Neuropsychotoxicity of Abused Drugs: Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents
Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) function to remodel the pericellular environment. We have investigated the role of the MMP/ TIMP system in methamphetamine (METH) dependence in rodents, in which the remodeling of neural circuits may be crucial. Repeated METH treatment in...
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Elsevier
2008-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319315300 |
| _version_ | 1818309626249084928 |
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| author | Hiroyuki Mizoguchi Kiyofumi Yamada Toshitaka Nabeshima |
| author_facet | Hiroyuki Mizoguchi Kiyofumi Yamada Toshitaka Nabeshima |
| author_sort | Hiroyuki Mizoguchi |
| collection | DOAJ |
| description | Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) function to remodel the pericellular environment. We have investigated the role of the MMP/ TIMP system in methamphetamine (METH) dependence in rodents, in which the remodeling of neural circuits may be crucial. Repeated METH treatment induced behavioral sensitization, which was accompanied by an increase in MMP-2/-9/ TIMP-2 activity in the brain. An antisense TIMP-2 oligonucleotide enhanced the sensitization, which was associated with a potentiation of the METH-induced release of dopamine in the nucleus accumbens (NAc). MMP-2/-9 inhibitors blocked the METH-induced behavioral sensitization and conditioned place preference (CPP), a measure of the rewarding effect of a drug, and reduced the METH-increased dopamine release in the NAc. In MMP-2– and MMP-9–deficient mice, METH-induced behavioral sensitization and CPP as well as dopamine release were attenuated. The MMP/ TIMP system may be involved in METH-induced sensitization and reward by regulating extracellular dopamine levels. Keywords:: drugs of abuse, matrix metalloproteinase, tissue inhibitor of matrix metalloproteinase, methamphetamine, dopamine |
| first_indexed | 2024-12-13T07:33:09Z |
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| id | doaj.art-be6a06f24cba41ccaa01564fb91c2969 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-13T07:33:09Z |
| publishDate | 2008-01-01 |
| publisher | Elsevier |
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| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-be6a06f24cba41ccaa01564fb91c29692022-12-21T23:55:09ZengElsevierJournal of Pharmacological Sciences1347-86132008-01-011061914Neuropsychotoxicity of Abused Drugs: Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in RodentsHiroyuki Mizoguchi0Kiyofumi Yamada1Toshitaka Nabeshima2Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan; Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science & Technology, Kanazawa University, Kanazawa 920-1192, Japan; Futuristic Environmental Simulation Center, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464-8601, JapanDepartment of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan; Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science & Technology, Kanazawa University, Kanazawa 920-1192, Japan; Corresponding author (affiliation #1). kyamada@med.nagoya-u.ac.jp Published online in J-STAGE: January 16, 2008Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan; Department of Chemical Pharmacology, Meijo University Graduate School of Pharmaceutical Sciences, Nagoya 468-8503, JapanMatrix metalloproteinases (MMPs) and their inhibitors (TIMPs) function to remodel the pericellular environment. We have investigated the role of the MMP/ TIMP system in methamphetamine (METH) dependence in rodents, in which the remodeling of neural circuits may be crucial. Repeated METH treatment induced behavioral sensitization, which was accompanied by an increase in MMP-2/-9/ TIMP-2 activity in the brain. An antisense TIMP-2 oligonucleotide enhanced the sensitization, which was associated with a potentiation of the METH-induced release of dopamine in the nucleus accumbens (NAc). MMP-2/-9 inhibitors blocked the METH-induced behavioral sensitization and conditioned place preference (CPP), a measure of the rewarding effect of a drug, and reduced the METH-increased dopamine release in the NAc. In MMP-2– and MMP-9–deficient mice, METH-induced behavioral sensitization and CPP as well as dopamine release were attenuated. The MMP/ TIMP system may be involved in METH-induced sensitization and reward by regulating extracellular dopamine levels. Keywords:: drugs of abuse, matrix metalloproteinase, tissue inhibitor of matrix metalloproteinase, methamphetamine, dopaminehttp://www.sciencedirect.com/science/article/pii/S1347861319315300 |
| spellingShingle | Hiroyuki Mizoguchi Kiyofumi Yamada Toshitaka Nabeshima Neuropsychotoxicity of Abused Drugs: Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents Journal of Pharmacological Sciences |
| title | Neuropsychotoxicity of Abused Drugs: Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents |
| title_full | Neuropsychotoxicity of Abused Drugs: Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents |
| title_fullStr | Neuropsychotoxicity of Abused Drugs: Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents |
| title_full_unstemmed | Neuropsychotoxicity of Abused Drugs: Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents |
| title_short | Neuropsychotoxicity of Abused Drugs: Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents |
| title_sort | neuropsychotoxicity of abused drugs involvement of matrix metalloproteinase 2 and 9 and tissue inhibitor of matrix metalloproteinase 2 in methamphetamine induced behavioral sensitization and reward in rodents |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319315300 |
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