Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration
Abstract Immune checkpoint inhibitors (ICIs) have become a new hope for many patients with advanced cancer by blocking tumour immune evasion. However, with the widespread use of ICIs, immune‐related adverse events (irAEs) have also been discovered and reported increasingly. Immune‐related myocarditi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13912 |
| _version_ | 1811289002850910208 |
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| author | Zhijie Liu Yiming Fan Jun Guo Ning Bian Dongdong Chen |
| author_facet | Zhijie Liu Yiming Fan Jun Guo Ning Bian Dongdong Chen |
| author_sort | Zhijie Liu |
| collection | DOAJ |
| description | Abstract Immune checkpoint inhibitors (ICIs) have become a new hope for many patients with advanced cancer by blocking tumour immune evasion. However, with the widespread use of ICIs, immune‐related adverse events (irAEs) have also been discovered and reported increasingly. Immune‐related myocarditis, the most dangerous one of irAEs, still has high mortality in the context of the current treatment. We report the case of a 60‐year‐old female with fulminant myocarditis induced by ICIs, which caused her to experience frequent ventricular arrhythmias such as ventricular fibrillation and heart failure. She was successfully treated with current mainstream therapies for immune‐related myocarditis and additional treatment of sacubitril–valsartan and dapagliflozin. The intriguing observation that the patient condition recovered relatively rapidly in this case shows a possible treatment inspiration, which may be helpful for treating ICIs‐associated myocarditis and improving cancer patients' clinical prognosis. |
| first_indexed | 2024-04-13T03:47:16Z |
| format | Article |
| id | doaj.art-be7c79f164074137b970e0e109a36afc |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-13T03:47:16Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-be7c79f164074137b970e0e109a36afc2022-12-22T03:03:59ZengWileyESC Heart Failure2055-58222022-06-01932020202610.1002/ehf2.13912Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspirationZhijie Liu0Yiming Fan1Jun Guo2Ning Bian3Dongdong Chen4Department of Cardiology The First Affiliated Hospital of Jinan University Guangzhou 510630 ChinaDepartment of Cardiology The First Affiliated Hospital of Jinan University Guangzhou 510630 ChinaDepartment of Cardiology The First Affiliated Hospital of Jinan University Guangzhou 510630 ChinaDepartment of Cardiology The First Affiliated Hospital of Jinan University Guangzhou 510630 ChinaDepartment of Cardiology The First Affiliated Hospital of Jinan University Guangzhou 510630 ChinaAbstract Immune checkpoint inhibitors (ICIs) have become a new hope for many patients with advanced cancer by blocking tumour immune evasion. However, with the widespread use of ICIs, immune‐related adverse events (irAEs) have also been discovered and reported increasingly. Immune‐related myocarditis, the most dangerous one of irAEs, still has high mortality in the context of the current treatment. We report the case of a 60‐year‐old female with fulminant myocarditis induced by ICIs, which caused her to experience frequent ventricular arrhythmias such as ventricular fibrillation and heart failure. She was successfully treated with current mainstream therapies for immune‐related myocarditis and additional treatment of sacubitril–valsartan and dapagliflozin. The intriguing observation that the patient condition recovered relatively rapidly in this case shows a possible treatment inspiration, which may be helpful for treating ICIs‐associated myocarditis and improving cancer patients' clinical prognosis.https://doi.org/10.1002/ehf2.13912Immune checkpoint inhibitorsMyocarditisArrhythmiaSacubitril/valsartanSGLT2i |
| spellingShingle | Zhijie Liu Yiming Fan Jun Guo Ning Bian Dongdong Chen Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration ESC Heart Failure Immune checkpoint inhibitors Myocarditis Arrhythmia Sacubitril/valsartan SGLT2i |
| title | Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration |
| title_full | Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration |
| title_fullStr | Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration |
| title_full_unstemmed | Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration |
| title_short | Fulminant myocarditis caused by immune checkpoint inhibitor: a case report and possible treatment inspiration |
| title_sort | fulminant myocarditis caused by immune checkpoint inhibitor a case report and possible treatment inspiration |
| topic | Immune checkpoint inhibitors Myocarditis Arrhythmia Sacubitril/valsartan SGLT2i |
| url | https://doi.org/10.1002/ehf2.13912 |
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