various cancers. AS1411 is a synthetic quadruplex-forming nuclease-resistant DNA oligonucleotide aptamer which shows a considerably high affinity for NCL, therefore, being capable of inducing growth inhibition in a variety of tumor cells. The high affinity and specificity of AS1411 towards NCL make it a suitable targeting tool, which can be used for the functionalization of therapeutic payload-delivery nanosystems to selectively target tumor cells. This review explores the advances in NCL-targeting cancer therapy through AS1411-functionalized delivery nanosystems for the selective delivery of a broad spectrum of therapeutic agents. |
| first_indexed | 2024-12-20T02:51:43Z |
| format | Article |
| id | doaj.art-be66329843aa42cab52f317b09f43920 |
| institution | Directory Open Access Journal |
| issn | 2692-3106 |
| language | English |
| last_indexed | 2024-12-20T02:51:43Z |
| publishDate | 2021-04-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj.art-be66329843aa42cab52f317b09f439202022-12-21T19:56:01ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062021-04-012214616610.37349/emed.2021.00039AS1411-functionalized delivery nanosystems for targeted cancer therapyPooria Safarzadeh Kozani0https://orcid.org/0000-0002-9901-7851Pouya Safarzadeh Kozani1https://orcid.org/0000-0002-2602-3871Mohammad Tariq Malik2Carlos Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115/111, IranDepartment of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht 41446/66949, Iran; Student Research Committee, Medical Biotechnology Research Center, School of Nursing, Midwifery, and Paramedicine, Guilan University of Medical Sciences, Rasht 41446/66949, IranDepartments of Microbiology and Immunology, Regenerative Medicine, and Stem Cell Biology, University of Louisville, Louisville, KY 40202, USA; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USANucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications. These characteristics of NCL make it an ideal target for the treatment of various cancers. AS1411 is a synthetic quadruplex-forming nuclease-resistant DNA oligonucleotide aptamer which shows a considerably high affinity for NCL, therefore, being capable of inducing growth inhibition in a variety of tumor cells. The high affinity and specificity of AS1411 towards NCL make it a suitable targeting tool, which can be used for the functionalization of therapeutic payload-delivery nanosystems to selectively target tumor cells. This review explores the advances in NCL-targeting cancer therapy through AS1411-functionalized delivery nanosystems for the selective delivery of a broad spectrum of therapeutic agents.https://www.explorationpub.com/Journals/em/Article/100139nucleolinas1411aptamercancernanoparticlesdrug delivery |
| spellingShingle | Pooria Safarzadeh Kozani Pouya Safarzadeh Kozani Mohammad Tariq Malik AS1411-functionalized delivery nanosystems for targeted cancer therapy Exploration of Medicine nucleolin as1411 aptamer cancer nanoparticles drug delivery |
| title | AS1411-functionalized delivery nanosystems for targeted cancer therapy |
| title_full | AS1411-functionalized delivery nanosystems for targeted cancer therapy |
| title_fullStr | AS1411-functionalized delivery nanosystems for targeted cancer therapy |
| title_full_unstemmed | AS1411-functionalized delivery nanosystems for targeted cancer therapy |
| title_short | AS1411-functionalized delivery nanosystems for targeted cancer therapy |
| title_sort | as1411 functionalized delivery nanosystems for targeted cancer therapy |
| topic | nucleolin as1411 aptamer cancer nanoparticles drug delivery |
| url | https://www.explorationpub.com/Journals/em/Article/100139 |
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