H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China
Abstract Background Chronic total coronary occlusion (CTO) is serious and the "last bastion" of percutaneous coronary intervention. Hypertension and hyperhomocysteinemia (HHCY) are synergistic and significantly increase cardiovascular event risk. The relationship between H-type hypertensio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03345-1 |
| _version_ | 1797801596993667072 |
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| author | Kaiyong Xiao Zhe Xv Yuling Xv Jianping Wang Lian Xiao Zhou Kang Jianhui Zhu Zhongwei He Guan Huang |
| author_facet | Kaiyong Xiao Zhe Xv Yuling Xv Jianping Wang Lian Xiao Zhou Kang Jianhui Zhu Zhongwei He Guan Huang |
| author_sort | Kaiyong Xiao |
| collection | DOAJ |
| description | Abstract Background Chronic total coronary occlusion (CTO) is serious and the "last bastion" of percutaneous coronary intervention. Hypertension and hyperhomocysteinemia (HHCY) are synergistic and significantly increase cardiovascular event risk. The relationship between H-type hypertension and CTO remains unclear; thus, this cross-sectional study investigated this potential association. Methods Between January 2018 and June 2022, 1446 individuals from southwest China were recruited to participate in this study. CTO was defined as complete coronary artery occlusion persisting for over three months. H-type hypertension was defined as hypertension with plasma homocysteine levels ≥ 15 µmol/L. Multivariate logistic regression models were applied to assess the association between H-type hypertension and CTO. Receiver operating characteristic (ROC) curves were generated to determine the accuracy of H-type hypertension in predicting CTO. Results Of the 1446 individuals, 397 had CTO, and 545 had H-type hypertension. After multivariate adjustment, the odds ratio (OR) for CTO in individuals with H-type hypertension was 2.3-fold higher (95% CI 1.01–5.26) than that in healthy controls. The risk of CTO is higher in individuals with H-type hypertension than in those with isolated HHCY and hypertension. The area under the ROC curve for CTO was 0.685 (95% CI, 0.653–0.717) for H-type hypertension. Conclusions In southwest China, H-type hypertension is significantly related to the occurrence of CTO. Trial registration This retrospective study was registered with the Chinese Clinical Trials Registry ( http://www.chictr.org.cn , ChiCTR2100050519.2.2). |
| first_indexed | 2024-03-13T04:53:01Z |
| format | Article |
| id | doaj.art-be9044ad6a59486085966254a66ea4e5 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-13T04:53:01Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-be9044ad6a59486085966254a66ea4e52023-06-18T11:06:07ZengBMCBMC Cardiovascular Disorders1471-22612023-06-012311910.1186/s12872-023-03345-1H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest ChinaKaiyong Xiao0Zhe Xv1Yuling Xv2Jianping Wang3Lian Xiao4Zhou Kang5Jianhui Zhu6Zhongwei He7Guan Huang8Department of Cardiology, Guangyuan Central HospitalDepartment of Pediatric Medicine, Guangyuan Central HospitalSterilization Supply Center, Guangyuan Central HospitalDepartment of Cardiology, Guangyuan Central HospitalDepartment of Cardiology, Guangyuan Central HospitalDepartment of Medical Statistics, Guangyuan Central HospitalDepartment of Cardiology, Guangyuan Central HospitalDepartment of Cardiology, Guangyuan Central HospitalMedical Laboratory Center, Guangyuan Central HospitalAbstract Background Chronic total coronary occlusion (CTO) is serious and the "last bastion" of percutaneous coronary intervention. Hypertension and hyperhomocysteinemia (HHCY) are synergistic and significantly increase cardiovascular event risk. The relationship between H-type hypertension and CTO remains unclear; thus, this cross-sectional study investigated this potential association. Methods Between January 2018 and June 2022, 1446 individuals from southwest China were recruited to participate in this study. CTO was defined as complete coronary artery occlusion persisting for over three months. H-type hypertension was defined as hypertension with plasma homocysteine levels ≥ 15 µmol/L. Multivariate logistic regression models were applied to assess the association between H-type hypertension and CTO. Receiver operating characteristic (ROC) curves were generated to determine the accuracy of H-type hypertension in predicting CTO. Results Of the 1446 individuals, 397 had CTO, and 545 had H-type hypertension. After multivariate adjustment, the odds ratio (OR) for CTO in individuals with H-type hypertension was 2.3-fold higher (95% CI 1.01–5.26) than that in healthy controls. The risk of CTO is higher in individuals with H-type hypertension than in those with isolated HHCY and hypertension. The area under the ROC curve for CTO was 0.685 (95% CI, 0.653–0.717) for H-type hypertension. Conclusions In southwest China, H-type hypertension is significantly related to the occurrence of CTO. Trial registration This retrospective study was registered with the Chinese Clinical Trials Registry ( http://www.chictr.org.cn , ChiCTR2100050519.2.2).https://doi.org/10.1186/s12872-023-03345-1H-type hypertensionChronic total coronary occlusionCoronary occlusionCoronary artery diseaseHomocysteineHyperhomocysteinemia |
| spellingShingle | Kaiyong Xiao Zhe Xv Yuling Xv Jianping Wang Lian Xiao Zhou Kang Jianhui Zhu Zhongwei He Guan Huang H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China BMC Cardiovascular Disorders H-type hypertension Chronic total coronary occlusion Coronary occlusion Coronary artery disease Homocysteine Hyperhomocysteinemia |
| title | H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China |
| title_full | H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China |
| title_fullStr | H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China |
| title_full_unstemmed | H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China |
| title_short | H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from southwest China |
| title_sort | h type hypertension is a risk factor for chronic total coronary artery occlusion a cross sectional study from southwest china |
| topic | H-type hypertension Chronic total coronary occlusion Coronary occlusion Coronary artery disease Homocysteine Hyperhomocysteinemia |
| url | https://doi.org/10.1186/s12872-023-03345-1 |
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