Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway
Silicosis is a pulmonary disease caused by the inhalation of silica. There is a lack of early and effective prevention, diagnosis, and treatment methods, and addressing silicotic fibrosis is crucial. Quercetin, a flavonoid with anti-carcinogenic, anti-inflammatory, and antiviral properties, is known...
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MDPI AG
2023-04-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/4/202 |
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| author | Fei Geng Lan Zhao Yuhao Cai Ying Zhao Fuyu Jin Yaqian Li Tian Li Xinyu Yang Shifeng Li Xuemin Gao Wenchen Cai Na Mao Ying Sun Hong Xu Zhongqiu Wei Fang Yang |
| author_facet | Fei Geng Lan Zhao Yuhao Cai Ying Zhao Fuyu Jin Yaqian Li Tian Li Xinyu Yang Shifeng Li Xuemin Gao Wenchen Cai Na Mao Ying Sun Hong Xu Zhongqiu Wei Fang Yang |
| author_sort | Fei Geng |
| collection | DOAJ |
| description | Silicosis is a pulmonary disease caused by the inhalation of silica. There is a lack of early and effective prevention, diagnosis, and treatment methods, and addressing silicotic fibrosis is crucial. Quercetin, a flavonoid with anti-carcinogenic, anti-inflammatory, and antiviral properties, is known to have a suppressive effect on fibrosis. The present study aimed to determine the therapeutic effect of quercetin on silicotic mice and macrophage polarity. We found that quercetin suppressed silicosis in mice. It was observed that SiO<sub>2</sub> activated macrophage polarity and the macrophage-to-myofibroblast transition (MMT) by transforming the growth factor-β (TGF-β)-Smad2/3 signaling pathway in silicotic mice and MH-S cells. Quercetin also attenuated the MMT and the TGF-β-Smad2/3 signaling pathway in vivo and in vitro. The present study demonstrated that quercetin is a potential therapeutic agent for silicosis, which acts by regulating macrophage polarity and the MMT through the TGF-β-Smad2/3 signaling pathway. |
| first_indexed | 2024-03-11T05:08:22Z |
| format | Article |
| id | doaj.art-be8755b8643349c1a21bae5dd79b21ba |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T05:08:22Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-be8755b8643349c1a21bae5dd79b21ba2023-11-17T18:47:42ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-04-014543087310110.3390/cimb45040202Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 PathwayFei Geng0Lan Zhao1Yuhao Cai2Ying Zhao3Fuyu Jin4Yaqian Li5Tian Li6Xinyu Yang7Shifeng Li8Xuemin Gao9Wenchen Cai10Na Mao11Ying Sun12Hong Xu13Zhongqiu Wei14Fang Yang15School of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Basic Medical Sciences, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan 063210, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Basic Medical Sciences, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan 063210, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSchool of Basic Medical Sciences, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan 063210, ChinaSchool of Public Health, Hebei Key Laboratory for Organ Fibrosis Research, North China University of Science and Technology, Tangshan 063000, ChinaSilicosis is a pulmonary disease caused by the inhalation of silica. There is a lack of early and effective prevention, diagnosis, and treatment methods, and addressing silicotic fibrosis is crucial. Quercetin, a flavonoid with anti-carcinogenic, anti-inflammatory, and antiviral properties, is known to have a suppressive effect on fibrosis. The present study aimed to determine the therapeutic effect of quercetin on silicotic mice and macrophage polarity. We found that quercetin suppressed silicosis in mice. It was observed that SiO<sub>2</sub> activated macrophage polarity and the macrophage-to-myofibroblast transition (MMT) by transforming the growth factor-β (TGF-β)-Smad2/3 signaling pathway in silicotic mice and MH-S cells. Quercetin also attenuated the MMT and the TGF-β-Smad2/3 signaling pathway in vivo and in vitro. The present study demonstrated that quercetin is a potential therapeutic agent for silicosis, which acts by regulating macrophage polarity and the MMT through the TGF-β-Smad2/3 signaling pathway.https://www.mdpi.com/1467-3045/45/4/202quercetinmacrophage-to-myofibroblast transitionsilicosis |
| spellingShingle | Fei Geng Lan Zhao Yuhao Cai Ying Zhao Fuyu Jin Yaqian Li Tian Li Xinyu Yang Shifeng Li Xuemin Gao Wenchen Cai Na Mao Ying Sun Hong Xu Zhongqiu Wei Fang Yang Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway Current Issues in Molecular Biology quercetin macrophage-to-myofibroblast transition silicosis |
| title | Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway |
| title_full | Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway |
| title_fullStr | Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway |
| title_full_unstemmed | Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway |
| title_short | Quercetin Alleviates Pulmonary Fibrosis in Silicotic Mice by Inhibiting Macrophage Transition and TGF-β-Smad2/3 Pathway |
| title_sort | quercetin alleviates pulmonary fibrosis in silicotic mice by inhibiting macrophage transition and tgf β smad2 3 pathway |
| topic | quercetin macrophage-to-myofibroblast transition silicosis |
| url | https://www.mdpi.com/1467-3045/45/4/202 |
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