Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury
Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regenerati...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Stem Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213671115003495 |
| _version_ | 1818675512125423616 |
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| author | Soya Kawabata Morito Takano Yuko Numasawa-Kuroiwa Go Itakura Yoshiomi Kobayashi Yuichiro Nishiyama Keiko Sugai Soraya Nishimura Hiroki Iwai Miho Isoda Shinsuke Shibata Jun Kohyama Akio Iwanami Yoshiaki Toyama Morio Matsumoto Masaya Nakamura Hideyuki Okano |
| author_facet | Soya Kawabata Morito Takano Yuko Numasawa-Kuroiwa Go Itakura Yoshiomi Kobayashi Yuichiro Nishiyama Keiko Sugai Soraya Nishimura Hiroki Iwai Miho Isoda Shinsuke Shibata Jun Kohyama Akio Iwanami Yoshiaki Toyama Morio Matsumoto Masaya Nakamura Hideyuki Okano |
| author_sort | Soya Kawabata |
| collection | DOAJ |
| description | Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-induced pluripotent stem cell-derived oligodendrocyte precursor cell-enriched neural stem/progenitor cells and report the benefits of transplanting these cells in a spinal cord injury (SCI) model. We describe how this approach contributes to the robust remyelination of demyelinated axons and facilitates functional recovery after SCI. |
| first_indexed | 2024-12-17T08:28:45Z |
| format | Article |
| id | doaj.art-be73a51b191f4beaadfeb4d25fe9762f |
| institution | Directory Open Access Journal |
| issn | 2213-6711 |
| language | English |
| last_indexed | 2024-12-17T08:28:45Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Reports |
| spelling | doaj.art-be73a51b191f4beaadfeb4d25fe9762f2022-12-21T21:56:41ZengElsevierStem Cell Reports2213-67112016-01-01611810.1016/j.stemcr.2015.11.013Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord InjurySoya Kawabata0Morito Takano1Yuko Numasawa-Kuroiwa2Go Itakura3Yoshiomi Kobayashi4Yuichiro Nishiyama5Keiko Sugai6Soraya Nishimura7Hiroki Iwai8Miho Isoda9Shinsuke Shibata10Jun Kohyama11Akio Iwanami12Yoshiaki Toyama13Morio Matsumoto14Masaya Nakamura15Hideyuki Okano16Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanMurine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-induced pluripotent stem cell-derived oligodendrocyte precursor cell-enriched neural stem/progenitor cells and report the benefits of transplanting these cells in a spinal cord injury (SCI) model. We describe how this approach contributes to the robust remyelination of demyelinated axons and facilitates functional recovery after SCI.http://www.sciencedirect.com/science/article/pii/S2213671115003495 |
| spellingShingle | Soya Kawabata Morito Takano Yuko Numasawa-Kuroiwa Go Itakura Yoshiomi Kobayashi Yuichiro Nishiyama Keiko Sugai Soraya Nishimura Hiroki Iwai Miho Isoda Shinsuke Shibata Jun Kohyama Akio Iwanami Yoshiaki Toyama Morio Matsumoto Masaya Nakamura Hideyuki Okano Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury Stem Cell Reports |
| title | Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury |
| title_full | Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury |
| title_fullStr | Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury |
| title_full_unstemmed | Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury |
| title_short | Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury |
| title_sort | grafted human ips cell derived oligodendrocyte precursor cells contribute to robust remyelination of demyelinated axons after spinal cord injury |
| url | http://www.sciencedirect.com/science/article/pii/S2213671115003495 |
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