Cardiotoxicity and Chemotherapy—The Role of Precision Medicine
Cancer and cardiovascular disease are the leading causes of death in the United Kingdom. Many systemic anticancer treatments are associated with short- and long-term cardiotoxicity. With improving cancer survival and an ageing population, identifying those patients at the greatest risk of cardiotoxi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Diseases |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9721/9/4/90 |
| _version_ | 1827673033492398080 |
|---|---|
| author | Thyla Viswanathan Chim C. Lang Russell D. Petty Mark A. Baxter |
| author_facet | Thyla Viswanathan Chim C. Lang Russell D. Petty Mark A. Baxter |
| author_sort | Thyla Viswanathan |
| collection | DOAJ |
| description | Cancer and cardiovascular disease are the leading causes of death in the United Kingdom. Many systemic anticancer treatments are associated with short- and long-term cardiotoxicity. With improving cancer survival and an ageing population, identifying those patients at the greatest risk of cardiotoxicity from their cancer treatment is becoming a research priority and has led to a new subspecialty: cardio-oncology. In this concise review article, we discuss cardiotoxicity and systemic anticancer therapy, with a focus on chemotherapy. We also discuss the challenge of identifying those at risk and the role of precision medicine as we strive for a personalised approach to this clinical scenario. |
| first_indexed | 2024-03-10T04:18:18Z |
| format | Article |
| id | doaj.art-be8b22564da14d5a9ea3395e749e64e4 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-10T04:18:18Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-be8b22564da14d5a9ea3395e749e64e42023-11-23T07:56:00ZengMDPI AGDiseases2079-97212021-12-01949010.3390/diseases9040090Cardiotoxicity and Chemotherapy—The Role of Precision MedicineThyla Viswanathan0Chim C. Lang1Russell D. Petty2Mark A. Baxter3Dundee School of Medicine, Ninewells Hospital, University of Dundee, Dundee DD2 1SY, UKDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD2 1SY, UKDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD2 1SY, UKDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD2 1SY, UKCancer and cardiovascular disease are the leading causes of death in the United Kingdom. Many systemic anticancer treatments are associated with short- and long-term cardiotoxicity. With improving cancer survival and an ageing population, identifying those patients at the greatest risk of cardiotoxicity from their cancer treatment is becoming a research priority and has led to a new subspecialty: cardio-oncology. In this concise review article, we discuss cardiotoxicity and systemic anticancer therapy, with a focus on chemotherapy. We also discuss the challenge of identifying those at risk and the role of precision medicine as we strive for a personalised approach to this clinical scenario.https://www.mdpi.com/2079-9721/9/4/90cardiotoxicitycardio-oncologyheart failurecancer therapyprecision medicinepharmacogenetics |
| spellingShingle | Thyla Viswanathan Chim C. Lang Russell D. Petty Mark A. Baxter Cardiotoxicity and Chemotherapy—The Role of Precision Medicine Diseases cardiotoxicity cardio-oncology heart failure cancer therapy precision medicine pharmacogenetics |
| title | Cardiotoxicity and Chemotherapy—The Role of Precision Medicine |
| title_full | Cardiotoxicity and Chemotherapy—The Role of Precision Medicine |
| title_fullStr | Cardiotoxicity and Chemotherapy—The Role of Precision Medicine |
| title_full_unstemmed | Cardiotoxicity and Chemotherapy—The Role of Precision Medicine |
| title_short | Cardiotoxicity and Chemotherapy—The Role of Precision Medicine |
| title_sort | cardiotoxicity and chemotherapy the role of precision medicine |
| topic | cardiotoxicity cardio-oncology heart failure cancer therapy precision medicine pharmacogenetics |
| url | https://www.mdpi.com/2079-9721/9/4/90 |
| work_keys_str_mv | AT thylaviswanathan cardiotoxicityandchemotherapytheroleofprecisionmedicine AT chimclang cardiotoxicityandchemotherapytheroleofprecisionmedicine AT russelldpetty cardiotoxicityandchemotherapytheroleofprecisionmedicine AT markabaxter cardiotoxicityandchemotherapytheroleofprecisionmedicine |