Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline
Individuals with subjective cognitive decline (SCD) are at higher risk of incipient Alzheimer's disease (AD). Spatial navigation (SN) impairments in AD dementia and mild cognitive impairment patients have been well-documented; however, studies investigating SN deficits in SCD subjects are still...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.596025/full |
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| author | Qian Chen Sichu Wu Xin Li Yi Sun Wenqian Chen Jiaming Lu Wen Zhang Jiani Liu Zhao Qing Zhao Qing Zuzana Nedelska Zuzana Nedelska Jakub Hort Jakub Hort Xin Zhang Xin Zhang Bing Zhang Bing Zhang Bing Zhang |
| author_facet | Qian Chen Sichu Wu Xin Li Yi Sun Wenqian Chen Jiaming Lu Wen Zhang Jiani Liu Zhao Qing Zhao Qing Zuzana Nedelska Zuzana Nedelska Jakub Hort Jakub Hort Xin Zhang Xin Zhang Bing Zhang Bing Zhang Bing Zhang |
| author_sort | Qian Chen |
| collection | DOAJ |
| description | Individuals with subjective cognitive decline (SCD) are at higher risk of incipient Alzheimer's disease (AD). Spatial navigation (SN) impairments in AD dementia and mild cognitive impairment patients have been well-documented; however, studies investigating SN deficits in SCD subjects are still lacking. This study aimed to explore whether basal forebrain (BF) and entorhinal cortex (EC) atrophy contribute to spatial disorientation in the SCD stage. In total, 31 SCD subjects and 24 normal controls were enrolled and administered cognitive scales, a 2-dimensional computerized SN test, and structural magnetic resonance imaging (MRI) scanning. We computed the differences in navigation distance errors and volumes of BF subfields, EC, and hippocampus between the SCD and control groups. The correlations between MRI volumetry and navigation distance errors were also calculated. Compared with the controls, the SCD subjects performed worse in both egocentric and allocentric navigation. The SCD group showed volume reductions in the whole BF (p < 0.05, uncorrected) and the Ch4p subfield (p < 0.05, Bonferroni corrected), but comparable EC and hippocampal volumes with the controls. In the SCD cohort, the allocentric errors were negatively correlated with total BF (r = −0.625, p < 0.001), Ch4p (r = −0.625, p < 0.001), total EC (r = −0.423, p = 0.031), and left EC volumes (r = −0.442, p = 0.024), adjusting for age, gender, years of education, total intracranial volume, and hippocampal volume. This study demonstrates that SN deficits and BF atrophy may be promising indicators for the early detection of incipient AD patients. The reduced BF volume, especially in the Ch4p subfield, may serve as a structural basis for allocentric disorientation in SCD subjects independent of hippocampal atrophy. Our findings may have further implications for the preclinical diagnosis and intervention for potential AD patients. |
| first_indexed | 2024-12-20T11:14:16Z |
| format | Article |
| id | doaj.art-be680d45c97e4134a4d6e517f4dce395 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-20T11:14:16Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-be680d45c97e4134a4d6e517f4dce3952022-12-21T19:42:40ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-02-011310.3389/fnagi.2021.596025596025Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive DeclineQian Chen0Sichu Wu1Xin Li2Yi Sun3Wenqian Chen4Jiaming Lu5Wen Zhang6Jiani Liu7Zhao Qing8Zhao Qing9Zuzana Nedelska10Zuzana Nedelska11Jakub Hort12Jakub Hort13Xin Zhang14Xin Zhang15Bing Zhang16Bing Zhang17Bing Zhang18Department of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaInstitute of Brain Science, Nanjing University, Nanjing, ChinaMemory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, CzechiaInternational Clinical Research Center, St. Anne's University Hospital Brno, Brno, CzechiaMemory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, CzechiaInternational Clinical Research Center, St. Anne's University Hospital Brno, Brno, CzechiaDepartment of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, ChinaInstitute of Brain Science, Nanjing University, Nanjing, ChinaIndividuals with subjective cognitive decline (SCD) are at higher risk of incipient Alzheimer's disease (AD). Spatial navigation (SN) impairments in AD dementia and mild cognitive impairment patients have been well-documented; however, studies investigating SN deficits in SCD subjects are still lacking. This study aimed to explore whether basal forebrain (BF) and entorhinal cortex (EC) atrophy contribute to spatial disorientation in the SCD stage. In total, 31 SCD subjects and 24 normal controls were enrolled and administered cognitive scales, a 2-dimensional computerized SN test, and structural magnetic resonance imaging (MRI) scanning. We computed the differences in navigation distance errors and volumes of BF subfields, EC, and hippocampus between the SCD and control groups. The correlations between MRI volumetry and navigation distance errors were also calculated. Compared with the controls, the SCD subjects performed worse in both egocentric and allocentric navigation. The SCD group showed volume reductions in the whole BF (p < 0.05, uncorrected) and the Ch4p subfield (p < 0.05, Bonferroni corrected), but comparable EC and hippocampal volumes with the controls. In the SCD cohort, the allocentric errors were negatively correlated with total BF (r = −0.625, p < 0.001), Ch4p (r = −0.625, p < 0.001), total EC (r = −0.423, p = 0.031), and left EC volumes (r = −0.442, p = 0.024), adjusting for age, gender, years of education, total intracranial volume, and hippocampal volume. This study demonstrates that SN deficits and BF atrophy may be promising indicators for the early detection of incipient AD patients. The reduced BF volume, especially in the Ch4p subfield, may serve as a structural basis for allocentric disorientation in SCD subjects independent of hippocampal atrophy. Our findings may have further implications for the preclinical diagnosis and intervention for potential AD patients.https://www.frontiersin.org/articles/10.3389/fnagi.2021.596025/fullsubjective cognitive declinebasal forebrainentorhinal cortexspatial navigationallocentric |
| spellingShingle | Qian Chen Sichu Wu Xin Li Yi Sun Wenqian Chen Jiaming Lu Wen Zhang Jiani Liu Zhao Qing Zhao Qing Zuzana Nedelska Zuzana Nedelska Jakub Hort Jakub Hort Xin Zhang Xin Zhang Bing Zhang Bing Zhang Bing Zhang Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline Frontiers in Aging Neuroscience subjective cognitive decline basal forebrain entorhinal cortex spatial navigation allocentric |
| title | Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline |
| title_full | Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline |
| title_fullStr | Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline |
| title_full_unstemmed | Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline |
| title_short | Basal Forebrain Atrophy Is Associated With Allocentric Navigation Deficits in Subjective Cognitive Decline |
| title_sort | basal forebrain atrophy is associated with allocentric navigation deficits in subjective cognitive decline |
| topic | subjective cognitive decline basal forebrain entorhinal cortex spatial navigation allocentric |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.596025/full |
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