Synthesis and Antitumor Activity of New Thiazole Nortopsentin Analogs

Synthesis and Antitumor Activity of New Thiazole Nortopsentin Analogs

New thiazole nortopsentin analogs in which one of the two indole units was replaced by a naphthyl and/or 7-azaindolyl portion, were conveniently synthesized. Among these, three derivatives showed good antiproliferative activity, in particular against MCF7 cell line, with GI50 values in the micromola...

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Bibliographic Details
Main Authors: Virginia Spanò, Alessandro Attanzio, Stella Cascioferro, Anna Carbone, Alessandra Montalbano, Paola Barraja, Luisa Tesoriere, Girolamo Cirrincione, Patrizia Diana, Barbara Parrino
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Marine Drugs
Subjects:
marine alkaloids
bis-indolyl alkaloids
thiazolyl-indoles
apoptosis
antiproliferative activity
Online Access:http://www.mdpi.com/1660-3397/14/12/226

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