Gastric mucosal damage due to partial sleep deprivation in rats
Abstract Background: Nowadays, working long hours and shift work are inevitable, even though these working schedules are associated with several physical and mental effects. Gastrointestinal complaints are common among their physical effects. Recent studies have shown organoprotective effect of mela...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Science
2011-10-01
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| Series: | طب کار |
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| Online Access: | http://tkj.ssu.ac.ir/article-1-40-en.html |
| _version_ | 1818671438507278336 |
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| author | KH Sadeghniiat Haghighi E Noori GH Hassanzadeh AR Dehpour |
| author_facet | KH Sadeghniiat Haghighi E Noori GH Hassanzadeh AR Dehpour |
| author_sort | KH Sadeghniiat Haghighi |
| collection | DOAJ |
| description | Abstract
Background: Nowadays, working long hours and shift work are inevitable, even though these working schedules are associated with several physical and mental effects. Gastrointestinal complaints are common among their physical effects. Recent studies have shown organoprotective effect of melatonin in gastrointestinal tract. In this study we investigated gastric mucosal damage due to partial sleep deprivation and the possible role of melatonin in this damage.
Methods: 24 male rats were assigned in two groups: 12 rats in control group with normal sleep and 12 rats in partial sleep deprivation group. For partial sleep deprivation, we used a slowly rotating cylindrical cage, which was rotating 23 hours a day for 14 days. Animals were food deprived in the last 24 hours of study. Finally, their stomachs were assessed grossly and histologically. We also performed ELISA assay for measurement of their serum melatonin.
Results: Mucosal damage was seen to some extent in both groups. Damage severity was significantly higher in partial sleep deprivation group (P<0.001). In addition, serum melatonin was significantly lower in partial sleep deprivation group (P<0.001).
Conclusion: We conclude that partial sleep deprivation could induce gastric mucosal damage in rats. Even though serum melatonin was lower in partial sleep deprived rats. So we could propose that decreased serum melatonin might have a role in this damage. |
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| format | Article |
| id | doaj.art-be8a634826e64edaa56f18217c552e1a |
| institution | Directory Open Access Journal |
| issn | 2251-7189 2251-8274 |
| language | English |
| last_indexed | 2024-12-17T07:24:00Z |
| publishDate | 2011-10-01 |
| publisher | Shahid Sadoughi University of Medical Science |
| record_format | Article |
| series | طب کار |
| spelling | doaj.art-be8a634826e64edaa56f18217c552e1a2022-12-21T21:58:41ZengShahid Sadoughi University of Medical Scienceطب کار2251-71892251-82742011-10-01321115Gastric mucosal damage due to partial sleep deprivation in ratsKH Sadeghniiat Haghighi0E Noori1GH Hassanzadeh2AR Dehpour3 Tehran University of Medical Sciences Tehran University of Medical Sciences Tehran University of Medical Sciences Tehran University of Medical Sciences Abstract Background: Nowadays, working long hours and shift work are inevitable, even though these working schedules are associated with several physical and mental effects. Gastrointestinal complaints are common among their physical effects. Recent studies have shown organoprotective effect of melatonin in gastrointestinal tract. In this study we investigated gastric mucosal damage due to partial sleep deprivation and the possible role of melatonin in this damage. Methods: 24 male rats were assigned in two groups: 12 rats in control group with normal sleep and 12 rats in partial sleep deprivation group. For partial sleep deprivation, we used a slowly rotating cylindrical cage, which was rotating 23 hours a day for 14 days. Animals were food deprived in the last 24 hours of study. Finally, their stomachs were assessed grossly and histologically. We also performed ELISA assay for measurement of their serum melatonin. Results: Mucosal damage was seen to some extent in both groups. Damage severity was significantly higher in partial sleep deprivation group (P<0.001). In addition, serum melatonin was significantly lower in partial sleep deprivation group (P<0.001). Conclusion: We conclude that partial sleep deprivation could induce gastric mucosal damage in rats. Even though serum melatonin was lower in partial sleep deprived rats. So we could propose that decreased serum melatonin might have a role in this damage.http://tkj.ssu.ac.ir/article-1-40-en.htmlgasteric mucosal damagepartial sleep deprivationserum melatonin |
| spellingShingle | KH Sadeghniiat Haghighi E Noori GH Hassanzadeh AR Dehpour Gastric mucosal damage due to partial sleep deprivation in rats طب کار gasteric mucosal damage partial sleep deprivation serum melatonin |
| title | Gastric mucosal damage due to partial sleep deprivation in rats |
| title_full | Gastric mucosal damage due to partial sleep deprivation in rats |
| title_fullStr | Gastric mucosal damage due to partial sleep deprivation in rats |
| title_full_unstemmed | Gastric mucosal damage due to partial sleep deprivation in rats |
| title_short | Gastric mucosal damage due to partial sleep deprivation in rats |
| title_sort | gastric mucosal damage due to partial sleep deprivation in rats |
| topic | gasteric mucosal damage partial sleep deprivation serum melatonin |
| url | http://tkj.ssu.ac.ir/article-1-40-en.html |
| work_keys_str_mv | AT khsadeghniiathaghighi gastricmucosaldamageduetopartialsleepdeprivationinrats AT enoori gastricmucosaldamageduetopartialsleepdeprivationinrats AT ghhassanzadeh gastricmucosaldamageduetopartialsleepdeprivationinrats AT ardehpour gastricmucosaldamageduetopartialsleepdeprivationinrats |