Electrodermal activity and heart rate variability for detection of peripheral abnormalities in type 2 diabetes: A review

Modern medicine exhibits an upward trend towards non-invasive methods for early detection of disease and long-term monitoring of patients’ health. Diabetes mellitus and its complications are a promising area for implementation of new medical diagnostic devices. One of the most serious complications...

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Main Authors: Matej Žnidarič, Dominik Škrinjar, Alen Kapel
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023-09-01
Series:Biomolecules & Biomedicine
Subjects:
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/8561
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author Matej Žnidarič
Dominik Škrinjar
Alen Kapel
author_facet Matej Žnidarič
Dominik Škrinjar
Alen Kapel
author_sort Matej Žnidarič
collection DOAJ
description Modern medicine exhibits an upward trend towards non-invasive methods for early detection of disease and long-term monitoring of patients’ health. Diabetes mellitus and its complications are a promising area for implementation of new medical diagnostic devices. One of the most serious complications of diabetes is diabetic foot ulcer. The main causes responsible for diabetic foot ulcer are ischemia caused by peripheral artery disease and diabetic neuropathy caused by polyol pathway-induced oxidative stress. Autonomic neuropathy impairs function of sweat glands, which can be measured by electrodermal activity. On the other hand, autonomic neuropathy leads to changes in heart rate variability, which is used to assess autonomic regulation of the sinoatrial node. Both methods are enough sensitive to detect pathological changes caused by autonomic neuropathy and are promising screening methods for early diagnosis of diabetic neuropathy, which could prevent the onset of diabetic ulcer.
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spelling doaj.art-be699f53d1dd4cacb2e4ce478ded0af82024-03-15T13:22:34ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-09-0123510.17305/bb.2022.8561Electrodermal activity and heart rate variability for detection of peripheral abnormalities in type 2 diabetes: A reviewMatej Žnidarič0https://orcid.org/0000-0001-5015-9085Dominik Škrinjar1https://orcid.org/0000-0002-1354-7705Alen Kapel2https://orcid.org/0000-0002-1522-9866Faculty of Medicine, University of Maribor, Maribor, Slovenia Faculty of Medicine, University of Maribor, Maribor, Slovenia Faculty of Health and Social Sciences, Slovenj Gradec, Slovenia; Alma Mater Europaea, Maribor, Slovenia; Modus Medical, Maribor, SloveniaModern medicine exhibits an upward trend towards non-invasive methods for early detection of disease and long-term monitoring of patients’ health. Diabetes mellitus and its complications are a promising area for implementation of new medical diagnostic devices. One of the most serious complications of diabetes is diabetic foot ulcer. The main causes responsible for diabetic foot ulcer are ischemia caused by peripheral artery disease and diabetic neuropathy caused by polyol pathway-induced oxidative stress. Autonomic neuropathy impairs function of sweat glands, which can be measured by electrodermal activity. On the other hand, autonomic neuropathy leads to changes in heart rate variability, which is used to assess autonomic regulation of the sinoatrial node. Both methods are enough sensitive to detect pathological changes caused by autonomic neuropathy and are promising screening methods for early diagnosis of diabetic neuropathy, which could prevent the onset of diabetic ulcer. https://www.bjbms.org/ojs/index.php/bjbms/article/view/8561Diabetes mellitusdiabetic foot ulcerautonomic neuropathyelectrodermal activityheart rate variability
spellingShingle Matej Žnidarič
Dominik Škrinjar
Alen Kapel
Electrodermal activity and heart rate variability for detection of peripheral abnormalities in type 2 diabetes: A review
Biomolecules & Biomedicine
Diabetes mellitus
diabetic foot ulcer
autonomic neuropathy
electrodermal activity
heart rate variability
title Electrodermal activity and heart rate variability for detection of peripheral abnormalities in type 2 diabetes: A review
title_full Electrodermal activity and heart rate variability for detection of peripheral abnormalities in type 2 diabetes: A review
title_fullStr Electrodermal activity and heart rate variability for detection of peripheral abnormalities in type 2 diabetes: A review
title_full_unstemmed Electrodermal activity and heart rate variability for detection of peripheral abnormalities in type 2 diabetes: A review
title_short Electrodermal activity and heart rate variability for detection of peripheral abnormalities in type 2 diabetes: A review
title_sort electrodermal activity and heart rate variability for detection of peripheral abnormalities in type 2 diabetes a review
topic Diabetes mellitus
diabetic foot ulcer
autonomic neuropathy
electrodermal activity
heart rate variability
url https://www.bjbms.org/ojs/index.php/bjbms/article/view/8561
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AT dominikskrinjar electrodermalactivityandheartratevariabilityfordetectionofperipheralabnormalitiesintype2diabetesareview
AT alenkapel electrodermalactivityandheartratevariabilityfordetectionofperipheralabnormalitiesintype2diabetesareview