Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns
Prolonged jaundice of newborns is a common pathology during the neonatal period. Recently, there has been a tendency toward an increased number of newborns with prolonged jaundice with duration longer than 14 days of life. According to the polyetiologic nature of neonatal jaundice, it is necessary t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2019-10-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2019/09/Mazur_5_19.pdf |
| _version_ | 1827614127528345600 |
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| author | O. H. Mazur O. S. Yablon O. S. Rubina M. M. Puhach A. P. Konoplitska |
| author_facet | O. H. Mazur O. S. Yablon O. S. Rubina M. M. Puhach A. P. Konoplitska |
| author_sort | O. H. Mazur |
| collection | DOAJ |
| description | Prolonged jaundice of newborns is a common pathology during the neonatal period. Recently, there has been a tendency toward an increased number of newborns with prolonged jaundice with duration longer than 14 days of life. According to the polyetiologic nature of neonatal jaundice, it is necessary to investigate new diagnostic signs that can predict the development of prolonged jaundice in newborns and, allow identification of new methods of differential diagnosis of neonatal jaundice, as well as decrease the frequency of this pathology. The parameters of serum alpha-fetoprotein (AFP) content in newborns with prolonged jaundice were studied. The content of AFP in blood serum was 1.7 times higher in newborns with prolonged jaundice than in newborns with jaundice for up to 14 days of life: Me = 671.1 [Q1 = 479.9; Q3 = 815.03] ng/ml and Me = 401.0 [Q1 = 284.9; Q3 = 684.0] ng/ml, respectively (P < 0.05). The content of blood serum AFP in newborns with prolonged jaundice was higher for total serum bilirubin greater than 250 μmole/l: Me = 626.2 [Q1 = 454.7; Q3 = 793.2] ng/ml which was confirmed by a strong direct correlation relationship (rxy = 0.64, P < 0.05). The results of the ROC analysis confirmed that AFP ≥ 571.7 ng/ml can identify newborns with prolonged jaundice with a sensitivity of 74.2% and a specificity of 74.5%. The area under the curve (AUC) was 0.870 (95% CI 0.804, 0.937), which confirms the good quality of the AFP model ≥ 571.7 ng/ml. |
| first_indexed | 2024-03-09T08:50:16Z |
| format | Article |
| id | doaj.art-be89aa0c4ece494db002065378b14f78 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-09T08:50:16Z |
| publishDate | 2019-10-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-be89aa0c4ece494db002065378b14f782023-12-02T14:35:55ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032019-10-01915636910.15407/ubj91.05.063Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newbornsO. H. Mazur0O. S. Yablon1O. S. Rubina2M. M. Puhach3A. P. Konoplitska4National Pirogov Memorial Medical University, Vinnytsia, UkraineNational Pirogov Memorial Medical University, Vinnytsia, UkraineNational Pirogov Memorial Medical University, Vinnytsia, UkraineNational Pirogov Memorial Medical University, Vinnytsia, UkraineNational Pirogov Memorial Medical University, Vinnytsia, UkraineProlonged jaundice of newborns is a common pathology during the neonatal period. Recently, there has been a tendency toward an increased number of newborns with prolonged jaundice with duration longer than 14 days of life. According to the polyetiologic nature of neonatal jaundice, it is necessary to investigate new diagnostic signs that can predict the development of prolonged jaundice in newborns and, allow identification of new methods of differential diagnosis of neonatal jaundice, as well as decrease the frequency of this pathology. The parameters of serum alpha-fetoprotein (AFP) content in newborns with prolonged jaundice were studied. The content of AFP in blood serum was 1.7 times higher in newborns with prolonged jaundice than in newborns with jaundice for up to 14 days of life: Me = 671.1 [Q1 = 479.9; Q3 = 815.03] ng/ml and Me = 401.0 [Q1 = 284.9; Q3 = 684.0] ng/ml, respectively (P < 0.05). The content of blood serum AFP in newborns with prolonged jaundice was higher for total serum bilirubin greater than 250 μmole/l: Me = 626.2 [Q1 = 454.7; Q3 = 793.2] ng/ml which was confirmed by a strong direct correlation relationship (rxy = 0.64, P < 0.05). The results of the ROC analysis confirmed that AFP ≥ 571.7 ng/ml can identify newborns with prolonged jaundice with a sensitivity of 74.2% and a specificity of 74.5%. The area under the curve (AUC) was 0.870 (95% CI 0.804, 0.937), which confirms the good quality of the AFP model ≥ 571.7 ng/ml.http://ukrbiochemjournal.org/wp-content/uploads/2019/09/Mazur_5_19.pdfalpha-fetoproteinbilirubinnewbornsprolonged jaundice |
| spellingShingle | O. H. Mazur O. S. Yablon O. S. Rubina M. M. Puhach A. P. Konoplitska Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns The Ukrainian Biochemical Journal alpha-fetoprotein bilirubin newborns prolonged jaundice |
| title | Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns |
| title_full | Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns |
| title_fullStr | Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns |
| title_full_unstemmed | Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns |
| title_short | Alpha-fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns |
| title_sort | alpha fetoprotein as a biochemical diagnostic and prognostic marker for prolonged jaundice in newborns |
| topic | alpha-fetoprotein bilirubin newborns prolonged jaundice |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2019/09/Mazur_5_19.pdf |
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