Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy

Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy

Mitochondrial biosynthesis regulated by the PGC-1α-NRF1-TFAM pathway is considered a novel potential therapeutic target to treat heart failure (HF). Perindopril (PER) is an angiotensin-converting enzyme inhibitor that has proven efficacy in the prevention of HF; however, its mechanism is not well es...

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Bibliographic Details
Main Authors: Zhenyu Zhu, Huihui Li, Wanli Chen, Yameng Cui, Anan Huang, Xin Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
perindopril
heart failure
PGC-1α
mitochondrial biosynthesis
oxidative stress
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00094/full

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