State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRI
Purpose: Although efforts have been made to identify neurobiological characteristic of major depressive disorder (MDD) in recent years, trait- and state-related biological characteristics of MDD still remains unclear. Using functional magnetic resonance imaging (fMRI), the aim of this study was to e...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyg.2019.00245/full |
| _version_ | 1818173606904987648 |
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| author | Chang Cheng Chang Cheng Daifeng Dong Yali Jiang Qingsen Ming Xue Zhong Xiaoqiang Sun Ge Xiong Yidian Gao Shuqiao Yao |
| author_facet | Chang Cheng Chang Cheng Daifeng Dong Yali Jiang Qingsen Ming Xue Zhong Xiaoqiang Sun Ge Xiong Yidian Gao Shuqiao Yao |
| author_sort | Chang Cheng |
| collection | DOAJ |
| description | Purpose: Although efforts have been made to identify neurobiological characteristic of major depressive disorder (MDD) in recent years, trait- and state-related biological characteristics of MDD still remains unclear. Using functional magnetic resonance imaging (fMRI), the aim of this study was to explore whether altered spontaneous neural activities in MDD are trait- or state- related.Materials and Methods: Resting-state fMRI data were analyzed for 72 current MDD (cMDD) patients (first-episode, medication-naïve), 49 remitted MDD (rMDD) patients, and 78 age- and sex- matched healthy control (HC) subjects. The values of amplitude of low-frequency fluctuation (ALFF) were compared between groups.Results: Compared with the cMDD group, the rMDD group had increased ALFF values in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe. Besides, compared with the HC group, the cMDD group had decreased ALFF values in the left middle occipital gyrus. Further analysis explored that the mean ALFF values in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe were correlated positively with BDI scores in rMDD patients.Conclusion: Abnormal activity in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe may be state-specific in current (first-episode, medication-naïve) and remitted (medication-naïve) depression patients. Furthermore, the state-related compensatory effect was found in these brain areas. |
| first_indexed | 2024-12-11T19:31:11Z |
| format | Article |
| id | doaj.art-be6e8be394ce46dd98e1afe617047239 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-11T19:31:11Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-be6e8be394ce46dd98e1afe6170472392022-12-22T00:53:16ZengFrontiers Media S.A.Frontiers in Psychology1664-10782019-02-011010.3389/fpsyg.2019.00245423476State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRIChang Cheng0Chang Cheng1Daifeng Dong2Yali Jiang3Qingsen Ming4Xue Zhong5Xiaoqiang Sun6Ge Xiong7Yidian Gao8Shuqiao Yao9Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaPreschool Education Department, Changsha Normal University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaPurpose: Although efforts have been made to identify neurobiological characteristic of major depressive disorder (MDD) in recent years, trait- and state-related biological characteristics of MDD still remains unclear. Using functional magnetic resonance imaging (fMRI), the aim of this study was to explore whether altered spontaneous neural activities in MDD are trait- or state- related.Materials and Methods: Resting-state fMRI data were analyzed for 72 current MDD (cMDD) patients (first-episode, medication-naïve), 49 remitted MDD (rMDD) patients, and 78 age- and sex- matched healthy control (HC) subjects. The values of amplitude of low-frequency fluctuation (ALFF) were compared between groups.Results: Compared with the cMDD group, the rMDD group had increased ALFF values in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe. Besides, compared with the HC group, the cMDD group had decreased ALFF values in the left middle occipital gyrus. Further analysis explored that the mean ALFF values in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe were correlated positively with BDI scores in rMDD patients.Conclusion: Abnormal activity in the left middle occipital gyrus, left middle temporal gyrus and right cerebellum anterior lobe may be state-specific in current (first-episode, medication-naïve) and remitted (medication-naïve) depression patients. Furthermore, the state-related compensatory effect was found in these brain areas.https://www.frontiersin.org/article/10.3389/fpsyg.2019.00245/fullmajor depressive disorderremissiontrait-relatedstate-relatedresting-state fMRIamplitude of low-frequency fluctuation |
| spellingShingle | Chang Cheng Chang Cheng Daifeng Dong Yali Jiang Qingsen Ming Xue Zhong Xiaoqiang Sun Ge Xiong Yidian Gao Shuqiao Yao State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRI Frontiers in Psychology major depressive disorder remission trait-related state-related resting-state fMRI amplitude of low-frequency fluctuation |
| title | State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRI |
| title_full | State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRI |
| title_fullStr | State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRI |
| title_full_unstemmed | State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRI |
| title_short | State-Related Alterations of Spontaneous Neural Activity in Current and Remitted Depression Revealed by Resting-State fMRI |
| title_sort | state related alterations of spontaneous neural activity in current and remitted depression revealed by resting state fmri |
| topic | major depressive disorder remission trait-related state-related resting-state fMRI amplitude of low-frequency fluctuation |
| url | https://www.frontiersin.org/article/10.3389/fpsyg.2019.00245/full |
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