Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave

<i>Background and objectives</i>: early reports showed a decrease in admission rates and an increase in mortality of patients with acute myocardial infarction (AMI) during the first wave of COVID-19 pandemic. We sought to investigate whether the COVID-19 pandemic and associated lockdown...

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Main Authors: Povilas Budrys, Mindaugas Lizaitis, Kamile Cerlinskaite-Bajore, Vilhelmas Bajoras, Greta Rodevic, Aurelija Martinonyte, Laurynas Dieckus, Ignas Badaras, Pranas Serpytis, Romualdas Gurevicius, Rasa Visinskiene, Romualdas Buivydas, Aleksandr Volodko, Egle Urbonaite, Jelena Celutkiene, Giedrius Davidavicius
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Medicina
Subjects:
Online Access:https://www.mdpi.com/1648-9144/57/12/1296
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author Povilas Budrys
Mindaugas Lizaitis
Kamile Cerlinskaite-Bajore
Vilhelmas Bajoras
Greta Rodevic
Aurelija Martinonyte
Laurynas Dieckus
Ignas Badaras
Pranas Serpytis
Romualdas Gurevicius
Rasa Visinskiene
Romualdas Buivydas
Aleksandr Volodko
Egle Urbonaite
Jelena Celutkiene
Giedrius Davidavicius
author_facet Povilas Budrys
Mindaugas Lizaitis
Kamile Cerlinskaite-Bajore
Vilhelmas Bajoras
Greta Rodevic
Aurelija Martinonyte
Laurynas Dieckus
Ignas Badaras
Pranas Serpytis
Romualdas Gurevicius
Rasa Visinskiene
Romualdas Buivydas
Aleksandr Volodko
Egle Urbonaite
Jelena Celutkiene
Giedrius Davidavicius
author_sort Povilas Budrys
collection DOAJ
description <i>Background and objectives</i>: early reports showed a decrease in admission rates and an increase in mortality of patients with acute myocardial infarction (AMI) during the first wave of COVID-19 pandemic. We sought to investigate whether the COVID-19 pandemic and associated lockdown had an impact on the ischemia time and prognosis of patients suffering from AMI in the settings of low COVID-19 burden. <i>Materials and Methods:</i> we conducted a retrospective data analysis from a tertiary center in Lithuania of 818 patients with AMI. Data were collected from 1 March to 30 June in 2020 during the peri-lockdown period (2020 group; <i>n</i> = 278) and compared to the same period last year (2019 group; <i>n</i> = 326). The primary study endpoint was all-cause mortality during 3 months of follow-up. Secondary endpoints were heart failure severity (Killip class) on admission and ischemia time in patients with acute ST segment elevation myocardial infarction (STEMI). <i>Results:</i> there was a reduction of 14.7% in admission rate for acute myocardial infarction (AMI) during the peri-lockdown period. The 3-month mortality rate did not differ significantly (6.9% in 2020 vs. 10.5% in 2019, <i>p</i> = 0.341 for STEMI patients; 5.3% in 2020 vs. 2.6% in 2019, <i>p</i> = 0.374 for patients with acute myocardial infarction without ST segment elevation (NSTEMI)). More STEMI patients presented with Killip IV class in 2019 (13.5% vs. 5.5%, <i>p</i> = 0.043, respectively). There was an increase of door-to-PCI time (54.0 [42.0–86.0] in 2019; 63.5 [48.3–97.5] in 2020, <i>p</i> = 0.018) and first medical contact (FMC)-to-PCI time (101.0 [82.5–120.8] in 2019; 115 [97.0–154.5] in 2020, <i>p</i> = 0.01) during the pandemic period. <i>Conclusions:</i> There was a 14.7% reduction of admissions for AMI during the first wave of COVID-19. FMC-to-PCI time increased during the peri-lockdown period, however, it did not translate into worse survival during follow-up.
