Ca ion transport in smooth muscle mitochondria
Review focuses on the analysis of literature data and own results concerning properties of mitochondria Са2+ transporting systems and their regulation. Three mechanisms for mitochondrial Ca2+ uptake are described: the electrogenic mitochondrial Ca2+ uniporter, a rapid mode of Ca2+ uptake (RaM) and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2014-12-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Babich_6_14.pdf |
| _version_ | 1797668791126065152 |
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| author | L. G. Babich S. G. Shlykov S. O. Kosterin |
| author_facet | L. G. Babich S. G. Shlykov S. O. Kosterin |
| author_sort | L. G. Babich |
| collection | DOAJ |
| description | Review focuses on the analysis of literature data and own results concerning properties of mitochondria Са2+ transporting systems and their regulation. Three mechanisms for mitochondrial Ca2+ uptake are described: the electrogenic mitochondrial Ca2+ uniporter, a rapid mode of Ca2+ uptake (RaM) and ryanodine-sensitive Ca2+ channels (RyR). Two mechanisms of Ca2+ efflux from the mitochondrial matrix have been proposed: Na+-dependent and Na+-independent Ca2+ exchange. The mitochondrial permeability transition pore can also function as a Ca2+ efflux mechanism. Ca2+ accumulation in mitochondria resulted in an increase of mitochondrial membrane potential, ATP synthesis and activation of metabolites transport. The dissipation of mitochondrial membrane potential should prevent mitochondrial Ca2+ uptake. Our data concerning depolarizing effect of calmodulin antagonists and hyperpolarizing effect of calix[4]arenes С-136 and С-137 on the myometrium mitochondria can be applied on the demand of mitochondria membrane potential correction. |
| first_indexed | 2024-03-11T20:34:37Z |
| format | Article |
| id | doaj.art-be666391fdd844fea8b19c282fc26053 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T20:34:37Z |
| publishDate | 2014-12-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-be666391fdd844fea8b19c282fc260532023-10-02T07:19:23ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032014-12-01866183010.15407/ubj86.06.018Ca ion transport in smooth muscle mitochondriaL. G. Babich0S. G. Shlykov1 S. O. Kosterin2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivPalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivPalladin Institute of Biochemistry, National Academy of Sciences of Ukraine, KyivReview focuses on the analysis of literature data and own results concerning properties of mitochondria Са2+ transporting systems and their regulation. Three mechanisms for mitochondrial Ca2+ uptake are described: the electrogenic mitochondrial Ca2+ uniporter, a rapid mode of Ca2+ uptake (RaM) and ryanodine-sensitive Ca2+ channels (RyR). Two mechanisms of Ca2+ efflux from the mitochondrial matrix have been proposed: Na+-dependent and Na+-independent Ca2+ exchange. The mitochondrial permeability transition pore can also function as a Ca2+ efflux mechanism. Ca2+ accumulation in mitochondria resulted in an increase of mitochondrial membrane potential, ATP synthesis and activation of metabolites transport. The dissipation of mitochondrial membrane potential should prevent mitochondrial Ca2+ uptake. Our data concerning depolarizing effect of calmodulin antagonists and hyperpolarizing effect of calix[4]arenes С-136 and С-137 on the myometrium mitochondria can be applied on the demand of mitochondria membrane potential correction.http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Babich_6_14.pdfmitochondriasmooth musclesСа(2+) transporting systems |
| spellingShingle | L. G. Babich S. G. Shlykov S. O. Kosterin Ca ion transport in smooth muscle mitochondria The Ukrainian Biochemical Journal mitochondria smooth muscles Са(2+) transporting systems |
| title | Ca ion transport in smooth muscle mitochondria |
| title_full | Ca ion transport in smooth muscle mitochondria |
| title_fullStr | Ca ion transport in smooth muscle mitochondria |
| title_full_unstemmed | Ca ion transport in smooth muscle mitochondria |
| title_short | Ca ion transport in smooth muscle mitochondria |
| title_sort | ca ion transport in smooth muscle mitochondria |
| topic | mitochondria smooth muscles Са(2+) transporting systems |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2015/06/Babich_6_14.pdf |
| work_keys_str_mv | AT lgbabich caiontransportinsmoothmusclemitochondria AT sgshlykov caiontransportinsmoothmusclemitochondria AT sokosterin caiontransportinsmoothmusclemitochondria |