Raman spectroscopy and group and basis-restricted non negative matrix factorisation identifies radiation induced metabolic changes in human cancer cells

Raman spectroscopy and group and basis-restricted non negative matrix factorisation identifies radiation induced metabolic changes in human cancer cells

Abstract This work combines single cell Raman spectroscopy (RS) with group and basis restricted non-negative matrix factorisation (GBR-NMF) to identify individual biochemical changes associated with radiation exposure in three human cancer cell lines. The cell lines analysed were derived from lung (...

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Bibliographic Details
Main Authors: Kirsty Milligan, Xinchen Deng, Phillip Shreeves, Ramie Ali-Adeeb, Quinn Matthews, Alexandre Brolo, Julian J. Lum, Jeffrey L. Andrews, Andrew Jirasek
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83343-5

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