Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis
Saliva has the potential to be used as a diagnostic and monitoring tool for various diseases if biomarkers of an adequate sensitivity and specificity could be identified. Several reviews and even meta-analyses have been performed in recent years, which have found some candidate biomarkers for period...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Dental Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2021.687638/full |
| _version_ | 1818589078079143936 |
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| author | Hady Haririan Oleh Andrukhov Markus Laky Xiaohui Rausch-Fan |
| author_facet | Hady Haririan Oleh Andrukhov Markus Laky Xiaohui Rausch-Fan |
| author_sort | Hady Haririan |
| collection | DOAJ |
| description | Saliva has the potential to be used as a diagnostic and monitoring tool for various diseases if biomarkers of an adequate sensitivity and specificity could be identified. Several reviews and even meta-analyses have been performed in recent years, which have found some candidate biomarkers for periodontitis, like macrophage inflammatory protein-1 alpha, interleukin-1ß, interleukin-6, matrix metalloproteinase-8, or hemoglobin. However, none of those are currently in use to replace conventional periodontal diagnostics with a periodontal probe. For periimplantitis, to date, heterogeneity of different study protocols and implant types did not permit to discover clear biomarkers, which were able to distinguish between healthy and diseased implants. Few proinflammatory cytokines, similar to periodontitis, have been characterized as adjunct tools to clinical diagnosis. The additional determination of antimicrobial peptides, bone turnover markers, and bacteria could help to enhance sensitivity and specificity in a combined model for periodontitis and periimplantitis. Furthermore, proteomic approaches might be preferred over single biomarker determinations. A global consensus is also needed to harmonize salivary sampling methods as well as procedures of biomarker analysis to ensure future comparability. |
| first_indexed | 2024-12-16T09:34:55Z |
| format | Article |
| id | doaj.art-be7e5f92facb4c91b84813cf6376f473 |
| institution | Directory Open Access Journal |
| issn | 2673-4915 |
| language | English |
| last_indexed | 2024-12-16T09:34:55Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj.art-be7e5f92facb4c91b84813cf6376f4732022-12-21T22:36:26ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152021-06-01210.3389/fdmed.2021.687638687638Saliva as a Source of Biomarkers for Periodontitis and PeriimplantitisHady Haririan0Oleh Andrukhov1Markus Laky2Xiaohui Rausch-Fan3Department of Periodontology, Faculty of Medicine, Sigmund Freud University Vienna, Vienna, AustriaDivision of Conservative Dentistry and Periodontology, University Dental Clinic, Medical University of Vienna, Vienna, AustriaDivision of Conservative Dentistry and Periodontology, University Dental Clinic, Medical University of Vienna, Vienna, AustriaDivision of Conservative Dentistry and Periodontology, University Dental Clinic, Medical University of Vienna, Vienna, AustriaSaliva has the potential to be used as a diagnostic and monitoring tool for various diseases if biomarkers of an adequate sensitivity and specificity could be identified. Several reviews and even meta-analyses have been performed in recent years, which have found some candidate biomarkers for periodontitis, like macrophage inflammatory protein-1 alpha, interleukin-1ß, interleukin-6, matrix metalloproteinase-8, or hemoglobin. However, none of those are currently in use to replace conventional periodontal diagnostics with a periodontal probe. For periimplantitis, to date, heterogeneity of different study protocols and implant types did not permit to discover clear biomarkers, which were able to distinguish between healthy and diseased implants. Few proinflammatory cytokines, similar to periodontitis, have been characterized as adjunct tools to clinical diagnosis. The additional determination of antimicrobial peptides, bone turnover markers, and bacteria could help to enhance sensitivity and specificity in a combined model for periodontitis and periimplantitis. Furthermore, proteomic approaches might be preferred over single biomarker determinations. A global consensus is also needed to harmonize salivary sampling methods as well as procedures of biomarker analysis to ensure future comparability.https://www.frontiersin.org/articles/10.3389/fdmed.2021.687638/fullsalivaperiodontitisperiimplantitisbiomarkersdiagnostics |
| spellingShingle | Hady Haririan Oleh Andrukhov Markus Laky Xiaohui Rausch-Fan Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis Frontiers in Dental Medicine saliva periodontitis periimplantitis biomarkers diagnostics |
| title | Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis |
| title_full | Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis |
| title_fullStr | Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis |
| title_full_unstemmed | Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis |
| title_short | Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis |
| title_sort | saliva as a source of biomarkers for periodontitis and periimplantitis |
| topic | saliva periodontitis periimplantitis biomarkers diagnostics |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2021.687638/full |
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