Dendritic cell derived cytokines in human natural killer cell differentiation and activation
Dendritic cells (DCs) and natural killer (NK) cells shape each other’s functions early during immune responses. DCs activate NK cells and NK cells can mature or kill DCs. In this review we will discuss which DC and NK cell subsets are mainly affected by this interaction, where these encounters might...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00365/full |
| _version_ | 1818137291065917440 |
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| author | Obinna eChijioke Christian eMuenz |
| author_facet | Obinna eChijioke Christian eMuenz |
| author_sort | Obinna eChijioke |
| collection | DOAJ |
| description | Dendritic cells (DCs) and natural killer (NK) cells shape each other’s functions early during immune responses. DCs activate NK cells and NK cells can mature or kill DCs. In this review we will discuss which DC and NK cell subsets are mainly affected by this interaction, where these encounters might take place and which signals are exchanged. Finally, we will point out what the clinical benefit of understanding this interaction might be and how it changed our view on NK cells as innate lymphocytes. |
| first_indexed | 2024-12-11T09:53:58Z |
| format | Article |
| id | doaj.art-be8a33a544584988a72903a4826885b0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T09:53:58Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-be8a33a544584988a72903a4826885b02022-12-22T01:12:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-11-01410.3389/fimmu.2013.0036570100Dendritic cell derived cytokines in human natural killer cell differentiation and activationObinna eChijioke0Christian eMuenz1University of ZurichUniversity of ZurichDendritic cells (DCs) and natural killer (NK) cells shape each other’s functions early during immune responses. DCs activate NK cells and NK cells can mature or kill DCs. In this review we will discuss which DC and NK cell subsets are mainly affected by this interaction, where these encounters might take place and which signals are exchanged. Finally, we will point out what the clinical benefit of understanding this interaction might be and how it changed our view on NK cells as innate lymphocytes.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00365/fullil-12Immunological SynapseIL-15IL-18DNAM-1IFN-alpha |
| spellingShingle | Obinna eChijioke Christian eMuenz Dendritic cell derived cytokines in human natural killer cell differentiation and activation Frontiers in Immunology il-12 Immunological Synapse IL-15 IL-18 DNAM-1 IFN-alpha |
| title | Dendritic cell derived cytokines in human natural killer cell differentiation and activation |
| title_full | Dendritic cell derived cytokines in human natural killer cell differentiation and activation |
| title_fullStr | Dendritic cell derived cytokines in human natural killer cell differentiation and activation |
| title_full_unstemmed | Dendritic cell derived cytokines in human natural killer cell differentiation and activation |
| title_short | Dendritic cell derived cytokines in human natural killer cell differentiation and activation |
| title_sort | dendritic cell derived cytokines in human natural killer cell differentiation and activation |
| topic | il-12 Immunological Synapse IL-15 IL-18 DNAM-1 IFN-alpha |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00365/full |
| work_keys_str_mv | AT obinnaechijioke dendriticcellderivedcytokinesinhumannaturalkillercelldifferentiationandactivation AT christianemuenz dendriticcellderivedcytokinesinhumannaturalkillercelldifferentiationandactivation |