Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases
Intestinal diseases like inflammatory bowel disease (IBD) and colorectal cancer originate from inflammation and disruption of mucosal barriers. Polyphenols can mitigate intestinal inflammation through antioxidant, anti‐inflammatory, and microbiome modulation effects. However, the poor solubility and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-11-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202300046 |
| _version_ | 1797542493608214528 |
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| author | Qinling Liu Yunxiang He Yan Fang Yue Wu Guidong Gong Xiao Du Junling Guo |
| author_facet | Qinling Liu Yunxiang He Yan Fang Yue Wu Guidong Gong Xiao Du Junling Guo |
| author_sort | Qinling Liu |
| collection | DOAJ |
| description | Intestinal diseases like inflammatory bowel disease (IBD) and colorectal cancer originate from inflammation and disruption of mucosal barriers. Polyphenols can mitigate intestinal inflammation through antioxidant, anti‐inflammatory, and microbiome modulation effects. However, the poor solubility and stability of polyphenols restrict therapeutic delivery. Self‐assembly provides a nanoscale platform to overcome these limitations. Polyphenol‐based nanoparticles (PNPs) are formed via coordination of polyphenols with metals like iron, copper, and zinc based on the catechol/galloyl groups. Templeted assembly with amphiphilic block copolymers can also direct polyphenol self‐assembly into nanostructures. PNPs prepared by these mild, aqueous methods exhibit enhanced stability, pH‐responsive disassembly, high cargo‐loading capacity, and targeted accumulation in inflamed intestinal tissues. PNPs can load with hydrophobic polyphenols, drugs, genes, proteins, or probiotics and demonstrate therapeutic potential in preclinical IBD, colorectal cancer, and microbiome disorder models. Ongoing challenges include augmenting prebiotic effects, multidrug encapsulation, and engineering PNPs as biotherapeutics. Future directions involve tailored polyphenol–polymer covalent assemblies and investigating PNPs interactions with enterocytes, immune cells, and microbiota. Overall, PNPs prepared by facile self‐assembly combine the bioactivities of polyphenols with advanced delivery functionality, presenting new opportunities for combination and microbiota‐based therapies for complex intestinal diseases. |
| first_indexed | 2024-03-10T13:31:20Z |
| format | Article |
| id | doaj.art-be724868a6294353af39e364d0e1c2e2 |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-03-10T13:31:20Z |
| publishDate | 2023-11-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-be724868a6294353af39e364d0e1c2e22023-11-21T07:57:43ZengWiley-VCHAdvanced NanoBiomed Research2699-93072023-11-01311n/an/a10.1002/anbr.202300046Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal DiseasesQinling Liu0Yunxiang He1Yan Fang2Yue Wu3Guidong Gong4Xiao Du5Junling Guo6Tea Refining and Innovation Key Laboratory of Sichuan Province College of Horticulture Sichuan Agricultural University Chengdu Sichuan 611130 ChinaBMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and Engineering Sichuan University Chengdu Sichuan 610065 ChinaBMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and Engineering Sichuan University Chengdu Sichuan 610065 ChinaBMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and Engineering Sichuan University Chengdu Sichuan 610065 ChinaBMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and Engineering Sichuan University Chengdu Sichuan 610065 ChinaTea Refining and Innovation Key Laboratory of Sichuan Province College of Horticulture Sichuan Agricultural University Chengdu Sichuan 611130 ChinaBMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and Engineering Sichuan University Chengdu Sichuan 610065 ChinaIntestinal diseases like inflammatory bowel disease (IBD) and colorectal cancer originate from inflammation and disruption of mucosal barriers. Polyphenols can mitigate intestinal inflammation through antioxidant, anti‐inflammatory, and microbiome modulation effects. However, the poor solubility and stability of polyphenols restrict therapeutic delivery. Self‐assembly provides a nanoscale platform to overcome these limitations. Polyphenol‐based nanoparticles (PNPs) are formed via coordination of polyphenols with metals like iron, copper, and zinc based on the catechol/galloyl groups. Templeted assembly with amphiphilic block copolymers can also direct polyphenol self‐assembly into nanostructures. PNPs prepared by these mild, aqueous methods exhibit enhanced stability, pH‐responsive disassembly, high cargo‐loading capacity, and targeted accumulation in inflamed intestinal tissues. PNPs can load with hydrophobic polyphenols, drugs, genes, proteins, or probiotics and demonstrate therapeutic potential in preclinical IBD, colorectal cancer, and microbiome disorder models. Ongoing challenges include augmenting prebiotic effects, multidrug encapsulation, and engineering PNPs as biotherapeutics. Future directions involve tailored polyphenol–polymer covalent assemblies and investigating PNPs interactions with enterocytes, immune cells, and microbiota. Overall, PNPs prepared by facile self‐assembly combine the bioactivities of polyphenols with advanced delivery functionality, presenting new opportunities for combination and microbiota‐based therapies for complex intestinal diseases.https://doi.org/10.1002/anbr.202300046anti-inflammatorydrug deliveryintestinal disease treatmentsnanoparticlespolyphenols |
| spellingShingle | Qinling Liu Yunxiang He Yan Fang Yue Wu Guidong Gong Xiao Du Junling Guo Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases Advanced NanoBiomed Research anti-inflammatory drug delivery intestinal disease treatments nanoparticles polyphenols |
| title | Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases |
| title_full | Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases |
| title_fullStr | Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases |
| title_full_unstemmed | Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases |
| title_short | Emerging Self‐Assembled Nanoparticles Constructed from Natural Polyphenols for Intestinal Diseases |
| title_sort | emerging self assembled nanoparticles constructed from natural polyphenols for intestinal diseases |
| topic | anti-inflammatory drug delivery intestinal disease treatments nanoparticles polyphenols |
| url | https://doi.org/10.1002/anbr.202300046 |
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