Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitis
Abstract Inflammatory dermatoses are prevalent worldwide, with impacts on the quality of life of patients and their families. The aim of this study was to determine the anti-inflammatory effects of Achyrocline satureioides oily extracts and nanocapsules on the skin using a mouse model of irritant co...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Ciências
2020-11-01
|
| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700906&tlng=en |
| _version_ | 1828126188093046784 |
|---|---|
| author | VANESSA S. MACHADO CAMILA CAMPONOGARA SARA M. OLIVEIRA MATHEUS D. BALDISSERA MICHELE R. SAGRILLO SAMANTA DA S. GUNDEL ANA PAULA T. DA SILVA ALINE F. OURIQUE BRUNA KLEIN ROGER WAGNER ROBERTO C.V. SANTOS ALEKSANDRO S. DA SILVA |
| author_facet | VANESSA S. MACHADO CAMILA CAMPONOGARA SARA M. OLIVEIRA MATHEUS D. BALDISSERA MICHELE R. SAGRILLO SAMANTA DA S. GUNDEL ANA PAULA T. DA SILVA ALINE F. OURIQUE BRUNA KLEIN ROGER WAGNER ROBERTO C.V. SANTOS ALEKSANDRO S. DA SILVA |
| author_sort | VANESSA S. MACHADO |
| collection | DOAJ |
| description | Abstract Inflammatory dermatoses are prevalent worldwide, with impacts on the quality of life of patients and their families. The aim of this study was to determine the anti-inflammatory effects of Achyrocline satureioides oily extracts and nanocapsules on the skin using a mouse model of irritant contact dermatitis induced by croton oil, and a skin inflammation model induced by ultraviolet B (UVB) radiation. The mice were treated with 15 mg/ear oily extract (HG-OLAS) or nanocapsules (HG-NCAS) of A. satureioides incorporated into Carbopol® 940 hydrogels. We found that HG-OLAS and HG-NCAS formulations reduced ear edema in croton oil-induced lesions with maximum inhibitions of 54±7% and 74±3%, respectively. HG-OLAS and HG-NCAS formulations decreased ear edema induced by UVB radiation (0.5 J/cm2), with maximum inhibitions of 68±6% and 76±2% compared to the UVB radiation group, respectively. HG-OLAS and HG-NCAS modulated myeloperoxidase (MPO) activity after croton oil induction. Furthermore, croton oil and UVB radiation for 6 and 24 h, respectively, stimulated polymorphonuclear cells infiltration. The topical treatments reduced inflammatory processes, as shown by histological analysis. Together, the data suggest that topical application of A. satureioides oily extracts and nanocapsules produced antiedematogenic and anti-inflammatory effects. They constitute a compelling alternative for treatment of skin injuries. |
| first_indexed | 2024-04-11T15:31:42Z |
| format | Article |
| id | doaj.art-be86b5387e8243ff84e2539099b2dd42 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-11T15:31:42Z |
| publishDate | 2020-11-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-be86b5387e8243ff84e2539099b2dd422022-12-22T04:16:08ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902020-11-0192410.1590/0001-3765202020191066Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitisVANESSA S. MACHADOhttps://orcid.org/0000-0001-6839-3021CAMILA CAMPONOGARAhttps://orcid.org/0000-0003-0283-7931SARA M. OLIVEIRAhttps://orcid.org/0000-0002-2148-9250MATHEUS D. BALDISSERAhttps://orcid.org/0000-0002-3280-8528MICHELE R. SAGRILLOhttps://orcid.org/0000-0001-5659-159XSAMANTA DA S. GUNDELhttps://orcid.org/0000-0003-4708-6801ANA PAULA T. DA SILVAhttps://orcid.org/0000-0002-9393-0682ALINE F. OURIQUEhttps://orcid.org/0000-0003-0828-774XBRUNA KLEINhttps://orcid.org/0000-0002-9986-3118ROGER WAGNERhttps://orcid.org/0000-0002-6176-7913ROBERTO C.V. SANTOShttps://orcid.org/0000-0002-0533-3483ALEKSANDRO S. DA SILVAhttps://orcid.org/0000-0002-6940-6776Abstract Inflammatory dermatoses are prevalent worldwide, with impacts on the quality of life of patients and their families. The aim of this study was to determine the anti-inflammatory effects of Achyrocline satureioides oily extracts and nanocapsules on the skin using a mouse model of irritant contact dermatitis induced by croton oil, and a skin inflammation model induced by ultraviolet B (UVB) radiation. The mice were treated with 15 mg/ear oily extract (HG-OLAS) or nanocapsules (HG-NCAS) of A. satureioides incorporated into Carbopol® 940 hydrogels. We found that HG-OLAS and HG-NCAS formulations reduced ear edema in croton oil-induced lesions with maximum inhibitions of 54±7% and 74±3%, respectively. HG-OLAS and HG-NCAS formulations decreased ear edema induced by UVB radiation (0.5 J/cm2), with maximum inhibitions of 68±6% and 76±2% compared to the UVB radiation group, respectively. HG-OLAS and HG-NCAS modulated myeloperoxidase (MPO) activity after croton oil induction. Furthermore, croton oil and UVB radiation for 6 and 24 h, respectively, stimulated polymorphonuclear cells infiltration. The topical treatments reduced inflammatory processes, as shown by histological analysis. Together, the data suggest that topical application of A. satureioides oily extracts and nanocapsules produced antiedematogenic and anti-inflammatory effects. They constitute a compelling alternative for treatment of skin injuries.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700906&tlng=enUVB radiationcroton oilmacelananocapsulesskin injuriesanti-inflammatory |
| spellingShingle | VANESSA S. MACHADO CAMILA CAMPONOGARA SARA M. OLIVEIRA MATHEUS D. BALDISSERA MICHELE R. SAGRILLO SAMANTA DA S. GUNDEL ANA PAULA T. DA SILVA ALINE F. OURIQUE BRUNA KLEIN ROGER WAGNER ROBERTO C.V. SANTOS ALEKSANDRO S. DA SILVA Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitis Anais da Academia Brasileira de Ciências UVB radiation croton oil macela nanocapsules skin injuries anti-inflammatory |
| title | Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitis |
| title_full | Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitis |
| title_fullStr | Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitis |
| title_full_unstemmed | Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitis |
| title_short | Topical hydrogel containing Achyrocline satureioides oily extract (free and nanocapsule) has anti-inflammatory effects and thereby minimizes irritant contact dermatitis |
| title_sort | topical hydrogel containing achyrocline satureioides oily extract free and nanocapsule has anti inflammatory effects and thereby minimizes irritant contact dermatitis |
| topic | UVB radiation croton oil macela nanocapsules skin injuries anti-inflammatory |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700906&tlng=en |
| work_keys_str_mv | AT vanessasmachado topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT camilacamponogara topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT saramoliveira topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT matheusdbaldissera topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT michelersagrillo topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT samantadasgundel topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT anapaulatdasilva topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT alinefourique topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT brunaklein topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT rogerwagner topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT robertocvsantos topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis AT aleksandrosdasilva topicalhydrogelcontainingachyroclinesatureioidesoilyextractfreeandnanocapsulehasantiinflammatoryeffectsandtherebyminimizesirritantcontactdermatitis |