Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy
BackgroundThe prognosis of patients with dilated cardiomyopathy (DCM) is poor and new indicators are urgently needed to predict lethal cardiac events. This study aimed to investigate the value of summed motion score (SMS) in predicting cardiac death of DCM patients using gated single photon emission...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1144333/full |
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| author | Jun-Yan Zhu Jun-Yan Zhu Jun-Yan Zhu Xin-Chao Wang Xin-Chao Wang Nan Huang Xiao-Qian Li Yan Cheng Yan Cheng Zhi-Fang Wu Zhi-Fang Wu Yuan-Yuan Li Yuan-Yuan Li Yuan-Yuan Li Ping Wu Ping Wu Li Li Li Li Hua Wei Si-Jin Li Si-Jin Li Ji-Min Cao Ji-Min Cao |
| author_facet | Jun-Yan Zhu Jun-Yan Zhu Jun-Yan Zhu Xin-Chao Wang Xin-Chao Wang Nan Huang Xiao-Qian Li Yan Cheng Yan Cheng Zhi-Fang Wu Zhi-Fang Wu Yuan-Yuan Li Yuan-Yuan Li Yuan-Yuan Li Ping Wu Ping Wu Li Li Li Li Hua Wei Si-Jin Li Si-Jin Li Ji-Min Cao Ji-Min Cao |
| author_sort | Jun-Yan Zhu |
| collection | DOAJ |
| description | BackgroundThe prognosis of patients with dilated cardiomyopathy (DCM) is poor and new indicators are urgently needed to predict lethal cardiac events. This study aimed to investigate the value of summed motion score (SMS) in predicting cardiac death of DCM patients using gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).Methods and resultsEighty-one patients with DCM who underwent 99mTc-MIBI gated SPECT MPI were retrospectively enrolled and were divided into cardiac death and survivor groups. The functional parameters of left ventricle including SMS were measured using quantitative gated SPECT software. During the follow-up period of 44 (25, 54) months, 14 (17.28%) cardiac deaths were observed. Compared with the survivor group, SMS was significantly higher in the cardiac death group. Multivariate cox regression analysis showed that SMS was an independent predictor for cardiac death (HR 1.34, 95% CI 1.02–1.77, P = 0.034). SMS also provided incremental prognostic value over other variables in the multivariate model as determined by likelihood ratio global chi-squared test. In the Kaplan-Meier survival analysis, the event-free survival rate was significantly lower in the high-SMS (HSMS) group than the low-SMS (LSMS) (log-rank P < 0.001). Furthermore, the area under curve (AUC) of SMS was larger than that of LVEF at the 12th month of follow-up (0.85 vs. 0.80, P = 0.045).ConclusionSMS is an independent predictor of cardiac death in DCM patients and provides incremental prognostic value. SMS might have higher predictive value than LVEF for early cardiac death. |
| first_indexed | 2024-04-10T00:29:07Z |
| format | Article |
| id | doaj.art-be863d8091fb4092bb5c1b4d7e00369b |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T00:29:07Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-be863d8091fb4092bb5c1b4d7e00369b2023-03-15T04:35:46ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.11443331144333Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathyJun-Yan Zhu0Jun-Yan Zhu1Jun-Yan Zhu2Xin-Chao Wang3Xin-Chao Wang4Nan Huang5Xiao-Qian Li6Yan Cheng7Yan Cheng8Zhi-Fang Wu9Zhi-Fang Wu10Yuan-Yuan Li11Yuan-Yuan Li12Yuan-Yuan Li13Ping Wu14Ping Wu15Li Li16Li Li17Hua Wei18Si-Jin Li19Si-Jin Li20Ji-Min Cao21Ji-Min Cao22Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, ChinaDepartment of Physiology, Shanxi Medical University, Taiyuan, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaSchool of Public Health, Shanxi Medical University, Taiyuan, ChinaCollaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaCollaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaCollaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, ChinaDepartment of Physiology, Shanxi Medical University, Taiyuan, ChinaDepartment of Critical Care Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaCollaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaCollaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, ChinaKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, ChinaDepartment of Physiology, Shanxi Medical University, Taiyuan, ChinaBackgroundThe prognosis of patients with dilated cardiomyopathy (DCM) is poor and new indicators are urgently needed to predict lethal cardiac events. This study aimed to investigate the value of summed motion score (SMS) in predicting cardiac death of DCM patients using gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).Methods and resultsEighty-one patients with DCM who underwent 99mTc-MIBI gated SPECT MPI were retrospectively enrolled and were divided into cardiac death and survivor groups. The functional parameters of left ventricle including SMS were measured using quantitative gated SPECT software. During the follow-up period of 44 (25, 54) months, 14 (17.28%) cardiac deaths were observed. Compared with the survivor group, SMS was significantly higher in the cardiac death group. Multivariate cox regression analysis showed that SMS was an independent predictor for cardiac death (HR 1.34, 95% CI 1.02–1.77, P = 0.034). SMS also provided incremental prognostic value over other variables in the multivariate model as determined by likelihood ratio global chi-squared test. In the Kaplan-Meier survival analysis, the event-free survival rate was significantly lower in the high-SMS (HSMS) group than the low-SMS (LSMS) (log-rank P < 0.001). Furthermore, the area under curve (AUC) of SMS was larger than that of LVEF at the 12th month of follow-up (0.85 vs. 0.80, P = 0.045).ConclusionSMS is an independent predictor of cardiac death in DCM patients and provides incremental prognostic value. SMS might have higher predictive value than LVEF for early cardiac death.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1144333/fulldilated cardiomyopathyprognosticsoutcomewall motiongated SPECT |
| spellingShingle | Jun-Yan Zhu Jun-Yan Zhu Jun-Yan Zhu Xin-Chao Wang Xin-Chao Wang Nan Huang Xiao-Qian Li Yan Cheng Yan Cheng Zhi-Fang Wu Zhi-Fang Wu Yuan-Yuan Li Yuan-Yuan Li Yuan-Yuan Li Ping Wu Ping Wu Li Li Li Li Hua Wei Si-Jin Li Si-Jin Li Ji-Min Cao Ji-Min Cao Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy Frontiers in Cardiovascular Medicine dilated cardiomyopathy prognostics outcome wall motion gated SPECT |
| title | Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy |
| title_full | Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy |
| title_fullStr | Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy |
| title_full_unstemmed | Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy |
| title_short | Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy |
| title_sort | prognostic value of summed motion score assessed by gated spect myocardial perfusion imaging in patients with dilated cardiomyopathy |
| topic | dilated cardiomyopathy prognostics outcome wall motion gated SPECT |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1144333/full |
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