Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion
Objective: To determine the prevalence and risk factors for positive surgical margin after LEEP in patients with high grade squamous intraepithelial lesion (HSIL). Material and Methods: Medical records of all women (n = 575) who underwent LEEP and histopathological diagnosed HSIL be...
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| Format: | Article |
| Language: | English |
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The Royal Thai College of Obstetricians and Gynaecologists
2015-12-01
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| Series: | Thai Journal of Obstetrics and Gynaecology |
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| Online Access: | https://tci-thaijo.org/index.php/tjog/article/view/23049/107847 |
| _version_ | 1811284450264219648 |
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| author | Palaporn Kanjanasirirut Kamol Pataradool Sumonmal Manusirivithaya Chadakarn Phaloprakarn Chutima Chavanisakun |
| author_facet | Palaporn Kanjanasirirut Kamol Pataradool Sumonmal Manusirivithaya Chadakarn Phaloprakarn Chutima Chavanisakun |
| author_sort | Palaporn Kanjanasirirut |
| collection | DOAJ |
| description | Objective: To determine the prevalence and risk factors for positive surgical margin after LEEP in patients with high grade squamous intraepithelial lesion (HSIL). Material and Methods: Medical records of all women (n = 575) who underwent LEEP and histopathological diagnosed HSIL between January 2008 and December 2012 in our institution were reviewed. The margins of surgical specimens were re-evaluated by a pathologist. Clinical data and status of surgical margin were recorded. The prevalence and risk factors for positive surgical margin were analyzed. Results: Complete data of 547 women with HSIL who underwent LEEP were obtained. Mean age of the women was 41.8 ± 12.5 years (ranging from 17 to 75 years). The majority of them were multiparous (n = 405 or 74.1%) and premenopause (n = 464 or 84.8%). Positive LEEP surgical margin was found in 167 cases (30.5 %). In multivariable analysis, multiparity and glandular involvement were two independent risk factors for positive LEEP surgical margin; adjusted relative risk of 8.10 (95% confidence interval, 3.82-17.20) and 14.10 (95% confidence interval, 8.34-23.83), respectively.Conclusions: The prevalence of positive margin in women with HSIL who underwent LEEP was 30.5%. Multiparity and glandular involvements were significant factors associated with the margin involvement. |
| first_indexed | 2024-04-13T02:28:47Z |
| format | Article |
| id | doaj.art-be7a221fad4f4a82a30ce474d2770c98 |
| institution | Directory Open Access Journal |
| issn | 0857-6084 0857-6084 |
| language | English |
| last_indexed | 2024-04-13T02:28:47Z |
| publishDate | 2015-12-01 |
| publisher | The Royal Thai College of Obstetricians and Gynaecologists |
| record_format | Article |
| series | Thai Journal of Obstetrics and Gynaecology |
| spelling | doaj.art-be7a221fad4f4a82a30ce474d2770c982022-12-22T03:06:40ZengThe Royal Thai College of Obstetricians and GynaecologistsThai Journal of Obstetrics and Gynaecology0857-60840857-60842015-12-01234240245https://doi.org/10.14456/tjog.2015.23Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial LesionPalaporn Kanjanasirirut0Kamol Pataradool1Sumonmal Manusirivithaya2Chadakarn Phaloprakarn3Chutima Chavanisakun4Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, ThailandDepartment of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, ThailandDepartment of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, ThailandDepartment of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, ThailandDepartment of Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, ThailandObjective: To determine the prevalence and risk factors for positive surgical margin after LEEP in patients with high grade squamous intraepithelial lesion (HSIL). Material and Methods: Medical records of all women (n = 575) who underwent LEEP and histopathological diagnosed HSIL between January 2008 and December 2012 in our institution were reviewed. The margins of surgical specimens were re-evaluated by a pathologist. Clinical data and status of surgical margin were recorded. The prevalence and risk factors for positive surgical margin were analyzed. Results: Complete data of 547 women with HSIL who underwent LEEP were obtained. Mean age of the women was 41.8 ± 12.5 years (ranging from 17 to 75 years). The majority of them were multiparous (n = 405 or 74.1%) and premenopause (n = 464 or 84.8%). Positive LEEP surgical margin was found in 167 cases (30.5 %). In multivariable analysis, multiparity and glandular involvement were two independent risk factors for positive LEEP surgical margin; adjusted relative risk of 8.10 (95% confidence interval, 3.82-17.20) and 14.10 (95% confidence interval, 8.34-23.83), respectively.Conclusions: The prevalence of positive margin in women with HSIL who underwent LEEP was 30.5%. Multiparity and glandular involvements were significant factors associated with the margin involvement.https://tci-thaijo.org/index.php/tjog/article/view/23049/107847HSILpositive marginLEEP |
| spellingShingle | Palaporn Kanjanasirirut Kamol Pataradool Sumonmal Manusirivithaya Chadakarn Phaloprakarn Chutima Chavanisakun Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion Thai Journal of Obstetrics and Gynaecology HSIL positive margin LEEP |
| title | Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion |
| title_full | Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion |
| title_fullStr | Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion |
| title_full_unstemmed | Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion |
| title_short | Prevalence and Risk Factors for Positive Surgical Margin after Loop Electrosurgical Excision Procedure (LEEP) in Patients with High Grade Squamous Intraepithelial Lesion |
| title_sort | prevalence and risk factors for positive surgical margin after loop electrosurgical excision procedure leep in patients with high grade squamous intraepithelial lesion |
| topic | HSIL positive margin LEEP |
| url | https://tci-thaijo.org/index.php/tjog/article/view/23049/107847 |
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