Methods for monitoring cancer cell pyroptosis
Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response. The relationship between pyroptosis and cance...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2022-04-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | https://www.cancerbiomed.org/content/19/4/398 |
| _version_ | 1818218869964144640 |
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| author | Shuo Wang Yuantong Liu Lu Zhang Zhijun Sun |
| author_facet | Shuo Wang Yuantong Liu Lu Zhang Zhijun Sun |
| author_sort | Shuo Wang |
| collection | DOAJ |
| description | Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response. The relationship between pyroptosis and cancer has become a popular topic in immunological research. Multiple strategies for inducing pyroptosis in cancer cells have been developed for cancer therapy, including chemotherapy, small molecule drugs, and nanomedicines. In this review, we systematically discuss recent advances in research on the mechanisms of pyroptosis, and compare pyroptosis with apoptosis and necroptosis from several aspects. The development of various experimental systems has accompanied rapid progress in this field, but little consensus on monitoring pyroptosis is currently available. We focus on techniques commonly used to monitor pyroptosis, and describe future techniques that may be used to increase our knowledge in this field. Overall, the advancement of pyroptosis detection methods will help researchers to better investigate the relationships between pyroptosis and various cancers, and should provide insights into the use of these promising tools for cancer treatments. |
| first_indexed | 2024-12-12T07:30:37Z |
| format | Article |
| id | doaj.art-be8d7156ebbf4dc9a46bf18aa275254c |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-12-12T07:30:37Z |
| publishDate | 2022-04-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-be8d7156ebbf4dc9a46bf18aa275254c2022-12-22T00:33:02ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412022-04-0119439841410.20892/j.issn.2095-3941.2021.0504Methods for monitoring cancer cell pyroptosisShuo Wang0Yuantong Liu1Lu Zhang2Zhijun Sun3The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaPyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response. The relationship between pyroptosis and cancer has become a popular topic in immunological research. Multiple strategies for inducing pyroptosis in cancer cells have been developed for cancer therapy, including chemotherapy, small molecule drugs, and nanomedicines. In this review, we systematically discuss recent advances in research on the mechanisms of pyroptosis, and compare pyroptosis with apoptosis and necroptosis from several aspects. The development of various experimental systems has accompanied rapid progress in this field, but little consensus on monitoring pyroptosis is currently available. We focus on techniques commonly used to monitor pyroptosis, and describe future techniques that may be used to increase our knowledge in this field. Overall, the advancement of pyroptosis detection methods will help researchers to better investigate the relationships between pyroptosis and various cancers, and should provide insights into the use of these promising tools for cancer treatments.https://www.cancerbiomed.org/content/19/4/398pyroptosisgasdermincaspasecancer immunotherapycell death |
| spellingShingle | Shuo Wang Yuantong Liu Lu Zhang Zhijun Sun Methods for monitoring cancer cell pyroptosis Cancer Biology & Medicine pyroptosis gasdermin caspase cancer immunotherapy cell death |
| title | Methods for monitoring cancer cell pyroptosis |
| title_full | Methods for monitoring cancer cell pyroptosis |
| title_fullStr | Methods for monitoring cancer cell pyroptosis |
| title_full_unstemmed | Methods for monitoring cancer cell pyroptosis |
| title_short | Methods for monitoring cancer cell pyroptosis |
| title_sort | methods for monitoring cancer cell pyroptosis |
| topic | pyroptosis gasdermin caspase cancer immunotherapy cell death |
| url | https://www.cancerbiomed.org/content/19/4/398 |
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