Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea
Abstract Background Community–acquired pneumonia (CAP) is one of the leading worldwide causes of childhood morbidity and mortality. Its disease burden varies by age and etiology and is time dependent. We aimed to investigate the annual and seasonal patterns in etiologies of pediatric CAP requiring h...
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| Format: | Article |
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BMC
2020-02-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-020-4810-9 |
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| author | Eun Lee Chul-Hong Kim Yong Ju Lee Hyo-Bin Kim Bong-Seong Kim Hyung Young Kim Yunsun Kim Sangyoung Kim Chorong Park Ju-Hee Seo In Suk Sol Myongsoon Sung Min Seob Song Dae Jin Song Young Min Ahn Hea Lin Oh Jinho Yu Sungsu Jung Kyung Suk Lee Ju Suk Lee Gwang Cheon Jang Yoon-Young Jang Eun Hee Chung Hai Lee Chung Sung-Min Choi Yun Jung Choi Man Yong Han Jung Yeon Shim Jin Tack Kim Chang-Keun Kim Hyeon-Jong Yang Pneumonia and Respiratory Disease Study Group of Korean Academy of Pediatric Allergy and Respiratory Disease |
| author_facet | Eun Lee Chul-Hong Kim Yong Ju Lee Hyo-Bin Kim Bong-Seong Kim Hyung Young Kim Yunsun Kim Sangyoung Kim Chorong Park Ju-Hee Seo In Suk Sol Myongsoon Sung Min Seob Song Dae Jin Song Young Min Ahn Hea Lin Oh Jinho Yu Sungsu Jung Kyung Suk Lee Ju Suk Lee Gwang Cheon Jang Yoon-Young Jang Eun Hee Chung Hai Lee Chung Sung-Min Choi Yun Jung Choi Man Yong Han Jung Yeon Shim Jin Tack Kim Chang-Keun Kim Hyeon-Jong Yang Pneumonia and Respiratory Disease Study Group of Korean Academy of Pediatric Allergy and Respiratory Disease |
| author_sort | Eun Lee |
| collection | DOAJ |
| description | Abstract Background Community–acquired pneumonia (CAP) is one of the leading worldwide causes of childhood morbidity and mortality. Its disease burden varies by age and etiology and is time dependent. We aimed to investigate the annual and seasonal patterns in etiologies of pediatric CAP requiring hospitalization. Methods We conducted a retrospective study in 30,994 children (aged 0–18 years) with CAP between 2010 and 2015 at 23 nationwide hospitals in South Korea. Mycoplasma pneumoniae (MP) pneumonia was clinically classified as macrolide-sensitive MP, macrolide-less effective MP (MLEP), and macrolide-refractory MP (MRMP) based on fever duration after initiation of macrolide treatment, regardless of the results of in vitro macrolide sensitivity tests. Results MP and respiratory syncytial virus (RSV) were the two most commonly identified pathogens of CAP. With the two epidemics of MP pneumonia (2011 and 2015), the rates of clinical MLEP and MRMP pneumonia showed increasing trends of 36.4% of the total MP pneumonia. In children < 2 years of age, RSV (34.0%) was the most common cause of CAP, followed by MP (9.4%); however, MP was the most common cause of CAP in children aged 2–18 years of age (45.3%). Systemic corticosteroid was most commonly administered for MP pneumonia. The rate of hospitalization in intensive care units was the highest for RSV pneumonia, and ventilator care was most commonly needed in cases of adenovirus pneumonia. Conclusions The present study provides fundamental data to establish public health policies to decrease the disease burden due to CAP and improve pediatric health. |
| first_indexed | 2024-12-17T05:44:00Z |
| format | Article |
| id | doaj.art-be894586018a4eb5a3a2361027649df6 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-17T05:44:00Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-be894586018a4eb5a3a2361027649df62022-12-21T22:01:21ZengBMCBMC Infectious Diseases1471-23342020-02-0120111010.1186/s12879-020-4810-9Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South KoreaEun Lee0Chul-Hong Kim1Yong Ju Lee2Hyo-Bin Kim3Bong-Seong Kim4Hyung Young Kim5Yunsun Kim6Sangyoung Kim7Chorong Park8Ju-Hee Seo9In Suk Sol10Myongsoon Sung11Min Seob Song12Dae Jin Song13Young Min Ahn14Hea Lin Oh15Jinho Yu16Sungsu Jung17Kyung Suk Lee18Ju Suk Lee19Gwang Cheon Jang20Yoon-Young Jang21Eun Hee Chung22Hai Lee Chung23Sung-Min Choi24Yun Jung Choi25Man Yong Han26Jung Yeon Shim27Jin Tack Kim28Chang-Keun Kim29Hyeon-Jong Yang30Pneumonia and Respiratory Disease Study Group of Korean Academy of Pediatric Allergy and Respiratory DiseaseDepartment of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical SchoolDepartment of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of MedicineDepartment of Pediatrics, Hallym University Kangnam Sacred Heart HospitalAsthma and Allergy Center, Department of Pediatrics, Inje University Sanggye Paik HospitalDepartment of Pediatrics, Ulsan University Gangneung Asan HospitalDepartment of Pediatrics, Pusan National University Children’s HospitalSCH Biomedical Informatics Research Unit, Soonchunhyang University Seoul HospitalSCH Biomedical Informatics Research Unit, Soonchunhyang University Seoul HospitalSCH Biomedical Informatics Research