Donor γδT Cells Promote GVL Effect and Mitigate aGVHD in Allogeneic Hematopoietic Stem Cell Transplantation

Donor γδT Cells Promote GVL Effect and Mitigate aGVHD in Allogeneic Hematopoietic Stem Cell Transplantation

Disease relapse and graft-versus-host disease (GVHD) are the major complications affecting the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT). While the functions of αβT cells are extensively studied, the role of donor γδT cells in allo-HSCT is less well defined. Using TC...

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Bibliographic Details
Main Authors: Yuan Song, Ying Zhu, Bo Hu, Yonghao Liu, Dandan Lin, Ziqi Jin, Zhinan Yin, Chen Dong, Depei Wu, Haiyan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
γδT cells
IL-17
graft-versus-host disease
graft-versus-leukemia
hematopoietic stem cell transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.558143/full

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