Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population
In addition to its role in bone health, vitamin D (VitD) has been implicated in several pathological conditions. Specifically, VitD deficiency has been linked to an increased risk of dyslipidemia. Atherogenic dyslipidemia is characterized by increased low-density lipoprotein-cholesterol (LDL-C) and...
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MDPI AG
2022-03-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/9/4/102 |
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| author | Hana M. A. Fakhoury Said El Shamieh Amru Rifai Hani Tamim Rajaa Fakhoury |
| author_facet | Hana M. A. Fakhoury Said El Shamieh Amru Rifai Hani Tamim Rajaa Fakhoury |
| author_sort | Hana M. A. Fakhoury |
| collection | DOAJ |
| description | In addition to its role in bone health, vitamin D (VitD) has been implicated in several pathological conditions. Specifically, VitD deficiency has been linked to an increased risk of dyslipidemia. Atherogenic dyslipidemia is characterized by increased low-density lipoprotein-cholesterol (LDL-C) and decreased high-density lipoprotein-cholesterol (HDL-C). In this study, we examined the association of six single nucleotide polymorphisms (SNPs) in VitD-related genes with VitD and lipid levels, in a cohort of 460 Lebanese participants free from chronic diseases. Our results showed no association of the examined SNPs with VitD concentrations. However, the presence of the minor allele in rs10741657G>A of <i>CYP2R1</i> was associated with increased levels in LDL-C (β = 4.95, <i>p</i> = 0.04)] and decreased levels in HDL-C (β = −1.76, <i>p</i> = 0.007)]. Interestingly, rs10741657G>A interacted with gender to increase LDL-C levels in females (β = 6.73 and <i>p</i> = 0.03) and decrease HDL-C levels in males HDL-C (β = −1.09, <i>p</i> = 0.009). In conclusion, our results suggest that rs10741657 G>A in <i>CYP2R1</i> is associated with circulating LDL-C and HDL-C levels in a Lebanese cohort. Although this association was gender-specific, where rs10741657G>A was associated with increased LDL in females and decreased HDL in males, the presence of the minor allele A was associated with increased cardiovascular risk in both genders. These findings need to be validated in a larger population. Further investigations are warranted to elucidate the molecular mechanism of VitD polymorphism and dyslipidemia. |
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| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-09T10:33:25Z |
| publishDate | 2022-03-01 |
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| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-be74482508b240efa2bb2df83bbec2f32023-12-01T21:06:10ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252022-03-019410210.3390/jcdd9040102Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean PopulationHana M. A. Fakhoury0Said El Shamieh1Amru Rifai2Hani Tamim3Rajaa Fakhoury4Department of Biochemistry and Molecular Biology, College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi ArabiaDepartment of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut 11-5020, LebanonDepartment of Biochemistry and Molecular Biology, College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi ArabiaDepartment of Biochemistry and Molecular Biology, College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi ArabiaDepartment of Biochemistry and Molecular Biology, College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi ArabiaIn addition to its role in bone health, vitamin D (VitD) has been implicated in several pathological conditions. Specifically, VitD deficiency has been linked to an increased risk of dyslipidemia. Atherogenic dyslipidemia is characterized by increased low-density lipoprotein-cholesterol (LDL-C) and decreased high-density lipoprotein-cholesterol (HDL-C). In this study, we examined the association of six single nucleotide polymorphisms (SNPs) in VitD-related genes with VitD and lipid levels, in a cohort of 460 Lebanese participants free from chronic diseases. Our results showed no association of the examined SNPs with VitD concentrations. However, the presence of the minor allele in rs10741657G>A of <i>CYP2R1</i> was associated with increased levels in LDL-C (β = 4.95, <i>p</i> = 0.04)] and decreased levels in HDL-C (β = −1.76, <i>p</i> = 0.007)]. Interestingly, rs10741657G>A interacted with gender to increase LDL-C levels in females (β = 6.73 and <i>p</i> = 0.03) and decrease HDL-C levels in males HDL-C (β = −1.09, <i>p</i> = 0.009). In conclusion, our results suggest that rs10741657 G>A in <i>CYP2R1</i> is associated with circulating LDL-C and HDL-C levels in a Lebanese cohort. Although this association was gender-specific, where rs10741657G>A was associated with increased LDL in females and decreased HDL in males, the presence of the minor allele A was associated with increased cardiovascular risk in both genders. These findings need to be validated in a larger population. Further investigations are warranted to elucidate the molecular mechanism of VitD polymorphism and dyslipidemia.https://www.mdpi.com/2308-3425/9/4/102vitamin DCYP2R1rs10741657LDL cholesterolHDL cholesterolsingle nucleotide polymorphisms |
| spellingShingle | Hana M. A. Fakhoury Said El Shamieh Amru Rifai Hani Tamim Rajaa Fakhoury Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population Journal of Cardiovascular Development and Disease vitamin D CYP2R1 rs10741657 LDL cholesterol HDL cholesterol single nucleotide polymorphisms |
| title | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
| title_full | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
| title_fullStr | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
| title_full_unstemmed | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
| title_short | Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population |
| title_sort | vitamin d related gene polymorphisms and cholesterol levels in a mediterranean population |
| topic | vitamin D CYP2R1 rs10741657 LDL cholesterol HDL cholesterol single nucleotide polymorphisms |
| url | https://www.mdpi.com/2308-3425/9/4/102 |
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