Role of anthraquinones in combating insulin resistance
Insulin resistance presents a formidable public health challenge that is intricately linked to the onset and progression of various chronic ailments, including diabetes, cardiovascular disease, hypertension, metabolic syndrome, nonalcoholic fatty liver disease, and cancer. Effectively addressing ins...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1275430/full |
| _version_ | 1797560218231504896 |
|---|---|
| author | Wanru Xia Shuqian Li LinZehao Li Shibo Zhang Xiaolei Wang Wenyu Ding Lina Ding Xiandang Zhang Zhibin Wang |
| author_facet | Wanru Xia Shuqian Li LinZehao Li Shibo Zhang Xiaolei Wang Wenyu Ding Lina Ding Xiandang Zhang Zhibin Wang |
| author_sort | Wanru Xia |
| collection | DOAJ |
| description | Insulin resistance presents a formidable public health challenge that is intricately linked to the onset and progression of various chronic ailments, including diabetes, cardiovascular disease, hypertension, metabolic syndrome, nonalcoholic fatty liver disease, and cancer. Effectively addressing insulin resistance is paramount in preventing and managing these metabolic disorders. Natural herbal remedies show promise in combating insulin resistance, with anthraquinone extracts garnering attention for their role in enhancing insulin sensitivity and treating diabetes. Anthraquinones are believed to ameliorate insulin resistance through diverse pathways, encompassing activation of the AMP-activated protein kinase (AMPK) signaling pathway, restoration of insulin signal transduction, attenuation of inflammatory pathways, and modulation of gut microbiota. This comprehensive review aims to consolidate the potential anthraquinone compounds that exert beneficial effects on insulin resistance, elucidating the underlying mechanisms responsible for their therapeutic impact. The evidence discussed in this review points toward the potential utilization of anthraquinones as a promising therapeutic strategy to combat insulin resistance and its associated metabolic diseases. |
| first_indexed | 2024-03-10T17:57:20Z |
| format | Article |
| id | doaj.art-be812f6b3660439aa7f6546cf826b9d7 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-10T17:57:20Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-be812f6b3660439aa7f6546cf826b9d72023-11-20T09:10:34ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-11-011410.3389/fphar.2023.12754301275430Role of anthraquinones in combating insulin resistanceWanru Xia0Shuqian Li1LinZehao Li2Shibo Zhang3Xiaolei Wang4Wenyu Ding5Lina Ding6Xiandang Zhang7Zhibin Wang8Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaShandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaEndocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaEndocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaEndocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaEndocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaEndocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaShandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaEndocrine and Metabolic Diseases Hospital of Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, ChinaInsulin resistance presents a formidable public health challenge that is intricately linked to the onset and progression of various chronic ailments, including diabetes, cardiovascular disease, hypertension, metabolic syndrome, nonalcoholic fatty liver disease, and cancer. Effectively addressing insulin resistance is paramount in preventing and managing these metabolic disorders. Natural herbal remedies show promise in combating insulin resistance, with anthraquinone extracts garnering attention for their role in enhancing insulin sensitivity and treating diabetes. Anthraquinones are believed to ameliorate insulin resistance through diverse pathways, encompassing activation of the AMP-activated protein kinase (AMPK) signaling pathway, restoration of insulin signal transduction, attenuation of inflammatory pathways, and modulation of gut microbiota. This comprehensive review aims to consolidate the potential anthraquinone compounds that exert beneficial effects on insulin resistance, elucidating the underlying mechanisms responsible for their therapeutic impact. The evidence discussed in this review points toward the potential utilization of anthraquinones as a promising therapeutic strategy to combat insulin resistance and its associated metabolic diseases.https://www.frontiersin.org/articles/10.3389/fphar.2023.1275430/fullanthraquinonesinsulin resistancenatural productsintestinal microbiomeantiinflammation |
| spellingShingle | Wanru Xia Shuqian Li LinZehao Li Shibo Zhang Xiaolei Wang Wenyu Ding Lina Ding Xiandang Zhang Zhibin Wang Role of anthraquinones in combating insulin resistance Frontiers in Pharmacology anthraquinones insulin resistance natural products intestinal microbiome antiinflammation |
| title | Role of anthraquinones in combating insulin resistance |
| title_full | Role of anthraquinones in combating insulin resistance |
| title_fullStr | Role of anthraquinones in combating insulin resistance |
| title_full_unstemmed | Role of anthraquinones in combating insulin resistance |
| title_short | Role of anthraquinones in combating insulin resistance |
| title_sort | role of anthraquinones in combating insulin resistance |
| topic | anthraquinones insulin resistance natural products intestinal microbiome antiinflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1275430/full |
| work_keys_str_mv | AT wanruxia roleofanthraquinonesincombatinginsulinresistance AT shuqianli roleofanthraquinonesincombatinginsulinresistance AT linzehaoli roleofanthraquinonesincombatinginsulinresistance AT shibozhang roleofanthraquinonesincombatinginsulinresistance AT xiaoleiwang roleofanthraquinonesincombatinginsulinresistance AT wenyuding roleofanthraquinonesincombatinginsulinresistance AT linading roleofanthraquinonesincombatinginsulinresistance AT xiandangzhang roleofanthraquinonesincombatinginsulinresistance AT zhibinwang roleofanthraquinonesincombatinginsulinresistance |