Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization
With continued advances in cancer research, the crucial role of the tumor microenvironment (TME) in regulating tumor progression and influencing immunotherapy outcomes has been realized over the years. A series of studies devoted to enhancing the response to immunotherapies through exploring efficie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.969723/full |
| _version_ | 1818481581554139136 |
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| author | Yuting Li Honghong Fan Junli Ding Junying Xu Chaoying Liu Huiyu Wang |
| author_facet | Yuting Li Honghong Fan Junli Ding Junying Xu Chaoying Liu Huiyu Wang |
| author_sort | Yuting Li |
| collection | DOAJ |
| description | With continued advances in cancer research, the crucial role of the tumor microenvironment (TME) in regulating tumor progression and influencing immunotherapy outcomes has been realized over the years. A series of studies devoted to enhancing the response to immunotherapies through exploring efficient predictive biomarkers and new combination approaches. The microfluidic technology not only promoted the development of multi-omics analyses but also enabled the recapitulation of TME in vitro microfluidic system, which made these devices attractive across studies for optimization of immunotherapy. Here, we reviewed the application of microfluidic systems in modeling TME and the potential of these devices in predicting and monitoring immunotherapy effects. |
| first_indexed | 2024-12-10T11:36:52Z |
| format | Article |
| id | doaj.art-be75755820564c7fa48cdc871fe6bebb |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T11:36:52Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-be75755820564c7fa48cdc871fe6bebb2022-12-22T01:50:24ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-09-011310.3389/fgene.2022.969723969723Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimizationYuting LiHonghong FanJunli DingJunying XuChaoying LiuHuiyu WangWith continued advances in cancer research, the crucial role of the tumor microenvironment (TME) in regulating tumor progression and influencing immunotherapy outcomes has been realized over the years. A series of studies devoted to enhancing the response to immunotherapies through exploring efficient predictive biomarkers and new combination approaches. The microfluidic technology not only promoted the development of multi-omics analyses but also enabled the recapitulation of TME in vitro microfluidic system, which made these devices attractive across studies for optimization of immunotherapy. Here, we reviewed the application of microfluidic systems in modeling TME and the potential of these devices in predicting and monitoring immunotherapy effects.https://www.frontiersin.org/articles/10.3389/fgene.2022.969723/fullmicrofluidicsmicrofluidic devicesTMEtumor immunotherapymulti-omic analyses |
| spellingShingle | Yuting Li Honghong Fan Junli Ding Junying Xu Chaoying Liu Huiyu Wang Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization Frontiers in Genetics microfluidics microfluidic devices TME tumor immunotherapy multi-omic analyses |
| title | Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization |
| title_full | Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization |
| title_fullStr | Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization |
| title_full_unstemmed | Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization |
| title_short | Microfluidic devices: The application in TME modeling and the potential in immunotherapy optimization |
| title_sort | microfluidic devices the application in tme modeling and the potential in immunotherapy optimization |
| topic | microfluidics microfluidic devices TME tumor immunotherapy multi-omic analyses |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.969723/full |
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