A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing
In this study, a new multifunctional double-ions macro-porous agarose hydrogel dressing is proposed, which successfully loaded Ag+ and Li+ simultaneously through the interaction of hydrogen bonds on carboxymethyl agarose (CMA) molecular chains and the interaction of carboxymethyl with metal ions. Th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127524002272 |
| _version_ | 1797214978499936256 |
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| author | Junlong Tian Jinyi Peng Chengjun Hu Shaorong Lei Dingyu Wu |
| author_facet | Junlong Tian Jinyi Peng Chengjun Hu Shaorong Lei Dingyu Wu |
| author_sort | Junlong Tian |
| collection | DOAJ |
| description | In this study, a new multifunctional double-ions macro-porous agarose hydrogel dressing is proposed, which successfully loaded Ag+ and Li+ simultaneously through the interaction of hydrogen bonds on carboxymethyl agarose (CMA) molecular chains and the interaction of carboxymethyl with metal ions. The macro-porous double-ions hydrogel dressing shows excellent biocompatibility, water-absorbing and water retention capabilities, as well as pH and temperature response characteristics. Moreover, Ag+ ions can be released in the early stage of treatment and Li+ ions can be released steadily and controlled for a long time throughout the treatment, which contributed to effectively antibacterial, and promote tissue regeneration, accelerate wound healing. Significantly, this work provides a general strategy for prepared multifunction double-ions hydrogel dressing with interconnected pores, not limited only to Ag+ and Li+ double-ions, but also Ag+ and Cu2+ double-ions, and Li+ and Cu2+ double-ions, and so on. Thus, the multifunction double-ions hydrogel exhibits a great potential in becoming an effective, efficient and economical wound management dressing. Moreover, this work presents a promising strategy in providing the agarose hydrogel wound dressing to achieve personalized customization ideas. |
| first_indexed | 2024-04-24T11:22:46Z |
| format | Article |
| id | doaj.art-be7bfeb87a634cc583dfd4d94b907a41 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-24T11:22:46Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-be7bfeb87a634cc583dfd4d94b907a412024-04-11T04:40:44ZengElsevierMaterials & Design0264-12752024-04-01240112854A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healingJunlong Tian0Jinyi Peng1Chengjun Hu2Shaorong Lei3Dingyu Wu4Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China; Hunan Key Laboratory of Micro-Nano Energy Materials and Devices, School of Physics and Optoelectronic, Xiangtan University, Xiangtan, Hunan 411105, China; Corresponding authors at: Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China (J. Tian).Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China; Hunan Key Laboratory of Micro-Nano Energy Materials and Devices, School of Physics and Optoelectronic, Xiangtan University, Xiangtan, Hunan 411105, ChinaDepartment of Plastic Surgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Plastic Surgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China; Corresponding authors at: Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China (J. Tian).Department of Plastic Surgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China; Corresponding authors at: Department of Electronic Science, College of Big Data and Information Engineering, Guizhou University, Guiyang 550025, China (J. Tian).In this study, a new multifunctional double-ions macro-porous agarose hydrogel dressing is proposed, which successfully loaded Ag+ and Li+ simultaneously through the interaction of hydrogen bonds on carboxymethyl agarose (CMA) molecular chains and the interaction of carboxymethyl with metal ions. The macro-porous double-ions hydrogel dressing shows excellent biocompatibility, water-absorbing and water retention capabilities, as well as pH and temperature response characteristics. Moreover, Ag+ ions can be released in the early stage of treatment and Li+ ions can be released steadily and controlled for a long time throughout the treatment, which contributed to effectively antibacterial, and promote tissue regeneration, accelerate wound healing. Significantly, this work provides a general strategy for prepared multifunction double-ions hydrogel dressing with interconnected pores, not limited only to Ag+ and Li+ double-ions, but also Ag+ and Cu2+ double-ions, and Li+ and Cu2+ double-ions, and so on. Thus, the multifunction double-ions hydrogel exhibits a great potential in becoming an effective, efficient and economical wound management dressing. Moreover, this work presents a promising strategy in providing the agarose hydrogel wound dressing to achieve personalized customization ideas.http://www.sciencedirect.com/science/article/pii/S0264127524002272Double-ions hydrogel dressingAntibacterialAnti-inflammatoryTissue regenerationWound healing |
| spellingShingle | Junlong Tian Jinyi Peng Chengjun Hu Shaorong Lei Dingyu Wu A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing Materials & Design Double-ions hydrogel dressing Antibacterial Anti-inflammatory Tissue regeneration Wound healing |
| title | A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing |
| title_full | A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing |
| title_fullStr | A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing |
| title_full_unstemmed | A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing |
| title_short | A general strategy for prepared multifunction double-ions agarose hydrogel dressing promotes wound healing |
| title_sort | general strategy for prepared multifunction double ions agarose hydrogel dressing promotes wound healing |
| topic | Double-ions hydrogel dressing Antibacterial Anti-inflammatory Tissue regeneration Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S0264127524002272 |
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