Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis
Background: The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality. Methods: We searched PubMed, Google Scholar and World Health Organization library...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122001265 |
| _version_ | 1828832212922925056 |
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| author | Tafadzwa Dzinamarira Grant Murewanhema Itai Chitungo Bernard Ngara Sphamandla Josias Nkambule Roda Madziva Helena Herrera Solomon Mukwenha Diego F. Cuadros Patrick Gad Iradukunda Moreblessing Mashora Nigel Tungwarara Gallican Nshogoza Rwibasira Godfrey Musuka |
| author_facet | Tafadzwa Dzinamarira Grant Murewanhema Itai Chitungo Bernard Ngara Sphamandla Josias Nkambule Roda Madziva Helena Herrera Solomon Mukwenha Diego F. Cuadros Patrick Gad Iradukunda Moreblessing Mashora Nigel Tungwarara Gallican Nshogoza Rwibasira Godfrey Musuka |
| author_sort | Tafadzwa Dzinamarira |
| collection | DOAJ |
| description | Background: The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality. Methods: We searched PubMed, Google Scholar and World Health Organization library databases for relevant studies. All searches were conducted from 1st to 7th December 2021. Title, abstract and full text screening was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The relative risk of mortality in HIV-infected COVID-19 patients was computed using a random-effects model. All analyses were performed using Meta and Metasens statistical packages available in R version 4.2.1 software package. The quality of included studies was assessed using the GRADE approach, Egger’s test was employed to determine the risk of bias. Results: A total of 16 studies were included in this review. Among the COVID-19 patients with HIV infection, the mortality rate due to COVID-19 was 7.97% (4 287/53,801), and among the COVID-19 patients without HIV infection, the mortality rate due to COVID-19 was 0.69% (127, 961/18, 513, 747). In the random effects model, we found no statistically significant relative risk of mortality in HIV-infected COVID-19 patients (RR 1.07, 95% CI 0.86–1.32). The between-studies heterogeneity was substantial (I2 = 91%, P < 0.01), while the risk of publication bias was not significant. Conclusion: Findings did not link HIV infection with an increased risk of COVID-19 mortality. Our results add to the conflicting data on the relationship between COVID-19 and HIV infection. |
| first_indexed | 2024-12-12T16:47:52Z |
| format | Article |
| id | doaj.art-be7d0959d7294ec98c9958c3019d5fd3 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-12T16:47:52Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-be7d0959d7294ec98c9958c3019d5fd32022-12-22T00:18:25ZengElsevierJournal of Infection and Public Health1876-03412022-06-01156654661Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysisTafadzwa Dzinamarira0Grant Murewanhema1Itai Chitungo2Bernard Ngara3Sphamandla Josias Nkambule4Roda Madziva5Helena Herrera6Solomon Mukwenha7Diego F. Cuadros8Patrick Gad Iradukunda9Moreblessing Mashora10Nigel Tungwarara11Gallican Nshogoza Rwibasira12Godfrey Musuka13School of Health Systems & Public Health, University of Pretoria, Pretoria 0002, South Africa; ICAP at Columbia University, Harare, Zimbabwe; Corresponding author at: School of Health Systems & Public Health, University of Pretoria, Pretoria 0002, South Africa.Unit of Obstetrics and Gynaecology, Department of Primary Health Care Sciences, Faculty of Medicine and Health Sciences, University of Zimbabwe, ZimbabweFaculty of Medicine, College of Medicine and Health Sciences, University of Zimbabwe, Harare, ZimbabweFaculty of Medicine, College of Medicine and Health Sciences, University of Zimbabwe, Harare, ZimbabweDepartment of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban 4001, South AfricaUniversity of Nottingham, UKUniversity of Portsmouth, UKICAP at Columbia University, Harare, ZimbabweUniversity of Cincinnati, USALondon School of Hygiene and Tropical Medicine, University of London, London, UKDepartment of Public Health, Mount Kenya University, Kigali, RwandaDepartment of Health Studies, University of South Africa, South AfricaRwanda Biomedical Centre, Ministry of Health, Kigali, RwandaICAP at Columbia University, Harare, ZimbabweBackground: The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality. Methods: We searched PubMed, Google Scholar and World Health Organization library databases for relevant studies. All searches were conducted from 1st to 7th December 2021. Title, abstract and full text screening was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The relative risk of mortality in HIV-infected COVID-19 patients was computed using a random-effects model. All analyses were performed using Meta and Metasens statistical packages available in R version 4.2.1 software package. The quality of included studies was assessed using the GRADE approach, Egger’s test was employed to determine the risk of bias. Results: A total of 16 studies were included in this review. Among the COVID-19 patients with HIV infection, the mortality rate due to COVID-19 was 7.97% (4 287/53,801), and among the COVID-19 patients without HIV infection, the mortality rate due to COVID-19 was 0.69% (127, 961/18, 513, 747). In the random effects model, we found no statistically significant relative risk of mortality in HIV-infected COVID-19 patients (RR 1.07, 95% CI 0.86–1.32). The between-studies heterogeneity was substantial (I2 = 91%, P < 0.01), while the risk of publication bias was not significant. Conclusion: Findings did not link HIV infection with an increased risk of COVID-19 mortality. Our results add to the conflicting data on the relationship between COVID-19 and HIV infection.http://www.sciencedirect.com/science/article/pii/S1876034122001265COVID-19HIVAIDSMortalitySystematic reviewMeta-analysis |
| spellingShingle | Tafadzwa Dzinamarira Grant Murewanhema Itai Chitungo Bernard Ngara Sphamandla Josias Nkambule Roda Madziva Helena Herrera Solomon Mukwenha Diego F. Cuadros Patrick Gad Iradukunda Moreblessing Mashora Nigel Tungwarara Gallican Nshogoza Rwibasira Godfrey Musuka Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis Journal of Infection and Public Health COVID-19 HIV AIDS Mortality Systematic review Meta-analysis |
| title | Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis |
| title_full | Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis |
| title_fullStr | Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis |
| title_full_unstemmed | Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis |
| title_short | Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis |
| title_sort | risk of mortality in hiv infected covid 19 patients a systematic review and meta analysis |
| topic | COVID-19 HIV AIDS Mortality Systematic review Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122001265 |
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