Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With Tetraplegia
Individuals with tetraplegia identify restoration of hand function as a critical, unmet need to regain their independence and improve quality of life. Brain-Computer Interface (BCI)-controlled Functional Electrical Stimulation (FES) technology addresses this need by reconnecting the brain with paral...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2018.00208/full |
| _version_ | 1811195285777416192 |
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| author | Samuel C. Colachis Samuel C. Colachis Samuel C. Colachis Marcie A. Bockbrader Marcie A. Bockbrader Marcie A. Bockbrader Mingming Zhang David A. Friedenberg Nicholas V. Annetta Michael A. Schwemmer Nicholas D. Skomrock Walter J. Mysiw Walter J. Mysiw Ali R. Rezai Herbert S. Bresler Gaurav Sharma |
| author_facet | Samuel C. Colachis Samuel C. Colachis Samuel C. Colachis Marcie A. Bockbrader Marcie A. Bockbrader Marcie A. Bockbrader Mingming Zhang David A. Friedenberg Nicholas V. Annetta Michael A. Schwemmer Nicholas D. Skomrock Walter J. Mysiw Walter J. Mysiw Ali R. Rezai Herbert S. Bresler Gaurav Sharma |
| author_sort | Samuel C. Colachis |
| collection | DOAJ |
| description | Individuals with tetraplegia identify restoration of hand function as a critical, unmet need to regain their independence and improve quality of life. Brain-Computer Interface (BCI)-controlled Functional Electrical Stimulation (FES) technology addresses this need by reconnecting the brain with paralyzed limbs to restore function. In this study, we quantified performance of an intuitive, cortically-controlled, transcutaneous FES system on standardized object manipulation tasks from the Grasp and Release Test (GRT). We found that a tetraplegic individual could use the system to control up to seven functional hand movements, each with >95% individual accuracy. He was able to select one movement from the possible seven movements available to him and use it to appropriately manipulate all GRT objects in real-time using naturalistic grasps. With the use of the system, the participant not only improved his GRT performance over his baseline, demonstrating an increase in number of transfers for all objects except the Block, but also significantly improved transfer times for the heaviest objects (videocassette (VHS), Can). Analysis of underlying motor cortex neural representations associated with the hand grasp states revealed an overlap or non-separability in neural activation patterns for similarly shaped objects that affected BCI-FES performance. These results suggest that motor cortex neural representations for functional grips are likely more related to hand shape and force required to hold objects, rather than to the objects themselves. These results, demonstrating multiple, naturalistic functional hand movements with the BCI-FES, constitute a further step toward translating BCI-FES technologies from research devices to clinical neuroprosthetics. |
| first_indexed | 2024-04-12T00:41:00Z |
| format | Article |
| id | doaj.art-be880f0356b649518a700aae1d8ef689 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T00:41:00Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-be880f0356b649518a700aae1d8ef6892022-12-22T03:55:01ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-04-011210.3389/fnins.2018.00208313435Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With TetraplegiaSamuel C. Colachis0Samuel C. Colachis1Samuel C. Colachis2Marcie A. Bockbrader3Marcie A. Bockbrader4Marcie A. Bockbrader5Mingming Zhang6David A. Friedenberg7Nicholas V. Annetta8Michael A. Schwemmer9Nicholas D. Skomrock10Walter J. Mysiw11Walter J. Mysiw12Ali R. Rezai13Herbert S. Bresler14Gaurav Sharma15Medical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United StatesNeurological Institute, The Ohio State University, Columbus, OH, United StatesDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, United StatesNeurological Institute, The Ohio State University, Columbus, OH, United StatesDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, United StatesDepartment of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH, United StatesMedical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United StatesAdvanced Analytics Group, Battelle Memorial Institute, Columbus, OH, United StatesMedical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United StatesAdvanced Analytics Group, Battelle Memorial Institute, Columbus, OH, United StatesAdvanced Analytics Group, Battelle Memorial Institute, Columbus, OH, United StatesNeurological Institute, The Ohio State University, Columbus, OH, United StatesDepartment of Physical Medicine and Rehabilitation, The Ohio State University, Columbus, OH, United StatesNeurological Institute, The Ohio State University, Columbus, OH, United StatesMedical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United StatesMedical Devices and Neuromodulation Group, Battelle Memorial Institute, Columbus, OH, United StatesIndividuals with tetraplegia identify restoration of hand function as a critical, unmet need to regain their independence and improve quality of life. Brain-Computer Interface (BCI)-controlled Functional Electrical Stimulation (FES) technology addresses this need by reconnecting the brain with paralyzed limbs to restore function. In this study, we quantified performance of an intuitive, cortically-controlled, transcutaneous FES system on standardized object manipulation tasks from the Grasp and Release Test (GRT). We found that a tetraplegic individual could use the system to control up to seven functional hand movements, each with >95% individual accuracy. He was able to select one movement from the possible seven movements available to him and use it to appropriately manipulate all GRT objects in real-time using naturalistic grasps. With the use of the system, the participant not only improved his GRT performance over his baseline, demonstrating an increase in number of transfers for all objects except the Block, but also significantly improved transfer times for the heaviest objects (videocassette (VHS), Can). Analysis of underlying motor cortex neural representations associated with the hand grasp states revealed an overlap or non-separability in neural activation patterns for similarly shaped objects that affected BCI-FES performance. These results suggest that motor cortex neural representations for functional grips are likely more related to hand shape and force required to hold objects, rather than to the objects themselves. These results, demonstrating multiple, naturalistic functional hand movements with the BCI-FES, constitute a further step toward translating BCI-FES technologies from research devices to clinical neuroprosthetics.http://journal.frontiersin.org/article/10.3389/fnins.2018.00208/fullbrain-computer interfacefunctional electrical stimulationspinal cord injuryneuro-orthoticsfunctional hand grasping |
| spellingShingle | Samuel C. Colachis Samuel C. Colachis Samuel C. Colachis Marcie A. Bockbrader Marcie A. Bockbrader Marcie A. Bockbrader Mingming Zhang David A. Friedenberg Nicholas V. Annetta Michael A. Schwemmer Nicholas D. Skomrock Walter J. Mysiw Walter J. Mysiw Ali R. Rezai Herbert S. Bresler Gaurav Sharma Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With Tetraplegia Frontiers in Neuroscience brain-computer interface functional electrical stimulation spinal cord injury neuro-orthotics functional hand grasping |
| title | Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With Tetraplegia |
| title_full | Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With Tetraplegia |
| title_fullStr | Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With Tetraplegia |
| title_full_unstemmed | Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With Tetraplegia |
| title_short | Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With Tetraplegia |
| title_sort | dexterous control of seven functional hand movements using cortically controlled transcutaneous muscle stimulation in a person with tetraplegia |
| topic | brain-computer interface functional electrical stimulation spinal cord injury neuro-orthotics functional hand grasping |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2018.00208/full |
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