Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features
BackgroundMyeloid sarcoma (MS) is a rare hematological malignancy characterized by the formation of a solid mass of myeloblasts outside the bone marrow, such as in the lymph nodes, skin, or bone. MS may arise de novo or concurrently with acute myeloid leukemia (AML), myeloproliferative neoplasm (MPN...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1268617/full |
| _version_ | 1797351651960422400 |
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| author | Li Chun Zhen Zeng Qianyu Guo Qianyu Guo Yangjun He |
| author_facet | Li Chun Zhen Zeng Qianyu Guo Qianyu Guo Yangjun He |
| author_sort | Li Chun |
| collection | DOAJ |
| description | BackgroundMyeloid sarcoma (MS) is a rare hematological malignancy characterized by the formation of a solid mass of myeloblasts outside the bone marrow, such as in the lymph nodes, skin, or bone. MS may arise de novo or concurrently with acute myeloid leukemia (AML), myeloproliferative neoplasm (MPN), or myelodysplastic syndrome (MDS). MS accounts for less than 1% of extramedullary acute myeloid leukemia cases. Phyllodes tumors (PTs) are a rare fibroepithelial breast tumor that can be benign, malignant, or borderline, and account for less than 1% of all breast cancers.Case presentationWe present a unique case of a 50-year-old woman with both breast MS and borderline PT with malignant features, which presented a diagnostic challenge. The patient initially presented with a mass in her right breast, and the initial fine-needle biopsy revealed the presence of immature myeloperoxidase (MPO)+ myeloid cells consistent with MS. Subsequent pathological analysis of tumor tissues after neoadjuvant radiotherapy and chemotherapy showed a borderline PT with malignant features. Following excision of the tumor, the patient experienced a local recurrence, which was also surgically removed. At 8 months post-surgery, the patient remains free of recurrence under close follow-up.ConclusionThis case highlights the importance of considering the possibility of concurrent malignancies in the differential diagnosis of complex breast masses and underscores the challenges involved in diagnosing and managing such cases. Additionally, we also emphasize the value of neoadjuvant radiotherapy and chemotherapy in MS. |
| first_indexed | 2024-03-08T13:03:36Z |
| format | Article |
| id | doaj.art-be677f3009a2463f95f5764c8738bb7a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T13:03:36Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-be677f3009a2463f95f5764c8738bb7a2024-01-19T04:25:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.12686171268617Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant featuresLi Chun0Zhen Zeng1Qianyu Guo2Qianyu Guo3Yangjun He4Department of Integrative Oncology (Rehabilitation Technology), Sichuan Nursing Vocational College, Chengdu, ChinaDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United StatesRobert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, United StatesDepartment of Breast Surgery, Chengdu Seventh People’s Hospital, Chengdu, ChinaBackgroundMyeloid sarcoma (MS) is a rare hematological malignancy characterized by the formation of a solid mass of myeloblasts outside the bone marrow, such as in the lymph nodes, skin, or bone. MS may arise de novo or concurrently with acute myeloid leukemia (AML), myeloproliferative neoplasm (MPN), or myelodysplastic syndrome (MDS). MS accounts for less than 1% of extramedullary acute myeloid leukemia cases. Phyllodes tumors (PTs) are a rare fibroepithelial breast tumor that can be benign, malignant, or borderline, and account for less than 1% of all breast cancers.Case presentationWe present a unique case of a 50-year-old woman with both breast MS and borderline PT with malignant features, which presented a diagnostic challenge. The patient initially presented with a mass in her right breast, and the initial fine-needle biopsy revealed the presence of immature myeloperoxidase (MPO)+ myeloid cells consistent with MS. Subsequent pathological analysis of tumor tissues after neoadjuvant radiotherapy and chemotherapy showed a borderline PT with malignant features. Following excision of the tumor, the patient experienced a local recurrence, which was also surgically removed. At 8 months post-surgery, the patient remains free of recurrence under close follow-up.ConclusionThis case highlights the importance of considering the possibility of concurrent malignancies in the differential diagnosis of complex breast masses and underscores the challenges involved in diagnosing and managing such cases. Additionally, we also emphasize the value of neoadjuvant radiotherapy and chemotherapy in MS.https://www.frontiersin.org/articles/10.3389/fonc.2023.1268617/fullbreast cancermyeloid sarcoma (MS)borderline phyllodes tumor with malignant featuresneoadjuvant radiotherapyneoadjuvant chemotherapy |
| spellingShingle | Li Chun Zhen Zeng Qianyu Guo Qianyu Guo Yangjun He Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features Frontiers in Oncology breast cancer myeloid sarcoma (MS) borderline phyllodes tumor with malignant features neoadjuvant radiotherapy neoadjuvant chemotherapy |
| title | Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features |
| title_full | Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features |
| title_fullStr | Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features |
| title_full_unstemmed | Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features |
| title_short | Case report: The first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features |
| title_sort | case report the first case of concurrent breast myeloid sarcoma and borderline phyllodes tumor with malignant features |
| topic | breast cancer myeloid sarcoma (MS) borderline phyllodes tumor with malignant features neoadjuvant radiotherapy neoadjuvant chemotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1268617/full |
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