Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade
Abstract The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastasis. The therapeutic effects of ABL inactivation ar...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-021-00739-6 |
| _version_ | 1818646869643886592 |
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| author | Jillian Hattaway Luttman Ashley Colemon Benjamin Mayro Ann Marie Pendergast |
| author_facet | Jillian Hattaway Luttman Ashley Colemon Benjamin Mayro Ann Marie Pendergast |
| author_sort | Jillian Hattaway Luttman |
| collection | DOAJ |
| description | Abstract The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastasis. The therapeutic effects of ABL inactivation are due in part to ABL-dependent regulation of diverse cellular processes related to the epithelial to mesenchymal transition and subsequent steps in the metastatic cascade. ABL kinases target multiple signaling pathways required for promoting one or more steps in the metastatic cascade. These findings highlight the potential utility of specific ABL kinase inhibitors as a novel treatment paradigm for patients with advanced metastatic disease. Video abstract |
| first_indexed | 2024-12-17T00:53:30Z |
| format | Article |
| id | doaj.art-be71b935fea0465399abeaf2aea02bf6 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-17T00:53:30Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-be71b935fea0465399abeaf2aea02bf62022-12-21T22:09:41ZengBMCCell Communication and Signaling1478-811X2021-05-0119111610.1186/s12964-021-00739-6Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascadeJillian Hattaway Luttman0Ashley Colemon1Benjamin Mayro2Ann Marie Pendergast3Department of Pharmacology and Cancer Biology, Duke University School of MedicineDepartment of Pharmacology and Cancer Biology, Duke University School of MedicineDepartment of Pharmacology and Cancer Biology, Duke University School of MedicineDepartment of Pharmacology and Cancer Biology, Duke University School of MedicineAbstract The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that ABL inactivation impairs metastasis. The therapeutic effects of ABL inactivation are due in part to ABL-dependent regulation of diverse cellular processes related to the epithelial to mesenchymal transition and subsequent steps in the metastatic cascade. ABL kinases target multiple signaling pathways required for promoting one or more steps in the metastatic cascade. These findings highlight the potential utility of specific ABL kinase inhibitors as a novel treatment paradigm for patients with advanced metastatic disease. Video abstracthttps://doi.org/10.1186/s12964-021-00739-6ABL kinasesSignalingEMTMetastasis |
| spellingShingle | Jillian Hattaway Luttman Ashley Colemon Benjamin Mayro Ann Marie Pendergast Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade Cell Communication and Signaling ABL kinases Signaling EMT Metastasis |
| title | Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade |
| title_full | Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade |
| title_fullStr | Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade |
| title_full_unstemmed | Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade |
| title_short | Role of the ABL tyrosine kinases in the epithelial–mesenchymal transition and the metastatic cascade |
| title_sort | role of the abl tyrosine kinases in the epithelial mesenchymal transition and the metastatic cascade |
| topic | ABL kinases Signaling EMT Metastasis |
| url | https://doi.org/10.1186/s12964-021-00739-6 |
| work_keys_str_mv | AT jillianhattawayluttman roleoftheabltyrosinekinasesintheepithelialmesenchymaltransitionandthemetastaticcascade AT ashleycolemon roleoftheabltyrosinekinasesintheepithelialmesenchymaltransitionandthemetastaticcascade AT benjaminmayro roleoftheabltyrosinekinasesintheepithelialmesenchymaltransitionandthemetastaticcascade AT annmariependergast roleoftheabltyrosinekinasesintheepithelialmesenchymaltransitionandthemetastaticcascade |