KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TEs. We demonstrate that many recently emerged...

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Bibliographic Details
Main Authors: Gernot Wolf, Alberto de Iaco, Ming-An Sun, Melania Bruno, Matthew Tinkham, Don Hoang, Apratim Mitra, Sherry Ralls, Didier Trono, Todd S Macfarlan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
KRAB-ZFP
transposable elements
retrotransposons
evolution
chromatin
development
Online Access:https://elifesciences.org/articles/56337

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