Republication of “Gelatinous Transformation of Bone Marrow in the Calcaneus, Diagnosed by Open Bone Biopsy in a Patient With Anorexia Nervosa: A Case Report”
Gelatinous transformation of bone marrow (GTBM) is a complication of various diseases, one of which is anorexia nervosa (AN). We describe a rare case of a 20-year-old man who presented to our clinic with a 3-month history of heel pain without trauma. At presentation, he was noted to have a low body...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-08-01
|
| Series: | Foot & Ankle Orthopaedics |
| Online Access: | https://doi.org/10.1177/24730114231193415 |
| _version_ | 1797741014509682688 |
|---|---|
| author | Ichiro Tonogai MD, PhD Daiki Nakajima MD Ryo Miyagi MD Koichi Sairyo MD, PhD |
| author_facet | Ichiro Tonogai MD, PhD Daiki Nakajima MD Ryo Miyagi MD Koichi Sairyo MD, PhD |
| author_sort | Ichiro Tonogai MD, PhD |
| collection | DOAJ |
| description | Gelatinous transformation of bone marrow (GTBM) is a complication of various diseases, one of which is anorexia nervosa (AN). We describe a rare case of a 20-year-old man who presented to our clinic with a 3-month history of heel pain without trauma. At presentation, he was noted to have a low body mass index (BMI) of 16.2 kg/m 2 and pancytopenia. On magnetic resonance imaging, the left calcaneus showed low intensity on T1-weighted and high intensity on T2-weighted images. Open biopsy was done because we suspected that the lesion was either a lymphoproliferative tumor or a trabecular-type bone metastatic tumor. However, tissue histology of bone samples showed atrophy of fat cells with deposition of gelatinous material and a decreased hematopoietic cell population. Therefore, we made a diagnosis of GTBM, most likely caused by AN. We started treatment with nutritional support, and 6 months later, the hematological parameters returned to normal and BMI improved to 19.4 kg/m 2 . He was able to return to work and had no left heel pain. This case indicates that foot and ankle surgeons need to be aware of this rare pathology, although it might be difficult to diagnose without biopsy. To our knowledge, very few descriptions of GTBM in the calcaneus have been reported to date. |
| first_indexed | 2024-03-12T14:20:46Z |
| format | Article |
| id | doaj.art-be783b41d1994611b2fa205ec03853c2 |
| institution | Directory Open Access Journal |
| issn | 2473-0114 |
| language | English |
| last_indexed | 2024-03-12T14:20:46Z |
| publishDate | 2023-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Foot & Ankle Orthopaedics |
| spelling | doaj.art-be783b41d1994611b2fa205ec03853c22023-08-19T09:11:15ZengSAGE PublishingFoot & Ankle Orthopaedics2473-01142023-08-01810.1177/24730114231193415Republication of “Gelatinous Transformation of Bone Marrow in the Calcaneus, Diagnosed by Open Bone Biopsy in a Patient With Anorexia Nervosa: A Case Report”Ichiro Tonogai MD, PhD0Daiki Nakajima MD1Ryo Miyagi MD2Koichi Sairyo MD, PhD3Department of Orthopedics, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, JapanDepartment of Orthopedics, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, JapanDepartment of Orthopedics, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, JapanDepartment of Orthopedics, Institute of Biomedical Science, Tokushima University Graduate School, Tokushima, JapanGelatinous transformation of bone marrow (GTBM) is a complication of various diseases, one of which is anorexia nervosa (AN). We describe a rare case of a 20-year-old man who presented to our clinic with a 3-month history of heel pain without trauma. At presentation, he was noted to have a low body mass index (BMI) of 16.2 kg/m 2 and pancytopenia. On magnetic resonance imaging, the left calcaneus showed low intensity on T1-weighted and high intensity on T2-weighted images. Open biopsy was done because we suspected that the lesion was either a lymphoproliferative tumor or a trabecular-type bone metastatic tumor. However, tissue histology of bone samples showed atrophy of fat cells with deposition of gelatinous material and a decreased hematopoietic cell population. Therefore, we made a diagnosis of GTBM, most likely caused by AN. We started treatment with nutritional support, and 6 months later, the hematological parameters returned to normal and BMI improved to 19.4 kg/m 2 . He was able to return to work and had no left heel pain. This case indicates that foot and ankle surgeons need to be aware of this rare pathology, although it might be difficult to diagnose without biopsy. To our knowledge, very few descriptions of GTBM in the calcaneus have been reported to date.https://doi.org/10.1177/24730114231193415 |
| spellingShingle | Ichiro Tonogai MD, PhD Daiki Nakajima MD Ryo Miyagi MD Koichi Sairyo MD, PhD Republication of “Gelatinous Transformation of Bone Marrow in the Calcaneus, Diagnosed by Open Bone Biopsy in a Patient With Anorexia Nervosa: A Case Report” Foot & Ankle Orthopaedics |
| title | Republication of “Gelatinous Transformation of Bone Marrow in the Calcaneus, Diagnosed by Open Bone Biopsy in a Patient With Anorexia Nervosa: A Case Report” |
| title_full | Republication of “Gelatinous Transformation of Bone Marrow in the Calcaneus, Diagnosed by Open Bone Biopsy in a Patient With Anorexia Nervosa: A Case Report” |
| title_fullStr | Republication of “Gelatinous Transformation of Bone Marrow in the Calcaneus, Diagnosed by Open Bone Biopsy in a Patient With Anorexia Nervosa: A Case Report” |
| title_full_unstemmed | Republication of “Gelatinous Transformation of Bone Marrow in the Calcaneus, Diagnosed by Open Bone Biopsy in a Patient With Anorexia Nervosa: A Case Report” |
| title_short | Republication of “Gelatinous Transformation of Bone Marrow in the Calcaneus, Diagnosed by Open Bone Biopsy in a Patient With Anorexia Nervosa: A Case Report” |
| title_sort | republication of gelatinous transformation of bone marrow in the calcaneus diagnosed by open bone biopsy in a patient with anorexia nervosa a case report |
| url | https://doi.org/10.1177/24730114231193415 |
| work_keys_str_mv | AT ichirotonogaimdphd republicationofgelatinoustransformationofbonemarrowinthecalcaneusdiagnosedbyopenbonebiopsyinapatientwithanorexianervosaacasereport AT daikinakajimamd republicationofgelatinoustransformationofbonemarrowinthecalcaneusdiagnosedbyopenbonebiopsyinapatientwithanorexianervosaacasereport AT ryomiyagimd republicationofgelatinoustransformationofbonemarrowinthecalcaneusdiagnosedbyopenbonebiopsyinapatientwithanorexianervosaacasereport AT koichisairyomdphd republicationofgelatinoustransformationofbonemarrowinthecalcaneusdiagnosedbyopenbonebiopsyinapatientwithanorexianervosaacasereport |