Comparing the Effect of Atypical and Conventional Antipsychotics on Lipid Profile
Background: Patients with schizophrenia receiving antipsychotic drugs are highly at risk of metabolic disorders such as weight gain, dyslipidemia, and insulin resistance. This study was designed to compare the effect of atypical and conventional antipsychotics on lipid profile. Methods: 128 patient...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2015-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/4235 |
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| author | Hamidreza Roohafza Azam Khani Hamid Afshar Safoura Yazdekhasti Jafar Golshahi |
| author_facet | Hamidreza Roohafza Azam Khani Hamid Afshar Safoura Yazdekhasti Jafar Golshahi |
| author_sort | Hamidreza Roohafza |
| collection | DOAJ |
| description | Background: Patients with schizophrenia receiving antipsychotic drugs are highly at risk of metabolic disorders such as weight gain, dyslipidemia, and insulin resistance. This study was designed to compare the effect of atypical and conventional antipsychotics on lipid profile.
Methods: 128 patients with schizophrenia were divided in two groups. One of the groups received one type of atypical antipsychotic drugs while the other got one type of conventional ones. None of the groups had used any other antipsychotic drugs during the past year. Demographic data and food frequency questionnaire were completed by each participant. Serum triglyceride, total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterols, and apolipoprotein A and B (Apo A and B) were recorded. Student’s t test was used for statistical analysis.
Findings: The two groups were similar in age, gender, duration of illness, period of drug consumption, and age at onset of illness. Patients in the atypical group used clozapine and risperidone (46.9%) more than olanzapine; while in the conventional group, 81.3% of patients used phenothiazines. Our data showed a significantly higher mean in TC (P = 0.01), LDL (P = 0.03), and Apo B (P = 0.01) in conventional group.
Conclusion: In patients with schizophrenia, lipid profile was higher in both atypical and conventional antipsychotic users, especially in conventional drug users. |
| first_indexed | 2024-03-12T09:19:25Z |
| format | Article |
| id | doaj.art-be72d170bec649ddb62e16b143ff74a6 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:19:25Z |
| publishDate | 2015-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-be72d170bec649ddb62e16b143ff74a62023-09-02T14:39:34ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2015-03-0132319239424001783Comparing the Effect of Atypical and Conventional Antipsychotics on Lipid ProfileHamidreza Roohafza0Azam Khani1Hamid Afshar2Safoura Yazdekhasti3Jafar Golshahi4Assistant Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranResearch Assistant, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, IranCardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranBackground: Patients with schizophrenia receiving antipsychotic drugs are highly at risk of metabolic disorders such as weight gain, dyslipidemia, and insulin resistance. This study was designed to compare the effect of atypical and conventional antipsychotics on lipid profile. Methods: 128 patients with schizophrenia were divided in two groups. One of the groups received one type of atypical antipsychotic drugs while the other got one type of conventional ones. None of the groups had used any other antipsychotic drugs during the past year. Demographic data and food frequency questionnaire were completed by each participant. Serum triglyceride, total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterols, and apolipoprotein A and B (Apo A and B) were recorded. Student’s t test was used for statistical analysis. Findings: The two groups were similar in age, gender, duration of illness, period of drug consumption, and age at onset of illness. Patients in the atypical group used clozapine and risperidone (46.9%) more than olanzapine; while in the conventional group, 81.3% of patients used phenothiazines. Our data showed a significantly higher mean in TC (P = 0.01), LDL (P = 0.03), and Apo B (P = 0.01) in conventional group. Conclusion: In patients with schizophrenia, lipid profile was higher in both atypical and conventional antipsychotic users, especially in conventional drug users.http://jims.mui.ac.ir/index.php/jims/article/view/4235آنتی‌سایكوتیك آتیپیك؛ آنتی‌سایكوتیك سنتی؛ سطح چربی خون |
| spellingShingle | Hamidreza Roohafza Azam Khani Hamid Afshar Safoura Yazdekhasti Jafar Golshahi Comparing the Effect of Atypical and Conventional Antipsychotics on Lipid Profile مجله دانشکده پزشکی اصفهان آنتی‌سایكوتیك آتیپیك؛ آنتی‌سایكوتیك سنتی؛ سطح چربی خون |
| title | Comparing the Effect of Atypical and Conventional Antipsychotics on Lipid Profile |
| title_full | Comparing the Effect of Atypical and Conventional Antipsychotics on Lipid Profile |
| title_fullStr | Comparing the Effect of Atypical and Conventional Antipsychotics on Lipid Profile |
| title_full_unstemmed | Comparing the Effect of Atypical and Conventional Antipsychotics on Lipid Profile |
| title_short | Comparing the Effect of Atypical and Conventional Antipsychotics on Lipid Profile |
| title_sort | comparing the effect of atypical and conventional antipsychotics on lipid profile |
| topic | آنتی‌سایكوتیك آتیپیك؛ آنتی‌سایكوتیك سنتی؛ سطح چربی خون |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/4235 |
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