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spelling doaj.art-be66ca17d8e6445da9691d8aaf358d922023-11-23T09:28:00ZengMDPI AGMedicina1010-660X1648-91442021-11-015712129610.3390/medicina57121296Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic WavePovilas Budrys0Mindaugas Lizaitis1Kamile Cerlinskaite-Bajore2Vilhelmas Bajoras3Greta Rodevic4Aurelija Martinonyte5Laurynas Dieckus6Ignas Badaras7Pranas Serpytis8Romualdas Gurevicius9Rasa Visinskiene10Romualdas Buivydas11Aleksandr Volodko12Egle Urbonaite13Jelena Celutkiene14Giedrius Davidavicius15Clinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaCardiology and Angiology Center, Vilnius University Hospital Santaros Klinikos, 08410 Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaFaculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaFaculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaCenter for Health Statistics, Institute of Hygiene, 01128 Vilnius, LithuaniaNational Health Insurance Fund under the Ministry of Health, 09307 Vilnius, LithuaniaHealth Economics Centre, 10306 Vilnius, LithuaniaEmergency Medical Services Station, 05131 Vilnius, LithuaniaCardiology and Angiology Center, Vilnius University Hospital Santaros Klinikos, 08410 Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, LithuaniaClinic of Cardiac and Vascular Diseases, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania<i>Background and objectives</i>: early reports showed a decrease in admission rates and an increase in mortality of patients with acute myocardial infarction (AMI) during the first wave of COVID-19 pandemic. We sought to investigate whether the COVID-19 pandemic and associated lockdown had an impact on the ischemia time and prognosis of patients suffering from AMI in the settings of low COVID-19 burden. <i>Materials and Methods:</i> we conducted a retrospective data analysis from a tertiary center in Lithuania of 818 patients with AMI. Data were collected from 1 March to 30 June in 2020 during the peri-lockdown period (2020 group; <i>n</i> = 278) and compared to the same period last year (2019 group; <i>n</i> = 326). The primary study endpoint was all-cause mortality during 3 months of follow-up. Secondary endpoints were heart failure severity (Killip class) on admission and ischemia time in patients with acute ST segment elevation myocardial infarction (STEMI). <i>Results:</i> there was a reduction of 14.7% in admission rate for acute myocardial infarction (AMI) during the peri-lockdown period. The 3-month mortality rate did not differ significantly (6.9% in 2020 vs. 10.5% in 2019, <i>p</i> = 0.341 for STEMI patients; 5.3% in 2020 vs. 2.6% in 2019, <i>p</i> = 0.374 for patients with acute myocardial infarction without ST segment elevation (NSTEMI)). More STEMI patients presented with Killip IV class in 2019 (13.5% vs. 5.5%, <i>p</i> = 0.043, respectively). There was an increase of door-to-PCI time (54.0 [42.0–86.0] in 2019; 63.5 [48.3–97.5] in 2020, <i>p</i> = 0.018) and first medical contact (FMC)-to-PCI time (101.0 [82.5–120.8] in 2019; 115 [97.0–154.5] in 2020, <i>p</i> = 0.01) during the pandemic period. <i>Conclusions:</i> There was a 14.7% reduction of admissions for AMI during the first wave of COVID-19. FMC-to-PCI time increased during the peri-lockdown period, however, it did not translate into worse survival during follow-up.https://www.mdpi.com/1648-9144/57/12/1296COVID-19myocardial infarctionischemia timepercutaneous coronary intervention
spellingShingle Povilas Budrys
Mindaugas Lizaitis
Kamile Cerlinskaite-Bajore
Vilhelmas Bajoras
Greta Rodevic
Aurelija Martinonyte
Laurynas Dieckus
Ignas Badaras
Pranas Serpytis
Romualdas Gurevicius
Rasa Visinskiene
Romualdas Buivydas
Aleksandr Volodko
Egle Urbonaite
Jelena Celutkiene
Giedrius Davidavicius
Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
Medicina
COVID-19
myocardial infarction
ischemia time
percutaneous coronary intervention
title Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_full Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_fullStr Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_full_unstemmed Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_short Increase of Myocardial Ischemia Time and Short-Term Prognosis of Patients with Acute Myocardial Infarction during the First COVID-19 Pandemic Wave
title_sort increase of myocardial ischemia time and short term prognosis of patients with acute myocardial infarction during the first covid 19 pandemic wave
topic COVID-19
myocardial infarction
ischemia time
percutaneous coronary intervention
url https://www.mdpi.com/1648-9144/57/12/1296
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