Risk factors of sleep-disordered breathing in haemodialysis patients.
<h4>Background</h4>Sleep-disordered breathing (SDB) is common in patients with kidney disease; but often underdiagnosed as it is infrequently assessed in clinical practice. The objective of this study was to assess the risk factors of SDB in haemodialysis patients, and to identify useful...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0220932 |
| _version_ | 1819037093357158400 |
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| author | Ginger Chu Belinda Suthers Luke Moore Gemma M Paech Michael J Hensley Vanessa M McDonald Peter Choi |
| author_facet | Ginger Chu Belinda Suthers Luke Moore Gemma M Paech Michael J Hensley Vanessa M McDonald Peter Choi |
| author_sort | Ginger Chu |
| collection | DOAJ |
| description | <h4>Background</h4>Sleep-disordered breathing (SDB) is common in patients with kidney disease; but often underdiagnosed as it is infrequently assessed in clinical practice. The objective of this study was to assess the risk factors of SDB in haemodialysis patients, and to identify useful assessment tools to detect SDB in this population.<h4>Methods</h4>We used nocturnal oximetry, Epworth Sleepiness Scale (ESS) and STOPBANG questionnaire to screen for SDB in haemodialysis patients. Presence of SDB was defined by Oxygen desaturation index (ODI≥5/h), and further confirmed by apnoea-hypopnea index (AHI) from an in-laboratory polysomnography. Blood samples were collected prior to commencing a haemodialysis treatment.<h4>Results</h4>SDB was detected in 70% of participants (N = 107, mean age 67 years). STOPBANG revealed that 89% of participants were at risk of SDB; however, only 17% reported daytime sleepiness on the ESS. Of the participants who underwent polysomnography (n = 36), obstructive sleep apnoea was identified in 86%, and median AHI was 34.5/h. Oximetry and AHI results were positively correlated (r = 0.62, P = 0.0001), as were oximetry and STOPBANG (r = 0.48; P<0.0001), but not ESS (r = 0.19; P = 0.08). Multivariate analysis showed that neck circumference (OR: 1.20; 95% CI: 1.07-1.34; P = 0.02) and haemoglobin (OR: 0.93; 95% CI: 0.88-0.97; P = 0.003) were independently associated with the presence of SDB.<h4>Conclusion</h4>Dialysis patients with a large neck circumference and anaemia are at risk of SDB; using nocturnal oximetry is practical and reliable to screen for SDB and should be considered in routine management of dialysis patients, particularly for those who demonstrate risk factors. |
| first_indexed | 2024-12-21T08:15:56Z |
| format | Article |
| id | doaj.art-be6ca46c28ed4a52bf5526d115d4a1fa |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T08:15:56Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-be6ca46c28ed4a52bf5526d115d4a1fa2022-12-21T19:10:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01148e022093210.1371/journal.pone.0220932Risk factors of sleep-disordered breathing in haemodialysis patients.Ginger ChuBelinda SuthersLuke MooreGemma M PaechMichael J HensleyVanessa M McDonaldPeter Choi<h4>Background</h4>Sleep-disordered breathing (SDB) is common in patients with kidney disease; but often underdiagnosed as it is infrequently assessed in clinical practice. The objective of this study was to assess the risk factors of SDB in haemodialysis patients, and to identify useful assessment tools to detect SDB in this population.<h4>Methods</h4>We used nocturnal oximetry, Epworth Sleepiness Scale (ESS) and STOPBANG questionnaire to screen for SDB in haemodialysis patients. Presence of SDB was defined by Oxygen desaturation index (ODI≥5/h), and further confirmed by apnoea-hypopnea index (AHI) from an in-laboratory polysomnography. Blood samples were collected prior to commencing a haemodialysis treatment.<h4>Results</h4>SDB was detected in 70% of participants (N = 107, mean age 67 years). STOPBANG revealed that 89% of participants were at risk of SDB; however, only 17% reported daytime sleepiness on the ESS. Of the participants who underwent polysomnography (n = 36), obstructive sleep apnoea was identified in 86%, and median AHI was 34.5/h. Oximetry and AHI results were positively correlated (r = 0.62, P = 0.0001), as were oximetry and STOPBANG (r = 0.48; P<0.0001), but not ESS (r = 0.19; P = 0.08). Multivariate analysis showed that neck circumference (OR: 1.20; 95% CI: 1.07-1.34; P = 0.02) and haemoglobin (OR: 0.93; 95% CI: 0.88-0.97; P = 0.003) were independently associated with the presence of SDB.<h4>Conclusion</h4>Dialysis patients with a large neck circumference and anaemia are at risk of SDB; using nocturnal oximetry is practical and reliable to screen for SDB and should be considered in routine management of dialysis patients, particularly for those who demonstrate risk factors.https://doi.org/10.1371/journal.pone.0220932 |
| spellingShingle | Ginger Chu Belinda Suthers Luke Moore Gemma M Paech Michael J Hensley Vanessa M McDonald Peter Choi Risk factors of sleep-disordered breathing in haemodialysis patients. PLoS ONE |
| title | Risk factors of sleep-disordered breathing in haemodialysis patients. |
| title_full | Risk factors of sleep-disordered breathing in haemodialysis patients. |
| title_fullStr | Risk factors of sleep-disordered breathing in haemodialysis patients. |
| title_full_unstemmed | Risk factors of sleep-disordered breathing in haemodialysis patients. |
| title_short | Risk factors of sleep-disordered breathing in haemodialysis patients. |
| title_sort | risk factors of sleep disordered breathing in haemodialysis patients |
| url | https://doi.org/10.1371/journal.pone.0220932 |
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