Unit, Soonchunhyang University Seoul HospitalDepartment of Pediatrics, Dankook University Hospital, Dankook University Medical SchoolDepartment of Pediatrics, Hallym University Chuncheon Sacred Heart HospitalDepartment of Pediatrics, Soonchunhyang University Gumi HospitalDepartment of Pediatrics, Inje University Haeundae Paik HospitalDepartment of Pediatrics, Korea University Guro Hospital, Korea University College of MedicineDepartment of Pediatrics, Eulji University, Eulji General HospitalDepartment of Pediatrics, Korea Cancer Center HospitalDepartment of Pediatrics, Asan Medical Center, Ulsan University Medical SchoolDepartment of Pediatrics, Pusan National University Children’s HospitalDepartment of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of MedicineDepartment of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of MedicineDepartment of Pediatrics, National Health Insurance Service, Ilsan HospitalDepartment of Pediatrics, Catholic University of Daegu School of MedicineDepartment of Pediatrics, Chungnam National University Hospital, Chungnam National University School of MedicineDepartment of Pediatrics, Catholic University of Daegu School of MedicineDepartment of Pediatrics, Dongguk University Kyungju HospitalDepartment of Pediatrics, Seoul National University Children HospitalDepartment of Pediatrics, CHA Bundang Medical Center, CHA University School of MedicineDepartment of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of MedicineDepartment of Pediatrics, College of Medicine, The Catholic University of KoreaAsthma and Allergy Center, Department of Pediatrics, Inje University Sanggye Paik HospitalSCH Biomedical Informatics Research Unit, Soonchunhyang University Seoul HospitalAbstract Background Community–acquired pneumonia (CAP) is one of the leading worldwide causes of childhood morbidity and mortality. Its disease burden varies by age and etiology and is time dependent. We aimed to investigate the annual and seasonal patterns in etiologies of pediatric CAP requiring hospitalization. Methods We conducted a retrospective study in 30,994 children (aged 0–18 years) with CAP between 2010 and 2015 at 23 nationwide hospitals in South Korea. Mycoplasma pneumoniae (MP) pneumonia was clinically classified as macrolide-sensitive MP, macrolide-less effective MP (MLEP), and macrolide-refractory MP (MRMP) based on fever duration after initiation of macrolide treatment, regardless of the results of in vitro macrolide sensitivity tests. Results MP and respiratory syncytial virus (RSV) were the two most commonly identified pathogens of CAP. With the two epidemics of MP pneumonia (2011 and 2015), the rates of clinical MLEP and MRMP pneumonia showed increasing trends of 36.4% of the total MP pneumonia. In children < 2 years of age, RSV (34.0%) was the most common cause of CAP, followed by MP (9.4%); however, MP was the most common cause of CAP in children aged 2–18 years of age (45.3%). Systemic corticosteroid was most commonly administered for MP pneumonia. The rate of hospitalization in intensive care units was the highest for RSV pneumonia, and ventilator care was most commonly needed in cases of adenovirus pneumonia. Conclusions The present study provides fundamental data to establish public health policies to decrease the disease burden due to CAP and improve pediatric health.https://doi.org/10.1186/s12879-020-4810-9ChildrenPneumoniaRespiratory virusMycoplasma pneumoniaeMacrolide- refractoryMacrolide-sensitive |
| spellingShingle | Eun Lee Chul-Hong Kim Yong Ju Lee Hyo-Bin Kim Bong-Seong Kim Hyung Young Kim Yunsun Kim Sangyoung Kim Chorong Park Ju-Hee Seo In Suk Sol Myongsoon Sung Min Seob Song Dae Jin Song Young Min Ahn Hea Lin Oh Jinho Yu Sungsu Jung Kyung Suk Lee Ju Suk Lee Gwang Cheon Jang Yoon-Young Jang Eun Hee Chung Hai Lee Chung Sung-Min Choi Yun Jung Choi Man Yong Han Jung Yeon Shim Jin Tack Kim Chang-Keun Kim Hyeon-Jong Yang Pneumonia and Respiratory Disease Study Group of Korean Academy of Pediatric Allergy and Respiratory Disease Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea BMC Infectious Diseases Children Pneumonia Respiratory virus Mycoplasma pneumoniae Macrolide- refractory Macrolide-sensitive |
| title | Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea |
| title_full | Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea |
| title_fullStr | Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea |
| title_full_unstemmed | Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea |
| title_short | Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea |
| title_sort | annual and seasonal patterns in etiologies of pediatric community acquired pneumonia due to respiratory viruses and mycoplasma pneumoniae requiring hospitalization in south korea |
| topic | Children Pneumonia Respiratory virus Mycoplasma pneumoniae Macrolide- refractory Macrolide-sensitive |
| url | https://doi.org/10.1186/s12879-020-4810-9 |
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