Anticancerous Effects of Polygonum Avicular Exert through Fas Ligand and Bcl2
Background: Herbal medicine is a new complementary strategy for treating diseases such as cancer. However, its mechanism of action is not clear yet. This study investigates antitumor efficacy of Polygonum avicular extract on MCF-7 cell line. Methods: MCF-7 cells were treated with different concentr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2013-12-01
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| Series: | Basic & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/38 |
| Summary: | Background: Herbal medicine is a new complementary strategy for treating diseases such as cancer. However, its mechanism of action is not clear yet. This study investigates antitumor efficacy of Polygonum avicular extract on MCF-7 cell line.
Methods: MCF-7 cells were treated with different concentrations of (50, 100, 150, 200, 250, 300,350 400 ng/µl) Polygonum avicular at different time intervals (6, 12, 24, and 48 hrs). In order to evaluate the expression level of FasL and Bcl2 genes, RT-PCR technique was employed.
Results: The obtained results demonstrate that expression of FasL gene was increased in Polygonum avicular treated cells in comparison to control group. Down-regulation of Bcl2 expression was observed during the treatment.
Conclusion: Polygonum aviculare herbal extract may induce apoptosis through up-regulation of FasL and down-regulation of Bcl2 gene, however, its complete mechanism of action must be elucidated. |
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| ISSN: | 2228-6527 2228-5466 |