Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved]
Constitutive activating mutations in KIT and platelet-derived growth factor receptor α (PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in can...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-09-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-1689/v1 |
| _version_ | 1828837128044281856 |
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| author | Florence Duffaud Axel Le Cesne |
| author_facet | Florence Duffaud Axel Le Cesne |
| author_sort | Florence Duffaud |
| collection | DOAJ |
| description | Constitutive activating mutations in KIT and platelet-derived growth factor receptor α (PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized and metastatic GISTs. |
| first_indexed | 2024-12-12T18:35:50Z |
| format | Article |
| id | doaj.art-be730a110d4b4989a7ef3b18ba1c8e23 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-12T18:35:50Z |
| publishDate | 2017-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-be730a110d4b4989a7ef3b18ba1c8e232022-12-22T00:15:48ZengF1000 Research LtdF1000Research2046-14022017-09-01610.12688/f1000research.11118.111994Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved]Florence Duffaud0Axel Le Cesne1Service d’Oncologie Médicale, CHU La Timone, Marseille, FranceDépartement d’Oncologie Médicale, Gustave Roussy Institut, Villejuif, FranceConstitutive activating mutations in KIT and platelet-derived growth factor receptor α (PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized and metastatic GISTs.https://f1000research.com/articles/6-1689/v1Cancer TherapeuticsGastrointestinal Cancers |
| spellingShingle | Florence Duffaud Axel Le Cesne Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved] F1000Research Cancer Therapeutics Gastrointestinal Cancers |
| title | Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved] |
| title_full | Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved] |
| title_fullStr | Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved] |
| title_full_unstemmed | Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved] |
| title_short | Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved] |
| title_sort | recent advances in managing gastrointestinal stromal tumor version 1 referees 2 approved |
| topic | Cancer Therapeutics Gastrointestinal Cancers |
| url | https://f1000research.com/articles/6-1689/v1 |
| work_keys_str_mv | AT florenceduffaud recentadvancesinmanaginggastrointestinalstromaltumorversion1referees2approved AT axellecesne recentadvancesinmanaginggastrointestinalstromaltumorversion1referees2approved |