Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers
Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative stress, damage, and cell death, playing an important role in neuroplasticity a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/11/539 |
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| author | Ane Larrea Ane Elexpe Eguzkiñe Díez-Martín María Torrecilla Egoitz Astigarraga Gabriel Barreda-Gómez |
| author_facet | Ane Larrea Ane Elexpe Eguzkiñe Díez-Martín María Torrecilla Egoitz Astigarraga Gabriel Barreda-Gómez |
| author_sort | Ane Larrea |
| collection | DOAJ |
| description | Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative stress, damage, and cell death, playing an important role in neuroplasticity and motor dysfunction by affecting the neuronal connection responsible for motor control. The diagnosis of this pathology is performed using neuroimaging techniques and molecular diagnostics based on identifying and measuring signaling molecules or specific markers. In parallel, new therapeutic targets are being investigated via the use of bionanomaterials and electrostimulation to modulate the neuroinflammatory response. These novel diagnostic and therapeutic strategies have the potential to facilitate the development of anticipatory patterns and deliver the most beneficial treatment to improve patients’ quality of life and directly impact their motor skills. However, important challenges remain to be solved. Hence, the goal of this study was to review the implication of neuroinflammation in the evolution of motor function in stroke and trauma patients, with a particular focus on novel methods and potential biomarkers to aid clinicians in diagnosis, treatment, and therapy. A specific analysis of the strengths, weaknesses, threats, and opportunities was conducted, highlighting the key challenges to be faced in the coming years. |
| first_indexed | 2024-03-09T16:56:04Z |
| format | Article |
| id | doaj.art-be7299edb56c4e1ebb652786e8d62a6f |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T16:56:04Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-be7299edb56c4e1ebb652786e8d62a6f2023-11-24T14:36:03ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-10-0145118552858510.3390/cimb45110539Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential BiomarkersAne Larrea0Ane Elexpe1Eguzkiñe Díez-Martín2María Torrecilla3Egoitz Astigarraga4Gabriel Barreda-Gómez5Research and Development Division, IMG Pharma Biotech, 48170 Zamudio, SpainResearch and Development Division, IMG Pharma Biotech, 48170 Zamudio, SpainResearch and Development Division, IMG Pharma Biotech, 48170 Zamudio, SpainDepartment of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, SpainResearch and Development Division, IMG Pharma Biotech, 48170 Zamudio, SpainResearch and Development Division, IMG Pharma Biotech, 48170 Zamudio, SpainNeuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. Neuroinflammation involves oxidative stress, damage, and cell death, playing an important role in neuroplasticity and motor dysfunction by affecting the neuronal connection responsible for motor control. The diagnosis of this pathology is performed using neuroimaging techniques and molecular diagnostics based on identifying and measuring signaling molecules or specific markers. In parallel, new therapeutic targets are being investigated via the use of bionanomaterials and electrostimulation to modulate the neuroinflammatory response. These novel diagnostic and therapeutic strategies have the potential to facilitate the development of anticipatory patterns and deliver the most beneficial treatment to improve patients’ quality of life and directly impact their motor skills. However, important challenges remain to be solved. Hence, the goal of this study was to review the implication of neuroinflammation in the evolution of motor function in stroke and trauma patients, with a particular focus on novel methods and potential biomarkers to aid clinicians in diagnosis, treatment, and therapy. A specific analysis of the strengths, weaknesses, threats, and opportunities was conducted, highlighting the key challenges to be faced in the coming years.https://www.mdpi.com/1467-3045/45/11/539neuroinflammationstroketraumatic injurybiomarkerstherapy |
| spellingShingle | Ane Larrea Ane Elexpe Eguzkiñe Díez-Martín María Torrecilla Egoitz Astigarraga Gabriel Barreda-Gómez Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers Current Issues in Molecular Biology neuroinflammation stroke traumatic injury biomarkers therapy |
| title | Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers |
| title_full | Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers |
| title_fullStr | Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers |
| title_full_unstemmed | Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers |
| title_short | Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers |
| title_sort | neuroinflammation in the evolution of motor function in stroke and trauma patients treatment and potential biomarkers |
| topic | neuroinflammation stroke traumatic injury biomarkers therapy |
| url | https://www.mdpi.com/1467-3045/45/11/539 |
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